Bridging the age gap: improving representation of older adults in clinical trials for type 2 diabetes and chronic kidney disease [0.03%]
跨越年龄差距：改善2型糖尿病和慢性肾病临床试验中老年人的代表性
Changyuan Yang,Hanneke Joosten,Lynne Chepulis et al.
Changyuan Yang et al.
Chronic kidney disease (CKD) is common among older adults, with more than a third of individuals older than 65 years having moderate to severe CKD globally. Management of CKD in older adults is often complex because of multiple comorbiditie...
Carmen Ardanuy,Jordi Càmara
Carmen Ardanuy
Long-term survival after invasive pneumococcal disease: a matched cohort study using electronic health records in England [0.03%]
基于英格兰电子健康记录的侵袭性肺炎链球菌病长期生存结局匹配队列研究
Anne Suffel,Fariyo Abdullahi,Eleanor Barry et al.
Anne Suffel et al.
Background: Invasive pneumococcal disease (IPD) is associated with increased long-term mortality, but it is unclear if this is explained by pre-existing comorbidities. We aimed to estimate the long-term survival following...
Philippa K Harris
Philippa K Harris
Cognitive recovery as a target in treatment-resistant late-life depression: progress made, challenges remain [0.03%]
难治性晚发抑郁症认知功能改善治疗的研究进展与挑战
Christoph Mueller,Beatriz Pozuelo Moyano
Christoph Mueller
Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial [0.03%]
难治性抑郁老人的药物治疗对认知功能影响的二次分析：英国OPTIMUM随机对照试验结果
Hanadi A Oughli,Nicholas J Ainsworth,Meryl A Butters et al.
Hanadi A Oughli et al.
Background: The cognitive effects of various antidepressant strategies for treatment-resistant depression in older adults are unclear. We aimed to evaluate acute cognitive changes associated with various pharmacotherapy t...
Randomized Controlled Trial
The lancet. Healthy longevity. 2025 Oct;6(10):100767. DOI:10.1016/j.lanhl.2025.100767 2025
Pain and suicide in ageing societies: closing a structural blind spot [0.03%]
老龄化社会中的疼痛与自杀：弥补一个结构性盲点
Nilson N Mendes Neto,Jessika M Mendes,Thiago Duarte et al.
Nilson N Mendes Neto et al.
Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis [0.03%]
基于DNA甲基化时钟测量的生物学年龄与衰弱的关系：系统评价和荟萃分析
Jian Hua Tay,Duarte Barros,Weilan Wang et al.
Jian Hua Tay et al.
Background: Frailty is an age-related condition characterised by multisystem physiological decline, which increases vulnerability to adverse outcomes. Biomarkers of ageing might identify individuals at risk and enable ear...
Disentangling the link between frailty and DNA methylation clock: new insights [0.03%]
表观遗传学钟与脆弱性关联性的研究进展
Sandrine Sourdet,Laurent Balardy
Sandrine Sourdet
The WHO Integrated Care for Older People programme: a key strategy for addressing ageing in sub-Saharan Africa [0.03%]
世界卫生组织老年整体护理项目：解决东非地区人口老龄化的关键策略
Maturin Tabue-Teguo,Marie-Josiane Ntsama-Essomba,Moustapha Drame et al.
Maturin Tabue-Teguo et al.