Deep Learning and Experimental Validation of BRCA1-Associated Protein-1 Missense Variant Pathogenicity in Uveal Melanoma [0.03%]
利用深度学习和实验验证BRCA1相关蛋白-1错义突变在脉络膜黑色素瘤中的致病性
Nikhil Davé,David J Taylor Gonzalez,Mak B Djulbegovic et al.
Nikhil Davé et al.
Objective: To benchmark the pathogenicity predictions of AlphaMissense, a deep learning model, against high-throughput functional scores from saturation genome editing (SGE) for all experimentally tested BRCA1-associated ...
Triglyceride-Glucose Indexes Are Predictive of Early and Severe Diabetic Retinal Microvascular Abnormalities: A Prospective Cohort Study [0.03%]
三酰甘油-葡萄糖指数可预测糖尿病视网膜微血管病变：一项前瞻性队列研究
Yu Wang,Bo Zang,Jiangyue Zhao et al.
Yu Wang et al.
Purpose: To evaluate the associations of the triglyceride-glucose (TyG) index and TyG-derived metrics with diabetic retinopathy (DR) subtypes, retinal lesions, and retinal vascular metrics in adults with type 2 diabetes (...
Marker-Free, Automated Eyelid Assessment in Thyroid Eye Disease Using Artificial Intelligence: A Multicenter Validation Study [0.03%]
基于人工智能的无标记自动算法评估甲状腺眼病患者睑裂大小：多中心验证研究
Jae Hoon Moon,Jongchan Kim,Joonhyeon Park et al.
Jae Hoon Moon et al.
Objective: To validate "Glandy LID," a novel marker-free, deep learning-based software designed for the automated assessment of eyelid morphology using intrinsic corneal diameter for calibration. ...
Randomized Clinical Trial of Diffusion Optics Technology Spectacle Lenses in a Chinese Population (CATHAY): 12-Month Results [0.03%]
中国人群(加华)眼镜透镜光学技术随机临床试验(CATHAY):一年结果
Zhi Chen,Xiao Yang,Longqian Liu et al.
Zhi Chen et al.
Objective: To evaluate 12-month myopia control efficacy of diffusion optics technology (DOT) spectacle lenses in a Chinese population (CATHAY study). Desi...
Cystoid Macular Edema in Retinitis Pigmentosa: Pathophysiologic Insight Using Swept-Source OCT and Angiography [0.03%]
应用扫频源光学相干断层扫描和血管造影探讨色素性视网膜炎的囊样视网膜上皮水肿的发病机制
Taariq K Mohammed,Kyle M Green,D Brice Critser et al.
Taariq K Mohammed et al.
Objective: Cystoid macular edema (CME) is relatively common in patients with retinitis pigmentosa (RP), but its pathophysiology is poorly understood. This study aims to provide insight into pathophysiologic mechanisms of ...
Predicting Visual Field Loss in Glaucoma Using OCT and Deep Learning: A Comparative Study of U-Net Variants [0.03%]
基于OCT和深度学习的青光眼视野缺损预测：U-Net变体比较研究
Kyoung Ohn,Jiwook Hwang,Jiwon Jung et al.
Kyoung Ohn et al.
Purpose: Glaucoma is a chronic eye disease that progressively damages the optic nerve, leading to irreversible visual field (VF) loss. OCT and VF tests are essential for monitoring structural and functional changes in gla...
Integrating Polygenic Risk and Ocular Phenotyping Reveals an Axial-Length-Dominant Mechanism in High and Extreme High Myopia [0.03%]
整合多基因风险和眼部表型特征揭示了高程度近视眼轴主导的发病机制
Jingwen Hui,Xuehao Cui,Qiuchen Zhao et al.
Jingwen Hui et al.
Objective: To integrate polygenic risk scoring with detailed ocular phenotyping to investigate severity-related genetic architecture in high myopia (HM) and extreme HM (EHM) in a clinically deeply phenotyped Chinese cohor...
Quantitative Markers of Neural Changes, Retinal Thickness, and Responses to Electrical Stimulation in Retinal Degeneration [0.03%]
视网膜退行性变中神经变化的量化标志物、视网膜厚度及电刺激反应研究
Hallur Reynisson,Maximillian Nguyen,Michael Kalloniatis et al.
Hallur Reynisson et al.
Purpose: Inherited retinal dystrophies demonstrate significant heterogeneity in the severity and distribution of photoreceptor loss. Current quantitative methodologies, however, do not account for this within-eye variatio...
Who Gets Panretinal Photocoagulation? National Patterns in Proliferative Diabetic Retinopathy Treatment [0.03%]
全视网膜激光光凝治疗的分布特征——美国增生型糖尿病性视网膜病变患者的治疗状况分析
Serina S Applebaum,Julia Fu,Mathieu Bakhoum et al.
Serina S Applebaum et al.
Purpose: To identify factors associated with receiving panretinal photocoagulation (PRP) among individuals treated in the first year after proliferative diabetic retinopathy (PDR) diagnosis. ...
Multiscale Attention Unet: An Innovative Approach for Segmentation of Optic Disc and Optic Cup in Early Detection of Retinopathy [0.03%]
一种新颖的视盘和视杯分割方法：多尺度注意力UNET在早期眼底病变筛查中的应用研究
Yichen Xiao,Qinghong Lin,Ziwei Xiang et al.
Yichen Xiao et al.
Objective: To develop an accurate optic disc (OD) and optic cup (OC) segmentation model for early glaucoma detection and differentiation from high myopia through precise cup-to-disc ratio (CDR) calculation. Timely interve...