Activation of the envelope stress-responsive two-component system AmgRS compensates for depletion of the essential lipoprotein signal peptidase LspA in Pseudomonas aeruginosa [0.03%]
铜绿假单胞菌中激活包膜压力反应型双组分系统AmgRS可以补偿必不可少的脂蛋白信号肽酶LspA的减少
Davide Sposato,Giorgia Molesini,Christopher Riccardi et al.
Davide Sposato et al.
Bacterial lipoproteins play crucial roles in cell envelope biogenesis, signaling, transport, and virulence, making the enzymes responsible for their maturation attractive targets for antibacterial drug development. Among these, the type II ...
Fimbriae potentiate Aggregatibacter actinomycetemcomitans for periodontal disease [0.03%]
牙菌毛促进齿龈卟啉单胞杆菌的牙周病发展
Yanyan Fu,Qiqi Pan,Jan Maarten van Dijl
Yanyan Fu
Aggregatibacter actinomycetemcomitans is a major contributor to aggressive periodontitis and has been increasingly implicated in systemic conditions, such as rheumatoid arthritis and Alzheimer's disease. Among its diverse virulence mechanis...
Circadian rhythms regulate osteoclast recycling through gut microbiota-dependent Th17 cell expansion [0.03%]
肠道微生物群依赖的Th17细胞增殖通过昼夜节律调节破骨细胞更新换代
Shuo Ni,Weicong Fu,Lizong Zhang et al.
Shuo Ni et al.
The circadian clock coordinates diverse biological processes to maintain physiological function and homeostasis in mammals under the day-night light cycle. Disruption of circadian rhythms impairs immune and metabolic functions and increases...
Loss of cPLA2α function attenuates inflammation and epithelial thickening in a mouse model of Haemophilus influenzae-mediated COPD exacerbation [0.03%]
cPLA2α功能丧失减轻了溶血性流感嗜血杆菌介导的慢性阻塞性肺病急性加重小鼠模型中的炎症和上皮增厚现象
Brice Lagrange,Fatima Benmohamed,Alice Eon-Bertho et al.
Brice Lagrange et al.
Among the characteristics of chronic obstructive pulmonary diseases (COPD) especially emphysema are chronic airway inflammation and tissue destruction in response to the primary etiologic factor, cigarette smoking (CS). Importantly, COPD is...
The lncRNA GAS5-encoded micropeptide facilitates influenza virus replication through modulation of the Wnt/β-catenin signaling pathway [0.03%]
长非编码RNA GAS5 编码的微肽通过调节Wnt/β-连环蛋白信号通路促进流感病毒复制
Xinni Zhou,Xiaojuan Chi,Benqun Peng et al.
Xinni Zhou et al.
Long non-coding RNAs (lncRNAs) have been implicated in various cellular processes, including the regulation of gene expression and cellular response to viral infections. Herein, our RNA-seq analysis revealed a significant increase in the ex...
TseVF-TsiVF, a novel bacteriolytic effector-immunity pair of Vibrio fluvialis VflT6SS2, provides a fitness advantage in microbial competition [0.03%]
哈氏水产弧菌VflT6SS2新型溶菌效应蛋白-免疫蛋白对TseVF-TsiVF增强微生物竞争适应性研究
Yu Han,Yue Xiao,Yuanming Huang et al.
Yu Han et al.
Vibrio fluvialis (V. fluvialis) is a halophilic Gram-negative bacterium regarded as an emerging pathogen that can cause severe cholera-like diarrhea and various extraintestinal infections. Type VI secretion systems (T6SSs) are nano-weapons ...
Diversity and transmission processes of potentially pathogenic bacterial communities in the East Rongbuk Glaciers, Mt. Everest [0.03%]
珠穆朗玛峰东绒布冰川病原细菌多样性和传播过程研究
Tong Ma,Yeteng Xu,Xinyue Wang et al.
Tong Ma et al.
Glacier retreat driven by global warming is releasing previously sequestered microbial communities, including potential human pathogens, into downstream environments. However, the diversity, ecological assembly mechanisms, and dispersal pro...
A longitudinal profiling of microbiome of diabetic foot ulcers shows functional role of microbial communities in wound worsening and chronicity [0.03%]
糖尿病足溃疡微生物组纵向特征分析揭示了微生物群在伤口恶化和慢性创面形成中的作用
Chandni Sachdeva,Seetharam Shiva Prasad,Kallya Rajgopal Shenoy et al.
Chandni Sachdeva et al.
Microbial communities in infected diabetic foot ulcers (DFUs) play a critical role in wound morbidity and healing outcomes. While cross-sectional studies that profile the microbial communities using culture-independent approaches are availa...
Vegetation composition shapes denitrifier community structure and enhances nitrogen removal in estuarine wetlands: evidence from Reed-Willow Mix promoting nirK-dominated guilds [0.03%]
植被组成塑造反硝化菌群落结构并提升河口湿地氮清除能力：芦苇-灌木湿生柳混种促进以nirK型功能菌为主的菌群形成并增强脱氮效能
Shengni Tian,Dan Huang,Guokai Yuan et al.
Shengni Tian et al.
Estuarine wetlands are critical biogeochemical hotspots where vegetation and soil properties jointly regulate microbial processes such as denitrification. This study investigated soil physicochemical properties and denitrifying bacterial co...
Omics-based dissection of alternative splicing and the regulatory architecture in fungal genomes [0.03%]
基于组学的对真菌基因组中选择性拼接及调控体系的解析
João Neves-da-Rocha,Marcos E R Lopes,Maria J Santos-Saboya et al.
João Neves-da-Rocha et al.
Assigning mechanistic and functional associations to most of the widespread splicing diversity in fungi has been one of the continuous and most intriguing challenges in the field of molecular mycology. Ongoing advances in sequencing technol...