The effect of renin-angiotensin-aldosterone system inhibitors in patients with hypertension and COVID-19: A meta-analysis of randomized controlled trials and propensity score-matched studies [0.03%]
抑制肾素-血管紧张素-醛固酮系统的药物在高血压合并新冠肺炎患者中的应用：随机对照试验和倾向性评分匹配研究的汇总分析
Kai Zhang,Lanxin Cao,Nanxia Xuan et al.
Kai Zhang et al.
Background: High-quality evidence for whether the use of renin-angiotensin-aldosterone system (RAAS) inhibitors worsens clinical outcomes for patients with coronavirus disease 2019 (COVID-19) is lacking. The present study...
An expanded definition of acute respiratory distress syndrome: Challenging the status quo [0.03%]
对急性呼吸窘迫综合征的扩大定义：挑战现状
Xueyan Yuan,Chun Pan,Jianfeng Xie et al.
Xueyan Yuan et al.
Although the Berlin definition of acute respiratory distress syndrome (ARDS), 2012 has been widely used in clinical practice, issues have occasionally been raised regarding various criteria since it was proposed. High-flow nasal oxygen (HFN...
Non-invasive ventilation for acute hypoxemic respiratory failure, including COVID-19 [0.03%]
急性低氧性呼吸衰竭（包括新冠肺炎）的无创通气治疗
Tommaso Rosà,Luca Salvatore Menga,Ambika Tejpal et al.
Tommaso Rosà et al.
Optimal initial non-invasive management of acute hypoxemic respiratory failure (AHRF), of both coronavirus disease 2019 (COVID-19) and non-COVID-19 etiologies, has been the subject of significant discussion. Avoidance of endotracheal intuba...
Early identification of acute respiratory distress syndrome in times of the COVID-19 pandemic [0.03%]
新冠肺炎疫情期间急性呼吸窘迫综合征的早期识别
Arnaud W Thille
Arnaud W Thille
Extracorporeal membrane oxygenation in COVID-19 associated acute respiratory distress syndrome: A narrative review [0.03%]
新冠肺炎相关急性呼吸窘迫综合征的体外膜肺氧合治疗：综述
Benjamin Assouline,Alain Combes,Matthieu Schmidt
Benjamin Assouline
Venovenous extracorporeal membrane oxygenation (VV-ECMO) is an established rescue therapy in the management of refractory acute respiratory distress syndrome (ARDS). Although ECMO played an important role in previous respiratory viral epide...
George Dimopoulos,Maria-Panagiota Almyroudi,Pavlos Myrianthefs et al.
George Dimopoulos et al.
Invasive Pulmonary Aspergillosis (IPA) has been recognized as a possible secondary infection complicating Coronavirus disease 2019 (COVID-19) and increasing mortality. The aim of this review was to report and summarize the available data in...
Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients [0.03%]
基于极端梯度提升算法的机器学习预测COVID-19患者入住ICU时5天后的SOFA评分变化值
Jonathan Montomoli,Luca Romeo,Sara Moccia et al.
Jonathan Montomoli et al.
Background: Accurate risk stratification of critically ill patients with coronavirus disease 2019 (COVID-19) is essential for optimizing resource allocation, delivering targeted interventions, and maximizing patient survi...
High-flow nasal cannula oxygen therapy in acute hypoxemic respiratory failure and COVID-19-related respiratory failure [0.03%]
急性低氧性呼吸衰竭和COVID-19相关呼吸衰竭的高流量鼻导管吸氧治疗
Jean-Pierre Frat,Laura Marchasson,François Arrivé et al.
Jean-Pierre Frat et al.
Although standard oxygen face masks are first-line therapy for patients with acute hypoxemic respiratory failure, high-flow nasal cannula oxygen therapy has gained major popularity in intensive care units. The physiological effects of high-...
Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19: A multicenter, randomized, double-blind, phase 1b trial [0.03%]
选择性RIPK1抑制剂SIR1-365治疗重症COVID-19住院患者的安全性和有效性：一项多中心、随机、双盲、Ⅰb期试验
Background: Receptor-interacting protein kinase 1 (RIPK1), a serine/threonine protein kinase, is mainly activated by pro-inflammatory cytokines and pathogens, including severe acute respiratory syndrome coronavirus 2 (SAR...