Enhancing nucleic acid delivery by the integration of artificial intelligence into lipid nanoparticle formulation [0.03%]
人工智能在脂质纳米颗粒配方中的整合以增强核酸递送
Kagya Amoako,Amir Mokhammad,Afrida Malik et al.
Kagya Amoako et al.
The advent of messenger RNA (mRNA) therapeutics has revolutionized medicine, with its potential underscored by rapid advancements during the COVID-19 pandemic. Despite its promise, nucleic acid delivery remains a formidable challenge due to...
Deep learning for MRI-based acute and subacute ischaemic stroke lesion segmentation-a systematic review, meta-analysis, and pilot evaluation of key results [0.03%]
基于MRI的急性及亚急性的卒中病变分割的深度学习系统性综述、元分析和初步评估关键结果研究
Makram Baaklini,Maria Del C Valdés Hernández
Makram Baaklini
Background: Segmentation of ischaemic stroke lesions from magnetic resonance images (MRI) remains a challenging task mainly due to the confounding appearance of these lesions with other pathologies, and variations in thei...
Hyperspectral abdominal laparoscopy with real-time quantitative tissue oxygenation imaging: a live porcine study [0.03%]
一种实时定量组织氧合成像的超光谱腹腔镜在活体猪身上的应用研究
Oscar MacCormac,Conor C Horgan,Dale Waterhouse et al.
Oscar MacCormac et al.
Background: Ischaemia is a critical complication, and can result in poor surgical outcomes. While intra-operative overt ischaemia can be perceived with the naked eye, timely recognition of borderline perfusion can prevent...
Regulatory landscape of accelerated approval pathways for medical devices in the United States and the European Union [0.03%]
美国和欧洲联盟医疗器械加速审批途径的监管格局
Tanvi Gupte,Tushar Nitave,Jogarao Gobburu
Tanvi Gupte
The landscape of medical device regulation is rapidly evolving, driven by innovations and the need to bring these technologies to patients more efficiently. This review provides a comprehensive analysis of the accelerated access pathways fo...
Comparative evaluation of accuracy, precision, and radiation dose between mindways and low-dose iCare QCT for lumbar spine BMD using the European spine phantom [0.03%]
欧洲脊柱模型下评估Mindways和低剂量iCare QCT用于腰椎骨密度检测的准确性、精确性和辐射剂量的比较研究
Yujie Li,Tiantian Yin,Qiushi Yang et al.
Yujie Li et al.
Background: Quantitative computed tomography (QCT) has received growing attention for its utility in bone mineral density (BMD) assessment and osteoporosis diagnosis. ...
Regulatory aspects of optogenetic research and therapy for retinitis pigmentosa under EU law [0.03%]
欧盟法律下的视网膜母细胞瘤光学基因治疗的研究与监管方面的问题
Johannes Freise
Johannes Freise
Optogenetics has potentials for a treatment of retinitis pigmentosa and other rare degenerative retinal diseases. The technology allows controlling cell activity through combining genetic engineering and optical stimulation with light. Firs...
Molecular diagnostic methods for rapid diagnosis of central nervous system infections [0.03%]
中枢神经系统感染的分子诊断方法
Mallikarjuna Pedduru Venkatareddy,Dinesh Upadhya,Prakash Peralam Yegneswaran et al.
Mallikarjuna Pedduru Venkatareddy et al.
Central nervous system infections (CNSI) are serious life-threatening conditions caused by bacteria, viruses, fungi, and parasites and lead to high morbidity and mortality worldwide. Therefore, rapid identification of causative organisms an...
Drug coated balloons in percutaneous coronary intervention: how can computational modelling help inform evolving clinical practice? [0.03%]
药物涂层 balloon 在经皮冠状动脉介入治疗中的应用：计算模型如何帮助指导临床实践？
Silvia Renon,Rafic Ramses,Ankush Aggarwal et al.
Silvia Renon et al.
Drug-coated balloons (DCB) represent an emerging therapeutic alternative to drug-eluting stents (DES) for the treatment of coronary artery disease (CAD). Among the key advantages of DCB over DES are the absence of a permanent structure in t...
Advanced computational tools, artificial intelligence and machine-learning approaches in gut microbiota and biomarker identification [0.03%]
肠道微生物组和生物标志物识别的高级计算工具、人工智能及机器学习方法
Tikam Chand Dakal,Caiming Xu,Abhishek Kumar
Tikam Chand Dakal
The microbiome of the gut is a complex ecosystem that contains a wide variety of microbial species and functional capabilities. The microbiome has a significant impact on health and disease by affecting endocrinology, physiology, and neurol...
Drilling around the corner: a comprehensive literature review of steerable bone drills [0.03%]
拐角钻孔：可操控骨钻文献综述
Esther P de Kater,Paul Breedveld,Aimée Sakes
Esther P de Kater
Introduction: Orthopedic procedures often require drilling of tunnels through bone, for instance for the introduction of implants. The currently used rigid bone drills make it challenging to reach all target areas without...