Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2 [0.03%]
SARS-CoV-2 RNA依赖性RNA聚合酶的反应机制研究
Juan Aranda,Milosz Wieczór,Montserrat Terrazas et al.
Juan Aranda et al.
We combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular mechanics simulations to describe mechanistically the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (Rd...
Combinatorial pathway balancing provides biosynthetic access to 2-fluoro- cis, cis-muconate in engineered Pseudomonas putida [0.03%]
组合途径平衡可利用工程假单胞菌(Pseudomonas putida)获得2-氟顺式顺式穆聪酸的生物合成通道
Nicolas T Wirth,Pablo I Nikel
Nicolas T Wirth
The wealth of bio-based building blocks produced by engineered microorganisms seldom include halogen atoms. Muconate is a platform chemical with a number of industrial applications that could be broadened by introducing fluorine atoms to tu...
Organometallic AlaM Reagents for Umpolung Peptide Diversification [0.03%]
用于肽类 umpolung 多样化的有机金属 AlaM 试剂
Feng Zhu,Wyatt C Powell,Ruiheng Jing et al.
Feng Zhu et al.
Selective modifications of peptides and proteins have emerged as a promising strategy to develop novel mechanistic probes and prepare compounds with translational potentials. Here, we report alanine carbastannatranes AlaSn as a universal sy...
Perfluorocarbon Nanoemulsions Create a Beneficial O2 Microenvironment in N2-fixing Biological | Inorganic Hybrid [0.03%]
全氟碳纳米乳液在固氮生物中创造有利的O2微环境| 生物-无机杂化体
Shengtao Lu,Roselyn M Rodrigues,Shuyuan Huang et al.
Shengtao Lu et al.
Powered by renewable electricity, biological | inorganic hybrids employ water-splitting electrocatalysis and generate H2 as reducing equivalents for microbial catalysis. The approach integrates the beauty of biocatalysis with the energy eff...
Chemo- and Stereoselective Intermolecular [2+2] Photocycloaddition of Conjugated Dienes using Colloidal Nanocrystal Photocatalysts [0.03%]
利用胶体纳米晶光催化剂选择性地进行共轭二烯的[2+2]光环加成反应
Yishu Jiang,Muwen Yang,Yue Wu et al.
Yishu Jiang et al.
The use of visible-light photosensitizers to power [2+2] photocycloadditions that produce complex tetrasubstituted cyclobutanes is a true success of photochemistry, but the scope of this reaction has been limited to activated α, β-unsatur...