Xiong Li,Shengyi Lu,Boxun Lu et al.
Xiong Li et al.
The GGGGCC (G4C2) hexanucleotide repeat expansion in the C9ORF72 gene is a major cause of both hereditary amyotrophic lateral sclerosis and familial frontotemporal dementia. Recent studies have shown that G4C2 hexanucleotide repeat-containi...
The physiological and pathological mechanisms of early embryonic development [0.03%]
早期胚胎发育的生理和病理机制研究进展
Jian Mu,Zhou Zhou,Qing Sang et al.
Jian Mu et al.
Early embryonic development is a complex process. The zygote undergoes several rounds of division to form a blastocyst, and during this process, the zygote undergoes the maternal-to-zygotic transition to gain control of embryonic developmen...
Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy [0.03%]
乌特罗非ン替代杜荆指蛋白治疗杜氏肌营养不良的前景展望
Ruo Wu,Yafeng Song,Shiwen Wu et al.
Ruo Wu et al.
Duchenne muscular dystrophy (DMD) is a serious genetic neuromuscular rare disease that is prevalent and caused by the mutation/deletion of the X-linked DMD gene that encodes dystrophin. Utrophin is a dystrophin homologous protein on human c...
Electroreduction of carbon dioxide to multi-electron reduction products using poly(ionic liquid)-based Cu-Pd catalyst [0.03%]
基于离子液体聚合物的Cu-Pd催化剂选择性二氧化碳多电子还原反应制备C2+产物
Xiao-Qiang Li,Guo-Yi Duan,Xian-Xia Yang et al.
Xiao-Qiang Li et al.
Electrocatalytic reduction of CO2 (CO2RR) to multi-electron (> 2e-) products provides a green and sustainable route for producing fuels and chemicals. Introducing the second metal element is a feasible strategy for "managing" the key interm...
Haplotype-resolved Chinese male genome assembly based on high-fidelity sequencing [0.03%]
基于高保真测序的单倍体型解析的中国男性基因组组装
Xiaofei Yang,Xixi Zhao,Shoufang Qu et al.
Xiaofei Yang et al.
The advantages of both the length and accuracy of high-fidelity (HiFi) reads enable chromosome-scale haplotype-resolved genome assembly. In this study, we sequenced a cell line named HJ, established from a Chinese Han male individual by usi...
Rare and undiagnosed diseases: From disease-causing gene identification to mechanism elucidation [0.03%]
罕见病和未诊断疾病：从致病基因鉴定到发病机制解析
Gang Wang,Yuyan Xu,Qintao Wang et al.
Gang Wang et al.
Rare and undiagnosed diseases substantially decrease patient quality of life and have increasingly become a heavy burden on healthcare systems. Because of the challenges in disease-causing gene identification and mechanism elucidation, pati...
Plant-protein-enabled biodegradable triboelectric nanogenerator for sustainable agriculture [0.03%]
一种基于植物蛋白的可降解摩擦纳米发电机用于可持续农业
Chengmei Jiang,Qi Zhang,Chengxin He et al.
Chengmei Jiang et al.
As the use of triboelectric nanogenerators (TENGs) increases, the generation of related electronic waste has been a major challenge. Therefore, the development of environmentally friendly, biodegradable, and low-cost TENGs must be prioritiz...
Wide-spectrum polarization-sensitive and fast-response photodetector based on 2D group IV-VI semiconductor tin selenide [0.03%]
基于二维IV-VI族半导体硒化锡的宽带隙偏振敏感型快速响应光电探测器
Yali Yu,Tao Xiong,Zhengfeng Guo et al.
Yali Yu et al.
Tin selenide (SnSe) has attracted considerable interest recently on account of its low-symmetry lattice structure, great compatibility with key semiconductor technology, and remarkable electrical and optical performance. SnSe-based polariza...
Online single-shot characterization of ultrafast pulses from high-gain free-electron lasers [0.03%]
高增益自由电子激光飞秒脉冲的在线表征方法研究
Li Zeng,Chao Feng,Duan Gu et al.
Li Zeng et al.
X-ray free-electron lasers (FELs) provide cutting-edge tools for fundamental researches to study nature down to the atomic level at a time-scale that fits this resolution. A precise knowledge of temporal information of FEL pulses is the cen...
Opportunities and challenges of rare and undiagnosed disease research in China [0.03%]
我国罕见病和疑难病研究的机遇与挑战
Lei Wang,Zhihong Liu,Guang Ning et al.
Lei Wang et al.