Detection of natural autoimmunity to ghrelin in diabetes mellitus [0.03%]
糖尿病患者中自然获得的针对生长素释放肽的自身免疫反应的检测
Rega H Kasim,Thilo Samson Chillon,Anna Maria Eleftheriadou et al.
Rega H Kasim et al.
Objective: Ghrelin is an orexigenic peptide that becomes post-translationally modified. Natural autoantibodies to ghrelin (ghrelin-aAb) have been described in healthy subjects, in eating disorders and rheumatic diseases, ...
Ensuring safety and efficacy in combination products: regulatory challenges and best practices [0.03%]
组合产品安全与效能的保障：监管挑战及最佳实践
Deepak Kumar Gupta,Akhilesh Tiwari,Yashraj Yadav et al.
Deepak Kumar Gupta et al.
Combination products, amalgamating drugs, biologics, and medical devices, have revolutionized the healthcare landscape with their potential for innovative therapies. However, the intersection of diverse components within these products pres...
Augmented reality-based software (Echo-QR) for guiding the echographic probe toward the acoustic window: a pilot study [0.03%]
基于增强现实的软件（Echo-QR）引导超声探头走向声学窗口：一项初步研究
A Thevenon,F Derache,O Faucoz et al.
A Thevenon et al.
Introduction: With current technology, ultrasound imaging in remote conditions, such as the International Space Station, is performed with vocal guidance or using a teleoperated echograph controlled by an expert. Both met...
Fluid-structure interaction simulation of mechanical aortic valves: a narrative review exploring its role in total product life cycle [0.03%]
机械主动脉瓣的流固耦合仿真：全面探究其在产品全生命周期中的作用
Mariachiara Arminio,Dario Carbonaro,Umberto Morbiducci et al.
Mariachiara Arminio et al.
Over the last years computer modelling and simulation has emerged as an effective tool to support the total product life cycle of cardiovascular devices, particularly in the device preclinical evaluation and post-market assessment. Computat...
Ethical considerations in the regulation and use of herbal medicines in the European Union [0.03%]
欧盟草药监管和使用的伦理考量
Anthony Raphael Gatt,Patricia Vella Bonanno,Raymond Zammit
Anthony Raphael Gatt
The regulation and use of herbal medicines is a topic of debate due to concerns about their quality, safety, and efficacy. EU Directive 2004/24/EC on Herbal Medicinal Products was a significant step towards establishing a regulatory framewo...
Development of bedaquiline nanoemulsions intended for paediatric multidrug-resistant tuberculosis: excipient selection and preformulation studies [0.03%]
用于儿童多药耐药结核病的贝达喹啉纳米乳剂的发展：辅料选择和预制剂研究
Taiwo Oreoluwa Ajayi,Madan Sai Poka,Bwalya Angel Witika
Taiwo Oreoluwa Ajayi
Preformulation investigations into the development of drug formulations, encompassing considerations related to the structure of the drug, excipients, composition, and physical attributes are crucial. This phase is pivotal in ensuring the u...
Editorial: New technologies improve maternal and newborn safety [0.03%]
editorial: 新技术改善了孕产妇和新生儿的安全性
Jieyun Bai,Yaosheng Lu,Huishu Liu et al.
Jieyun Bai et al.
Influence of sports on cortical excitability in patients with spinal cord injury: a TMS study [0.03%]
体育运动对脊髓损伤患者皮质兴奋性的影响：一种经颅磁刺激研究
Vanessa N Frey,Patrick B Langthaler,Nora Renz et al.
Vanessa N Frey et al.
Background: Patients with spinal cord injury (SCI) show abnormal cortical excitability that might be caused by deafferentation. We hypothesize a reduced short-interval intracortical inhibition preceding movement in patien...
Experimental validation of auxetic stent designs: three-point bending of 3D printed Titanium prototypes [0.03%]
体外实验验证多孔减应区支架的力学性能：3D打印钛合金支架的三点弯曲实验研究
Rahul Vellaparambil,Woo-Suck Han,Pierluigi Di Giovanni et al.
Rahul Vellaparambil et al.
Introduction: Numerical simulations have demonstrated the superior bending flexibility of auxetic stents compared to conventional stent designs for endovascular procedures. However, conventional stent manufacturing techni...
Huang Chen,Milad Samaee,Michael Tree et al.
Huang Chen et al.
This study aims to evaluate the fluid dynamic characteristics of the VenusP Valve System™ under varying cardiac outputs in vitro. A thorough hemodynamic study of the valve under physiological cardiac conditions was conducted and served as ...