Risk Assessment in Drug Hypersensitivity: Detecting Small Molecules Which Outsmart the Immune System [0.03%]
药物过敏风险评估：检测可躲避免疫系统的微小分子
Werner J Pichler,Stephen Watkins,Daniel Yerly
Werner J Pichler
Drug hypersensitivity (DH) reactions are clinically unusual because the underlying immune stimulations are not antigen-driven, but due to non-covalent drug-protein binding. The drugs may bind to immune receptors like HLA or TCR which elicit...
Role of Th17 Cytokines in Airway Remodeling in Asthma and Therapy Perspectives [0.03%]
哮喘气道重构中Th17细胞因子的作用及治疗前景展望
Victor Margelidon-Cozzolino,Anne Tsicopoulos,Cécile Chenivesse et al.
Victor Margelidon-Cozzolino et al.
Airway remodeling is a frequent pathological feature of severe asthma leading to permanent airway obstruction in up to 50% of cases and to respiratory disability. Although structural changes related to airway remodeling are well-characteriz...
Picomolar Sensitivity Analysis of Multiple Bradykinin-Related Peptides in the Blood Plasma of Patients With Hereditary Angioedema in Remission: A Pilot Study [0.03%]
针对遗传性血管水肿缓解期患者血浆多种缓激肽相关肽皮摩尔敏感性分析的初步研究
François Marceau,Georges-Etienne Rivard,Jacques Hébert et al.
François Marceau et al.
Background: Hereditary angioedema (HAE) is a rare autosomal dominant disease; the most well understood forms concern the haplodeficiency of C1 esterase inhibitor (C1INH) and a gain of function mutation of factor XII (FXII...
Analysis of Breakthrough Reactions in 1,143 Desensitization Procedures in a Single Tertiary Hospital Using a One-Bag Desensitization Protocol [0.03%]
单中心使用一次性袋式脱敏方案进行1143例脱敏治疗的突破反应分析
Hyun Hwa Kim,Jeongmin Seo,Yoon Hae Ahn et al.
Hyun Hwa Kim et al.
Background: Drug desensitization is helpful for patients who have experienced significant hypersensitivity reactions (HSRs) to antineoplastic agents. One-bag desensitization protocols, attracting attention in recent years...
Plant Stress Scenarios Differentially Affect Expression and IgE Reactivity of Grass Group-1 Allergen (β-Expansin) in Maize and Rice Pollen [0.03%]
植物胁迫对玉米和水稻花粉中的草类1号过敏原(β-扩张素)的表达及其IgE反应性的影响不同
Yotin Juprasong,Wisuwat Songnuan
Yotin Juprasong
Grass pollen is among the most common outdoor aeroallergens eliciting pollen allergies throughout the world. Grass group-1 allergen or β-expansin is recognized as a major pollen allergen, particularly in the grass family Poaceae. Expressio...
Ofilia Mvoundza Ndjindji,Joel Fleury Djoba Siawaya
Ofilia Mvoundza Ndjindji
The consensus is that allergic diseases are increasing in Africa. However, this paradigm shift has not yet been translated into practice. Focused on infectious diseases (malaria, tuberculosis, HIV), health policies in Sub-Saharan Africa hav...
Immunoglobulin E-Dependent Activation of Immune Cells in Rhinovirus-Induced Asthma Exacerbation [0.03%]
免疫球蛋白E依赖性免疫细胞活化在呼吸道病毒诱导的哮喘恶化中的作用
Toshiaki Kawakami,Kazumi Kasakura,Yu Kawakami et al.
Toshiaki Kawakami et al.
Acute exacerbation is the major cause of asthma morbidity, mortality, and health-care costs. Respiratory viral infections, particularly rhinovirus (RV) infections, are associated with the majority of asthma exacerbations. The risk for bronc...
An Evaluation of the Mechanisms of Galacto-Oligosaccharide (GOS)-Induced IgE Cross-Linking on Basophils in GOS Allergy [0.03%]
低聚半乳糖过敏 basophil 交叉致敏的机理研究
Li Yuan Gabriella Nadine Lee,Si Yuan Leow,Hongmei Wen et al.
Li Yuan Gabriella Nadine Lee et al.
The prebiotics, galacto-oligosaccharides (GOS), are small carbohydrate molecules with 1-7 galactose units linked to glucose and have been shown to trigger IgE-mediated anaphylaxis in some cases following ingestion. It is still an unresolved...
Andrea Wangorsch,Stephan Scheurer,Miguel Blanca et al.
Andrea Wangorsch et al.
Only a small fraction of proteins in plants and animals are classified as allergens. The allergenic properties are frequently attributed to certain functional characteristics of the proteins, such as a role in the plant defense against biot...
Implementation of MALDI-TOF Mass Spectrometry to Identify Fungi From the Indoor Environment as an Added Value to the Classical Morphology-Based Identification Tool [0.03%]
用于鉴定室内环境真菌的基质辅助激光解吸电离飞行时间质谱技术作为传统形态学鉴定工具的补充价值研究
Natacha Motteu,Berdieke Goemaere,Sandrine Bladt et al.
Natacha Motteu et al.
Introduction: During the last decades, molds in the indoor environment have raised concern regarding their potential adverse health effects. The genera Aspergillus, Cladosporium, Penicillium, Alternaria, and yeasts, the m...