G Protein-Coupled Receptor Kinase 2 (GRK2) Regulates T Cell Response in a Murine Model of House Dust Mite-Induced Asthma [0.03%]
G蛋白偶联受体激酶2通过调节T细胞反应影响尘螨诱导的小鼠哮喘模型中的气道炎症和高反应性
Ananth K Kammala,Canchai Yang,Reynold A Panettieri et al.
Ananth K Kammala et al.
G protein-coupled receptor kinase 2 (GRK2) is an adapter protein that modulates G protein-coupled receptor (GPCR) signaling. It also regulates the functions and activity of other intracellular proteins in many cell types. Accordingly, GRK2 ...
Almudena Testera-Montes,Raquel Jurado,Maria Salas et al.
Almudena Testera-Montes et al.
Allergic mechanisms account for most cases of chronic rhinitis. This condition is associated with significant impairment of quality of life and high indirect costs. The identification of the allergic triggers of rhinitis has been historical...
Patient-Reported Control of Asthma, Nasal Polyposis, and Middle-Ear Symptoms in NSAID-Exacerbated Respiratory Disease [0.03%]
鼻用糖皮质激素致敏性呼吸系统疾病患者的哮喘、鼻息肉和中耳症状控制状况
Anna Suikkila,Lena Hafrén,Annina Lyly et al.
Anna Suikkila et al.
Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is an adult-onset inflammatory condition of the upper and lower airways. It is characterized by the co-existence of asthma, nasal polyposis, and hypersensit...
Dropouts From Sublingual Immunotherapy and the Transition to Subcutaneous Immunotherapy in House Dust Mite-Sensitized Allergic Rhinitis Patients [0.03%]
舌下免疫治疗脱落的尘螨过敏性鼻炎患者的皮下免疫治疗转换疗法
Huan Chen,Guo-Qing Gong,Mei Ding et al.
Huan Chen et al.
Purpose: Both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) are effective in reducing symptoms and medication scores and inducing long-term efficacy in patients with allergic rhinitis (AR). However, SLIT has been ass...
Biologic Responses to House Dust Mite Exposure in the Environmental Exposure Unit [0.03%]
环境暴露控制下的尘螨吸入对人体内的生物反应的影响研究
Lubnaa Hossenbaccus,Sophia Linton,Jenny Thiele et al.
Lubnaa Hossenbaccus et al.
Introduction: Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa that can be modeled using Controlled Allergen Exposure Facilities (CACF). Recently, we clinically validated the house dust mite (HDM) Environmental Exposure...
Characterization of Innate Immune Responses to House Dust Mite Allergens: Pitfalls and Limitations [0.03%]
家用尘螨过敏原诱导先天性免疫反应的研究：困难与局限性
Alain Jacquet
Alain Jacquet
Whereas house dust mite (HDM) allergy results from a dysregulated Th2-biased adaptive immune response, activation of innate immune signaling pathways is a critical prerequisite for the initiation of HDM sensitizations. Such innate sensing i...
Elizabeth Maria Mercer Mourao,Nelson Augusto Rosario
Elizabeth Maria Mercer Mourao
Background: Conjunctival provocation test (CPT) is used to demonstrate clinical relevance to a specific allergen. Blomia tropicalis (Bt) is a prevalent allergen in tropical regions. Its major allergen Blo t 5 is commonly detected in house d...
Julien Lambert
Julien Lambert
Contact dermatitis is a continuous growing environmental and occupational health problem. It results in high costs for health care systems and the economy due to productivity loss. Moreover, it has a huge impact on the quality of life of pa...
Araceli Díaz-Perales,Maria M Escribese,María Garrido-Arandia et al.
Araceli Díaz-Perales et al.
Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molec...
Potent Anti-Inflammatory Effects of Tetracyclines on Human Eosinophils [0.03%]
四环素类药物的人类嗜酸性粒细胞的强抗炎作用
Manuela Gehring,Dorothea Wieczorek,Alexander Kapp et al.
Manuela Gehring et al.
Eosinophils are potent pro-inflammatory cells. Not only in allergic diseases but also in other diseases there is a need for treatment strategies to induce resolution of eosinophil-mediated inflammation. During the last years beneficial non-...