Richard L Wasserman
Richard L Wasserman
Predicting first-time anaphylaxis in the elderly using stacked machine learning and population registers [0.03%]
基于堆叠机器学习和人口登记预测老年人首次过敏性休克
Toni Mora,David Roche,Rosa Muñoz-Cano
Toni Mora
Background: Anaphylaxis is a severe, potentially life-threatening allergic reaction that requires rapid identification and intervention. Predicting individuals at risk remains a clinical challenge due to its multifactoria...
Michael Jones,Hilary Shepherd,Diane Hatziioanou et al.
Michael Jones et al.
Introduction: Allergic rhinitis (AR) is a systemic respiratory condition that is associated with a considerable humanistic burden and is frequently underdiagnosed. Despite the known effects of AR on individual patient wel...
The epithelial barrier: a Janus-faced regulator in allergic airway diseases from defense to inflammation [0.03%]
上皮屏障：在过敏性气道疾病中从防御到炎症的两面调控者
Youwei Bao,Qi Chen,Binbin Shi et al.
Youwei Bao et al.
Background: The epithelial barrier serves as the body's first line of defense between the host immune system and the external environment. Evidence confirms that epithelial barrier damage is an initial event in the pathog...
Promoting immune defensive responses of epithelial cells in airway disease [0.03%]
气道疾病中诱导上皮细胞免疫防御作用的调控机制研究进展
Michael J Parnham,Virginia Norris,Jennifer A Kricker
Michael J Parnham
The airway epithelium serves as both a physical barrier and as an active contributor in maintaining immune defense. Upon exposure to external insults such as injury and infection, the epithelium releases alarmins including interleukin-25 (I...
Predictors of response to omalizumab and relapse in chronic spontaneous Urticaria: a narrative review focusing on parameters available in routine clinical practice [0.03%]
奥马珠单抗治疗慢性自发性荨麻疹疗效的预测因素及病情复发：基于常规临床实践参数的叙述性综述
Laura Mateu-Arrom,Xenevra Adriana Vence Nogueira,Lluis Puig et al.
Laura Mateu-Arrom et al.
Chronic spontaneous urticaria (CSU) is a heterogeneous disease with variable responses to treatment. Identifying predictors of response to omalizumab and relapse after its discontinuation is essential for optimizing management. This narrati...
Allergen immunotherapy for the control of moderate to severe allergic asthma: an evidence-based conjoint analysis to define candidate patient profiles in Spain and Portugal [0.03%]
基于证据的联合分析确定西班牙和葡萄牙中度至重度过敏性哮喘患者免疫治疗候选患者资料
J Delgado,R Cárdenas,S Gelis et al.
J Delgado et al.
Introduction: Allergen immunotherapy (AIT) is an effective and safe treatment; however, it is not recommended in consensus guidelines for severe allergic asthma patients. As AIT has been shown to be capable of modifying t...
Case Report: Sequential use of tezepelumab and mepolizumab for eosinophilic otitis media in EGPA: a steroid-sparing strategy [0.03%]
病例报告：TEZPELUMAB和美泊利单抗序贯治疗EGPA伴嗜酸性粒细胞性中耳炎：一种减少激素使用的策略
Osamu Matsuno,Masahiro Kawamoto,Tansri Wibowo et al.
Osamu Matsuno et al.
Even in eosinophilic granulomatosis with polyangiitis (EGPA), not all manifestations of eosinophilic inflammation respond equally to anti-interleukin-5 (IL-5) therapy. We report a case of steroid-refractory eosinophilic otitis media (EOM) i...
Case Report: Dupilumab combined with allergen-specific immunotherapy in severe atopic dermatitis and asthma [0.03%]
病例报告：度普利尤单抗联合特异性免疫疗法治疗重度特应性皮炎和哮喘患者
Galiya Tussupbekova,Dauren Tashenov,Aigul Syzdykova et al.
Galiya Tussupbekova et al.
We report a case of a 24-year-old man with long-standing, severe atopic dermatitis and partly controlled moderate bronchial asthma, marked type-2 inflammation and high molecular sensitization to house-dust mite and Alternaria allergens. Bec...
Case Report: Severe IgE-mediated hypersensitivity to carboxymethylcellulose with tolerance to crosscarmellose and microcrystalline cellulose [0.03%]
个例报告：严重的羧甲基纤维素IgE介导过敏反应对交联羧甲基纤维素和微晶纤维素不过敏
Rhea Schreiber,Carole Guillet
Rhea Schreiber
We present a rare case of severe IgE-mediated hypersensitivity to carboxymethylcellulose (CMC) following an intraarticular knee injection with triamcinolone acetonide (Triamcort®). The patient experienced a grade IV anaphylactic reaction s...