Xenon-Enhanced Dynamic Dual-Energy CT Is Able to Quantify Sinus Ventilation Using Laminar and Pulsating Air-/Gas Flow Before and After Surgery: A Pilot Study in a Cadaver Model [0.03%]
动态双重能量CT能量化鼻窦通气：术前和术后尸体模型中层流和脉动空气/气体流动的定量研究
Sven Becker,Tilman Huppertz,Winfried Möller et al.
Sven Becker et al.
Background: Chronic rhinosinusitis is a common disease with a significant impact on the quality of life. Topical drug delivery to the paranasal sinuses is not efficient to prevent sinus surgery or expensive biologic treat...
Still SDAPing Along: 20 Years of the Structural Database of Allergenic Proteins [0.03%]
结结地前行——结构过敏蛋白数据库(SDAP)二十周年回顾
Catherine H Schein,Surendra S Negi,Werner Braun
Catherine H Schein
The introduction of plant extracts to mitigate the symptoms of "hay fever", about a century ago, led to discoveries beginning sixty years ago on determining the sequences and eventually structures of allergenic proteins. As more proteins we...
Impact of Therapeutics on Unified Immunity During Allergic Asthma and Respiratory Infections [0.03%]
过敏性哮喘和呼吸道感染期间治疗对统一免疫力的影响
Armando S Flores-Torres,Amali E Samarasinghe
Armando S Flores-Torres
Asthma is a common chronic respiratory disease that affects millions of people worldwide. Patients with allergic asthma, the most prevalent asthma endotype, are widely considered to possess a defective immune response against some respirato...
Basophil Activation to Gluten and Non-Gluten Proteins in Wheat-Dependent Exercise-Induced Anaphylaxis [0.03%]
小麦依赖性运动诱发过敏反应中肥大细胞活化与麸质及非麸质蛋白质的关系
Angelika Miriam Gabler,Julia Gebhard,Marie-Christin Norwig et al.
Angelika Miriam Gabler et al.
Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a cofactor-induced wheat allergy. Gluten proteins, especially ω5-gliadins, are known as major allergens, but partially hydrolyzed wheat proteins (HWPs) also play a role. Our study inv...
Studies on Clinical Features, Mechanisms, and Management of Olfactory Dysfunction Secondary to Chronic Rhinosinusitis [0.03%]
慢性鼻窦炎继发嗅觉障碍的临床特征、机制和治疗研究进展
Yi-Tsen Lin,Te-Huei Yeh
Yi-Tsen Lin
Chronic rhinosinusitis (CRS) is one of the most common causes of inflammation of the olfactory system, warranting investigation of the link between chronic inflammation and the loss of olfactory function. Type 2 inflammation is closely rela...
Intralymphatic Immunotherapy (ILIT) With Bee Venom Allergens: A Clinical Proof-of-Concept Study and the Very First ILIT in Humans [0.03%]
蜜蜂毒液过敏原的淋巴内免疫治疗（ILIT）：概念验证性研究及人类首次ILIT试验
Alexandra Chabot,Gabriela Senti,Iris Erdmann et al.
Alexandra Chabot et al.
Background: Subcutaneous venom immunotherapy (VIT) represents an effective treatment against bee venom allergy. However, it involves long treatment times, high costs, and the risk of adverse events (AEs). Shorter, safer, ...
The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions [0.03%]
药物反应T细胞的活化模式对超敏反应临床表现的影响
Natascha Wuillemin,Barbara Ballmer-Weber,Christoph Schlapbach et al.
Natascha Wuillemin et al.
Rationale: β-lactam antibiotics cause drug hypersensitivity reactions (DHR) with various clinical pictures from minor affections like maculopapular exanthema (MPE) and urticaria to severe cutaneous adverse reactions and ...
Successful Desensitization to mRNA COVID-19 Vaccine in a Case Series of Patients With a History of Anaphylaxis to the First Vaccine Dose [0.03%]
过敏反应病史患者接种新冠疫苗后成功脱敏的病例报告系列研究
Faisal AlMuhizi,Shaonie Ton-Leclerc,Michael Fein et al.
Faisal AlMuhizi et al.
Background: Coronavirus disease 2109 (COVID-19) vaccines have recently been approved to curb the global pandemic. The risk of allergic reactions to the vaccine polyethylene glycol (PEG) component has raised significant pu...
Immune Metabolism-An Opportunity to Better Understand Allergic Pathology and Improve Treatment of Allergic Diseases? [0.03%]
免疫代谢——更好的理解过敏病理及改善过敏性疾病治疗的机会？
Alexandra Goretzki,Jennifer Zimmermann,Yen-Ju Lin et al.
Alexandra Goretzki et al.
Masked Delivery of Allergen in Nanoparticles Safely Attenuates Anaphylactic Response in Murine Models of Peanut Allergy [0.03%]
纳米颗粒递送的过敏原可安全缓解小鼠花生过敏模型中的过敏性反应
Kevin R Hughes,Michael N Saunders,Jeffrey J Landers et al.
Kevin R Hughes et al.
Food allergy is a growing health concern worldwide. Current allergen-specific immunotherapy (AIT) approaches require frequent dosing over extended periods of time and may induce anaphylaxis due to allergen-effector cell interactions. A crit...