Effects of Haloperidol on Cardiac Histamine H2 Receptors and β-Adrenoceptors in Isolated Mouse and Human Atrial Preparations [0.03%]
氟哌啶醇对小鼠和人心房组织组胺H2受体及β肾上腺素能受体的影响
Jonas M A Schlicht,Britt Hofmann,Uwe Kirchhefer et al.
Jonas M A Schlicht et al.
The antipsychotic drug haloperidol is found on the WHO list of essential drugs. In vitro, haloperidol demonstrates binding affinity for various receptors, including histamine H2 receptors (H2Rs). Several cardiac effects of haloperidol are k...
Ciro Manzo,Jordi Serra-Mestres,Marco Isetta
Ciro Manzo
Background: Systemic lupus erythematosus (SLE) is reported to be the most common rheumatological disorder associated with catatonia. To date, reports on catatonia manifestations in SLE patients are uncommon in published l...
From Fork to Brain: The Role of AGE-RAGE Signaling and the Western Diet in Neurodegenerative Disease [0.03%]
从饮食到大脑：西方饮食中AGE-RAGE信号转导在神经退行性疾病中的作用
Haylie J Pomroy,Arjun Mote,Simeon Mathew et al.
Haylie J Pomroy et al.
Advanced glycation end products (AGEs) are reactive compounds formed through non-enzymatic glycation in a process known as the Maillard reaction. While humans produce AGEs endogenously, these compounds can also enter the body through dietar...
Frailty in Stroke Care in Germany Between 2016 and 2022-A Retrospective, Hospital-Based Nationwide Cohort Study [0.03%]
2016至2022年德国卒中护理中的衰弱状况——一项基于医院的全国队列回顾性研究
Julius Dengler,Bassam Abdullah,Juraj Kukolja et al.
Julius Dengler et al.
This study examines changes in frailty among patients hospitalized for acute ischemic stroke (AIS) in a nationwide hospital cohort in Germany. Data from AIS patients were compared between the period before the corona virus disease 2019 (COV...
An Update on New Approaches to Cognitive Assessment in Multiple Sclerosis [0.03%]
多发性硬化症认知评估新方法的更新研究报告
Jacob Balconi,Dawn Langdon,Bishal Dhakal et al.
Jacob Balconi et al.
Accessible, dependable cognitive assessment is integral to patient care of people with multiple sclerosis (PwMS). Traditional neuropsychological tests are well validated in the multiple sclerosis (MS) population, but not without limitations...
Accuracy of the Mini-Mental State Examination and Montreal Cognitive Assessment in Detecting Cognitive Impairment in Older Adults: A Comparative Study Adjusted for Educational Level [0.03%]
校正教育水平后的简易智能状态检查和蒙特利尔认知评估识别老年人认知障碍的准确性：一项比较研究
Paula Andreatta Maduro,Leandro Paim da Cruz Carvalho,Luiz Alcides Ramires Maduro et al.
Paula Andreatta Maduro et al.
Early detection of cognitive decline in older adults is essential for implementing timely interventions. This study aimed to compare the diagnostic accuracy of the Mini-Mental State Examination (MMSE®) and the Montreal Cognitive Assessment...
Laurent Goffart
Laurent Goffart
The static orientation of the eyes during visual fixation is determined by the simultaneous operation of multiple equilibria. This phenomenon is collectively referred to as poly-equilibrium, which involves multiple systems that work togethe...
Jorge Manzo,María Elena Hernández-Aguilar,María Rebeca Toledo-Cárdenas et al.
Jorge Manzo et al.
Autism Spectrum Disorder presents one of the most complex challenges in contemporary neuroscience. This review adopts an unconventional narrative structure, drawing inspiration from song titles by The Beatles to explore the multifaceted bio...
Ketamine's Therapeutic Role in Substance Use Disorders: A Narrative Review [0.03%]
氯胺酮在物质使用障碍治疗中的作用：叙述性综述
Alexander Thomas,R Andrew Chambers
Alexander Thomas
Interest in ketamine as a novel treatment for substance use disorders (SUDs) has been increasing due to its N-methyl-D-aspartate (NMDA) glutamate receptor antagonism and mounting evidence that glutamate neurotransmission is involved in the ...
The Impact of Multiple Sclerosis on Work Productivity: A Preliminary Look at the North American Registry for Care and Research in Multiple Sclerosis [0.03%]
多发性硬化症对工作生产力的影响：来自北美多发性硬化护理和研究登记处的初步观察结果
Ahya Ali,Kottil Rammohan,June Halper et al.
Ahya Ali et al.
Objective: We aimed to quantify multiple sclerosis (MS)-related work productivity and to illustrate the longitudinal trends for relapses, disease progression, and utilization of health care resources in a nationally repre...