Single Cell RNA Sequencing Reveals Human Tooth Type Identity and Guides In Vitro hiPSC Derived Odontoblast Differentiation (iOB) [0.03%]
单细胞RNA测序揭示人类牙齿类型特异性和体外hiPSC来源的成牙本质细胞分化的指导(iOB)
Sesha Hanson-Drury,Anjali P Patni,Deborah L Lee et al.
Sesha Hanson-Drury et al.
Over 90% of the U.S. adult population suffers from tooth structure loss due to caries. Most of the mineralized tooth structure is composed of dentin, a material produced and mineralized by ectomesenchyme derived cells known as odontoblasts....
Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism [0.03%]
盘状结构域受体：一个古老的胶原受体家族在骨骼发育、再生和代谢中起着重要作用
Renny T Franceschi,Shawn A Hallett,Chunxi Ge
Renny T Franceschi
The extracellular matrix (ECM) niche plays a critical role in determining cellular behavior during bone development including the differentiation and lineage allocation of skeletal progenitor cells to chondrocytes, osteoblasts, or marrow ad...
Role of mutans streptococci, acid tolerant bacteria and oral Candida species in predicting the onset of early childhood caries [0.03%]
变异链球菌，耐酸菌和口腔念珠菌属在预测早期儿童龋发病中的作用
Alissa Villhauer,Min Zhu,Wei Shi et al.
Alissa Villhauer et al.
Aim: Early childhood caries is the most common chronic infectious disease in children in the United States. This study, which is part of a larger, longitudinal study exploring oral microbiological components of caries dev...
Case Report: Dental Findings Can Aid in Early Diagnosis of APECED Syndrome [0.03%]
病例报告：牙科发现可帮助早期诊断APECED综合征
Laurie Brenchley,Elise M N Ferré,Monica M Schmitt et al.
Laurie Brenchley et al.
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type 1 (APS-1), is a rare genetic disorder caused most often by biallelic mutations in the AIRE gene. Classic clinical ...
Amelogenin Peptide-Chitosan Hydrogel for Biomimetic Enamel Regrowth [0.03%]
仿生牙釉质再生的牙源性蛋白衍生多肽-壳聚糖水凝胶体系研究
Kaushik Mukherjee,Amrita Chakraborty,Garima Sandhu et al.
Kaushik Mukherjee et al.
We designed synthetic peptides that have demonstrated an effective remineralization potential to restore incipient enamel decay. In order to develop a clinically viable approach we incorporated the amelogenin-derived peptides P26 and P32 in...
Prolyl-hydroxylase inhibitor-induced regeneration of alveolar bone and soft tissue in a mouse model of periodontitis through metabolic reprogramming [0.03%]
脯氨酰羟化酶抑制剂通过代谢重编程诱导牙周炎小鼠模型的牙槽骨和软组织再生
Elan Zebrowitz,Azamat Aslanukov,Tetsuhiro Kajikawa et al.
Elan Zebrowitz et al.
Bone injuries and fractures reliably heal through a process of regeneration with restoration to original structure and function when the gap between adjacent sides of a fracture site is small. However, when there is significant volumetric l...
Dhiraj Kumar,Robert D Bolskar,Isha Mutreja et al.
Dhiraj Kumar et al.
Current resin composites have favorable handling and upon polymerization initial physical properties that allow for efficient material replacement of removed carious tooth structure. Dental resin composites have long term durability limitat...
Engineering peptide-polymer hybrids for targeted repair and protection of cervical lesions [0.03%]
工程化肽-聚合物杂合体以靶向修复和保护宫颈病变区域
Paulette Spencer,Qiang Ye,Anil Misra et al.
Paulette Spencer et al.
By 2060, nearly 100 million people in the U.S. will be over age 65 years. One-third of these older adults will have root caries, and nearly 80% will have dental erosion. These conditions can cause pain and loss of tooth structure that inter...
Ida C Shaffer,Yukiko Nakano,Aidan Pham et al.
Ida C Shaffer et al.
In a systemic effort to survive environmental stress, organ systems fluctuate and adapt to overcome external pressures. The evolutionary drive back toward homeostasis makes it difficult to determine if an organism experienced a toxic exposu...
Integration of multimodal data in the developing tooth reveals candidate regulatory loci driving human odontogenic phenotypes [0.03%]
整合多模态数据揭示出候选调控位点并驱动人类牙发育表型
Emma Wentworth Winchester,Alexis Hardy,Justin Cotney
Emma Wentworth Winchester
Human odontogenic aberrations such as abnormal tooth number and delayed tooth eruption can occur as a symptom of rare syndromes or, more commonly, as nonsyndromic phenotypes. These phenotypes can require extensive and expensive dental treat...