Leora Duong,Steven P Gross,Albert Siryaporn
Leora Duong
Antimicrobial peptides (AMPs) have been extensively studied due to their vast natural abundance and ability to kill microbes. In an era critically lacking in new antibiotics, manipulating AMPs for therapeutic application is a promising opti...
Dengue Virus and Vaccines: How Can DNA Immunization Contribute to This Challenge? [0.03%]
登革病毒与疫苗：DNA免疫如何应对挑战？
Ada Maria Barcelos Alves,Simone Morais Costa,Paolla Beatriz Almeida Pinto
Ada Maria Barcelos Alves
Dengue infections still have a tremendous impact on public health systems in most countries in tropical and subtropical regions. The disease is systemic and dynamic with broad range of manifestations, varying from mild symptoms to severe de...
Declan C Mullen,Xing Wan,Timo M Takala et al.
Declan C Mullen et al.
The overall expectation from an antimicrobial surface has been high considering the need for efficiency in preventing the attachment and growth of pathogenic microbes, durability, safety to both humans and environment as well as cost-effect...
Multiple Sclerosis: LIFNano-CD4 for Trojan Horse Delivery of the Neuro-Protective Biologic "LIF" Into the Brain: Preclinical Proof of Concept [0.03%]
利用携带神经营养生物药物"LIF"的“特洛伊给药系统”治疗多发性硬化症：前期概念验证试验
Raul de la Flor,Janette Robertson,Rostislav V Shevchenko et al.
Raul de la Flor et al.
Multiple sclerosis (MS) is a demyelinating autoimmune disease that attacks the brain, with year-on-year loss of brain volume, starting late teens and becoming manifest late twenties. There is no cure, and current therapies are immunosuppres...
Efficacy, Safety, and Economics of Innovative Medicines: The Role of Multi-Criteria Decision Analysis and Managed Entry Agreements in Practice and Policy [0.03%]
创新药物的有效性、安全性和经济性：实践和政策中多准则决策分析和管理入市协议的作用
Tanja Fens,Eugène P van Puijenbroek,Maarten J Postma
Tanja Fens
Through the years, solutions for accelerated access to innovative treatments are implemented in models of regulatory approvals, yet with limited data. Besides efficacy data, providing adequate safety data is key to transferring conditional ...
Modeling Cell Selectivity of Antimicrobial Peptides: How Is the Selectivity Influenced by Intracellular Peptide Uptake and Cell Density [0.03%]
抗菌肽选择性作用于细胞的建模研究：胞内肽摄取和细胞密度是如何影响选择性的
Bethany R Schefter,Shokoofeh Nourbakhsh,Sattar Taheri-Araghi et al.
Bethany R Schefter et al.
Antimicrobial peptides (AMPs) are known to attack bacteria selectively over their host cells. Many attempts have been made to use them as a template for designing peptide antibiotics for fighting drug-resistant bacteria. A central concept i...
Bridging the Antimicrobial Activity of Two Lactoferricin Derivatives in E. coli and Lipid-Only Membranes [0.03%]
两种乳铁素衍生物在E. coli和脂质膜上抗菌活性的桥接关系研究
Lisa Marx,Enrico F Semeraro,Johannes Mandl et al.
Lisa Marx et al.
We coupled the antimicrobial activity of two well-studied lactoferricin derivatives, LF11-215 and LF11-324, in Escherichia coli and different lipid-only mimics of its cytoplasmic membrane using a common thermodynamic framework for peptide p...
Byron J Lambert,Joyce M Hansen,Trabue D Bryans et al.
Byron J Lambert et al.
The sterility assurance community is facing significant challenges. A relatively recent challenge is the pressure on manufacturing supply chains resulting from the limited availability of capacity for terminal sterilization of healthcare pr...
Antibiotic Potential and Biophysical Characterization of Amphipathic β-Stranded [XZ]n Peptides With Alternating Cationic and Hydrophobic Residues [0.03%]
具有交替阳离子和疏水残基的两性β折叠[XZ]n肽的抗菌活性及生物物理性质研究
Erik Strandberg,Parvesh Wadhwani,Anne S Ulrich
Erik Strandberg
Cationic membrane-active peptides are considered to be promising candidates for antibiotic treatment. Many natural and artificial sequences show an antimicrobial activity when they are able to take on an amphipathic fold upon membrane bindi...
A Psychometric Platform to Collect Somatosensory Sensations for Neuroprosthetic Use [0.03%]
用于神经假体的感觉心理测量平台收集somatosensory感觉状态
Giacomo Valle,Francesco Iberite,Ivo Strauss et al.
Giacomo Valle et al.
Somatosensory neuroprostheses exploit invasive and non-invasive feedback technologies to restore sensorimotor functions lost to disease or trauma. These devices use electrical stimulation to communicate sensory information to the brain. A s...