Photosensitized Activation of Diazonium Derivatives for C-B Bond Formation [0.03%]
光敏活化偶氮衍生物的C-B键形成反应
Alexia Ripak,Simon De Kreijger,Renato N Sampaio et al.
Alexia Ripak et al.
Aryl diazonium salts are ubiquitous building blocks in chemistry, as they are useful radical precursors in organic synthesis as well as for the functionalization of solid materials. They can be reduced electrochemically or through a photo-i...
Wenzhen Fu,Yang Yang
Wenzhen Fu
Selective catalytic functionalization of C(sp 3)-H bonds represents a powerful means to access valuable products from ubiquitous starting materials. In a recent JACS paper, Arnold and co-workers engineered P450 nitrene transferases to amina...
Heather Hintz,Jamey Bower,Jinghua Tang et al.
Heather Hintz et al.
We report the systematic development of an electrooxidative methodology that translates stoichiometric C-H fluorination reactivity of an isolable CuIII fluoride complex into a catalytic process. The critical challenges of electrocatalysis w...
Multiscale simulation-guided design of enzyme bioconjugates with enhanced catalysis [0.03%]
多尺度模拟引导的酶生物偶联物的增强催化设计
Xiao Hong,Timothy Cholko,Chia-En A Chang et al.
Xiao Hong et al.
Biopolymer-scaffold modification is widely used to enhance enzyme catalysis. A central challenge is predicting the effects of scaffold position on enzyme properties. Here, we use a computational-experimental approach to develop a model for ...
Analysis of Laboratory-Evolved Flavin-Dependent Halogenases Affords a Computational Model for Predicting Halogenase Site Selectivity [0.03%]
分析实验室进化 flavin依赖卤化酶得到预测卤化酶位点选择性的计算模型
Mary C Andorfer,Declan Evans,Song Yang et al.
Mary C Andorfer et al.
Flavin-dependent halogenases (FDHs) catalyze selective halogenation of electron-rich aromatic compounds without the need for harsh oxidants required by conventional oxidative halogenation reactions. Predictive models for halogenase site sel...
Yanlong Jiang,Hans Renata
Yanlong Jiang
Many enzymes possess high catalytic efficiency and selectivity that far surpass classical organic or organometallic catalysts. However, the initial starting enzyme for a given transformation does not always possess the right properties need...
Katie A Spence,Arismel Tena Meza,Neil K Garg
Katie A Spence
Strained intermediates such as cyclic alkynes and allenes are most commonly utilized in nucleophilic additions and cycloadditions, but have seen increased use in a third area of reactivity: metal-mediated transformations. The merger of stra...
Thianthrenium-Enabled Sulfonylation via Electron Donor-Acceptor Complex Photoactivation [0.03%]
通过电子给体-受体复合物光活化使噻蒽鎓
Albert Granados,María Jesús Cabrera-Afonso,Marcos Escolano et al.
Albert Granados et al.
Sulfone-containing compounds are prevalent building blocks in pharmaceuticals and other biomolecules, and they serve as key intermediates in the synthesis of complex scaffolds. During the past decade, several methods have been developed to ...
Christopher Uyeda,Annah E Kalb
Christopher Uyeda
Efforts to develop catalytic carbene transfer reactions have largely relied on the use of diazo precursors. However, diazoalkanes are susceptible to undergoing violent exothermic decomposition unless they contain stabilizing substituents. C...
Radical differentiation of two ester groups in unsymmetrical diazomalonates for highly asymmetric olefin cyclopropanation [0.03%]
不对称二氮杂茋酯的激进区分用于烯烃高对映选择性环丙烷化反应
Jingyi Wang,Jingjing Xie,Wan-Chen Cindy Lee et al.
Jingyi Wang et al.
Diazomalonates have been demonstrated as effective metalloradicophiles for asymmetric radical olefin cyclopropanation via Co(II)-metalloradical catalysis (MRC). Supported by D 2-symmetric chiral amidoporphyrin ligand, Co(II)-based metallora...