Katie A Spence,Arismel Tena Meza,Neil K Garg
Katie A Spence
Strained intermediates such as cyclic alkynes and allenes are most commonly utilized in nucleophilic additions and cycloadditions, but have seen increased use in a third area of reactivity: metal-mediated transformations. The merger of stra...
Thianthrenium-Enabled Sulfonylation via Electron Donor-Acceptor Complex Photoactivation [0.03%]
通过电子给体-受体复合物光活化使噻蒽鎓
Albert Granados,María Jesús Cabrera-Afonso,Marcos Escolano et al.
Albert Granados et al.
Sulfone-containing compounds are prevalent building blocks in pharmaceuticals and other biomolecules, and they serve as key intermediates in the synthesis of complex scaffolds. During the past decade, several methods have been developed to ...
Christopher Uyeda,Annah E Kalb
Christopher Uyeda
Efforts to develop catalytic carbene transfer reactions have largely relied on the use of diazo precursors. However, diazoalkanes are susceptible to undergoing violent exothermic decomposition unless they contain stabilizing substituents. C...
Radical differentiation of two ester groups in unsymmetrical diazomalonates for highly asymmetric olefin cyclopropanation [0.03%]
不对称二氮杂茋酯的激进区分用于烯烃高对映选择性环丙烷化反应
Jingyi Wang,Jingjing Xie,Wan-Chen Cindy Lee et al.
Jingyi Wang et al.
Diazomalonates have been demonstrated as effective metalloradicophiles for asymmetric radical olefin cyclopropanation via Co(II)-metalloradical catalysis (MRC). Supported by D 2-symmetric chiral amidoporphyrin ligand, Co(II)-based metallora...
Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2 [0.03%]
SARS-CoV-2 RNA依赖性RNA聚合酶的反应机制研究
Juan Aranda,Milosz Wieczór,Montserrat Terrazas et al.
Juan Aranda et al.
We combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular mechanics simulations to describe mechanistically the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (Rd...
Combinatorial pathway balancing provides biosynthetic access to 2-fluoro- cis, cis-muconate in engineered Pseudomonas putida [0.03%]
组合途径平衡可利用工程假单胞菌(Pseudomonas putida)获得2-氟顺式顺式穆聪酸的生物合成通道
Nicolas T Wirth,Pablo I Nikel
Nicolas T Wirth
The wealth of bio-based building blocks produced by engineered microorganisms seldom include halogen atoms. Muconate is a platform chemical with a number of industrial applications that could be broadened by introducing fluorine atoms to tu...
Organometallic AlaM Reagents for Umpolung Peptide Diversification [0.03%]
用于肽类 umpolung 多样化的有机金属 AlaM 试剂
Feng Zhu,Wyatt C Powell,Ruiheng Jing et al.
Feng Zhu et al.
Selective modifications of peptides and proteins have emerged as a promising strategy to develop novel mechanistic probes and prepare compounds with translational potentials. Here, we report alanine carbastannatranes AlaSn as a universal sy...
Perfluorocarbon Nanoemulsions Create a Beneficial O2 Microenvironment in N2-fixing Biological | Inorganic Hybrid [0.03%]
全氟碳纳米乳液在固氮生物中创造有利的O2微环境| 生物-无机杂化体
Shengtao Lu,Roselyn M Rodrigues,Shuyuan Huang et al.
Shengtao Lu et al.
Powered by renewable electricity, biological | inorganic hybrids employ water-splitting electrocatalysis and generate H2 as reducing equivalents for microbial catalysis. The approach integrates the beauty of biocatalysis with the energy eff...
Chemo- and Stereoselective Intermolecular [2+2] Photocycloaddition of Conjugated Dienes using Colloidal Nanocrystal Photocatalysts [0.03%]
利用胶体纳米晶光催化剂选择性地进行共轭二烯的[2+2]光环加成反应
Yishu Jiang,Muwen Yang,Yue Wu et al.
Yishu Jiang et al.
The use of visible-light photosensitizers to power [2+2] photocycloadditions that produce complex tetrasubstituted cyclobutanes is a true success of photochemistry, but the scope of this reaction has been limited to activated α, β-unsatur...