Ann Varghese,Sodiq O Waheed,Shobhit S Chaturvedi et al.
Ann Varghese et al.
The fat-mass and obesity-associated protein (FTO) is a Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase of the AlkB family and is linked with obesity and cancer. The enzyme is identified as single-stranded DNA/RNA demethylase with N6-met...
Copper-Catalyzed 1,4-Aminohydroxylation and Aminothiolation of 1,3-Dienes by Carbonyl-Assisted Migration [0.03%]
羰基辅助迁移铜催化1,3-丁二烯的1,4-amination氧化和加硫反应
Noah H Watkins,Yungeun Kwon,Qiu Wang
Noah H Watkins
We report a copper-catalyzed 1,4-selective aminooxygenation of 1,3-dienes as a direct entry to 1,4-allylic amino alcohols. The reactions are effective on a diverse range of amide, urea, and ester-containing 1,3-dienes, allowing for facile i...
Enantioselective synthesis of axially chiral P-containing allenes for allenyl chirality [0.03%]
手性P原子轴不对称联二烯的对映选择性合成及其联二烯手性的应用研究
Guangshou Feng,Qiu Wang
Guangshou Feng
In this issue of Chem Catalysis, Wang J. and co-workers have established an efficient and practical route to construct versatile di-, tri-, and tetra-substituted phosphoryl allenes via a nickel-catalyzed propargylic substitution reaction, o...
Expanding the repertoire of imine reductases by mining divergent biosynthetic pathways for promiscuous reactivity [0.03%]
通过挖掘发散的生物合成途径来扩展亚胺还原酶的多样性反应库
Godwin A Aleku,Florian Hollfelder
Godwin A Aleku
Imine reductases (IREDs) are invaluable catalysts for enantioselective imine reduction and reductive amination of carbonyl compounds. Their synthetic versatility is, however, limited by their substrate scope, and new IREDs are needed. Curre...
Chiral pyrrolidines via an enantioselective Hofmann-Löffler-Freytag reaction [0.03%]
手性吡咯烷的霍夫曼-洛弗尔-弗莱塔反应法合成
Pavitra Laohapaisan,Ipshita Roy,David A Nagib
Pavitra Laohapaisan
Radical C-H aminations enable rapid access to the most common heterocycles in medicines (e.g. pyrrolidines), yet stereocontrol of these powerful transformations remains a challenge. Here, we report the discovery of the first enantio- and re...
Visible Light-Driven Excited-State Copper-BINAP Catalysis for Accessing Diverse Chemical Reactions [0.03%]
可见光驱动激发态铜-BINAP催化多样性化学反应
Upasana Mukherjee,Jagrut A Shah,Ming-Yu Ngai
Upasana Mukherjee
The use of visible light to drive chemical transformations has a history spanning over a century. However, the development of photo-redox catalysts to efficiently harness light energy is a more recent advancement, evolving over the past two...
Mohamed Ateia,Ashley Hesterberg Butzlaff
Mohamed Ateia
Mohamed Ateia Ibrahim (environmental engineer and group leader at the US Environmental Protection Agency and adjunct assistant professor at Rice University) and Ashley Hesterberg Butzlaff (environmental engineer at the US Environmental Prot...
Maia E Czaikowski,Sophie W Anferov,John S Anderson
Maia E Czaikowski
Electrochemistry has been an increasingly useful tool for organic synthesis, as it can selectively generate reactive intermediates under mild conditions using an applied potential. Concurrently, synergistic activity of a metal and a ligand ...
Steric Modulation of CAACs Controls Orientation and Ethenolysis Performance [0.03%]
CAACs的立体调控控制着取向和乙醇性能
Katrina H Jensen,Brian W Michel
Katrina H Jensen
In this issue of Chem Catalysis, Sytniczuk, Kajetanowicz, and Grela report sterically tuned Cyclic(Alkyl)(Amino)Carbene (CAAC) ligands to protect the requisite Ru-methylidene ([Ru]=CH2) intermediate present during ethenolysis of renewable f...
Targeted Enzyme Modifications Enable Regioselective Biosynthesis of Fluorinated Polyketides [0.03%]
靶向酶修饰实现氟化聚酮类化合物的区域选择性生物合成
Sydney D Welch,Jared Cossin,Thaddeus Q Paulsel et al.
Sydney D Welch et al.
In attempts to enhance natural products as therapeutic agents, fluorination has emerged as a new tool for synthetic biologists and chemists. In recent articles published in Nature Chem. and Nature Chem. Bio., Grininger, Chang, and co-worker...