Revisiting the role of IL-1 signaling in the development of apical periodontitis [0.03%]
白细胞介素1信号在尖周炎发病中的作用再探
Kento Tazawa,Mariane Maffei Azuma Presse,Hisako Furusho et al.
Kento Tazawa et al.
Apical periodontitis (AP) develops as a result of an immune response to pulpal bacterial infection, and various cytokines are involved in the pathogenesis of AP, with Interleukin (IL)-1 being considered a key cytokine. The role of IL-1 in t...
DNA methylation differences in monozygotic twins with Van der Woude syndrome [0.03%]
同卵双生子中Van der Woude综合征的DNA甲基化差异
A L Petrin,E Zeng,M A Thomas et al.
A L Petrin et al.
Introduction: Van der Woude Syndrome (VWS) is an autosomal dominant disorder responsible for 2% of all syndromic orofacial clefts (OFCs) with IRF6 being the primary causal gene (70%). Cases may present with lip pits and e...
NG2/CSPG4 regulates cartilage degeneration during TMJ osteoarthritis [0.03%]
NG2/CSPG4在颞下颌关节骨性关节炎软骨退变中的调控作用
David A Reed,Yan Zhao,Mina Bagheri Varzaneh et al.
David A Reed et al.
Changes in the mechanical homeostasis of the temporomandibular joint (TMJ) can lead to the initiation and progression of degenerative arthropathies such as osteoarthritis (OA). Cells sense and engage with their mechanical microenvironment t...
Identifying oral disease variables associated with pneumonia emergence by application of machine learning to integrated medical and dental big data to inform eHealth approaches [0.03%]
通过应用机器学习整合医疗和牙科大数据来识别与肺炎发生相关的口腔疾病变量以促进e健康方法的应用
Neel Shimpi,Ingrid Glurich,Aloksagar Panny et al.
Neel Shimpi et al.
Background: The objective of this study was to build models that define variables contributing to pneumonia risk by applying supervised Machine Learning-(ML) to medical and oral disease data to define key risk variables c...
Daniel Clark,Allan Radaic,Yvonne Kapila
Daniel Clark
Increased age is associated with an increased prevalence of chronic inflammatory diseases and conditions. The term inflammaging has been used to describe the age-related changes to the immune response that results in a chronic and elevated ...
Sci-Seq of Human Fetal Salivary Tissue Introduces Human Transcriptional Paradigms and a Novel Cell Population [0.03%]
人类胎儿唾液组织的Sci-Seq分析揭示了人类转录范式和一种新的细胞群
Devon Duron Ehnes,Ammar Alghadeer,Sesha Hanson-Drury et al.
Devon Duron Ehnes et al.
Multiple pathologies and non-pathological factors can disrupt the function of the non-regenerative human salivary gland including cancer and cancer therapeutics, autoimmune diseases, infections, pharmaceutical side effects, and traumatic in...
Quantitative bone imaging biomarkers and joint space analysis of the articular Fossa in temporomandibular joint osteoarthritis using artificial intelligence models [0.03%]
人工智能模型在颞下颌关节骨关节炎中进行定量骨成像生物标志物和关节窝关节间隙分析
Tamara Mackie,Najla Al Turkestani,Jonas Bianchi et al.
Tamara Mackie et al.
Temporomandibular joint osteoarthritis (TMJ OA) is a disease with a multifactorial etiology, involving many pathophysiological processes, and requiring comprehensive assessments to characterize progressive cartilage degradation, subchondral...
Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort [0.03%]
多民族队列中牙结构异常和龋齿的多变量基因组-wide关联研究
Rasha N Alotaibi,Brian J Howe,Lina M Moreno Uribe et al.
Rasha N Alotaibi et al.
Odontogenesis is a complex process, where disruption can result in dental anomalies and/or increase the risk of developing dental caries. Based on previous studies, certain dental anomalies tend to co-occur in patients, suggesting that thes...
Evaluating the Effectiveness of Medical-Dental Integration to Close Preventive and Disease Management Care Gaps [0.03%]
评估医疗口腔整合的有效性以弥补预防和疾病管理中的护理缺口
David M Mosen,Matthew P Banegas,John F Dickerson et al.
David M Mosen et al.
Background: The integration of medical care into the dental setting has been shown to facilitate the closure of care gaps among patients with unmet needs. However, little is known about whether program effectiveness varie...
Perspective on Dentoalveolar Manifestations Resulting From PHOSPHO1 Loss-of-Function: A Form of Pseudohypophosphatasia? [0.03%]
关于由PHOSPHO1功能丧失导致的齿槽骨表现的观点：假性低磷酸酶症的一种形式？
Fatma F Mohamed,Michael B Chavez,Flavia Amadeu de Oliveira et al.
Fatma F Mohamed et al.
Mineralization of the skeleton occurs by several physicochemical and biochemical processes and mechanisms that facilitate the deposition of hydroxyapatite (HA) in specific areas of the extracellular matrix (ECM). Two key phosphatases, phosp...