Characterization of a novel Mycobacterium tuberculosis serine protease Rv1815 in regulating bacterial metabolism and macrophage intracellular survival [0.03%]
表征一种新的结核杆菌丝氨酸蛋白酶Rv1815在调节细菌代谢和巨噬细胞胞内存活中的作用
Qishun Feng,Qiao Lin,Zhang Xia et al.
Qishun Feng et al.
The serine proteases of Mycobacterium tuberculosis (Mtb) are critical contributors to bacterial invasion and pathogenesis. In this study, we characterized the role of a novel serine protease Rv1815 in Mtb. Our findings indicate that Rv1815 ...
One-year multicenter surveillance of Fosfomycin resistance Enterobacterales: the rise of FosA3-producing P. mirabilis [0.03%]
一年期多中心监视：产生FosA3的阴沟肠杆菌属引起的fosfomycin抗性监测结果
Katerina Chudejova,Vittoria Mattioni Marchetti,Vita Zaccaria et al.
Katerina Chudejova et al.
The global rise of antimicrobial resistance has renewed interest in fosfomycin (FOS), an old antibiotic with activity against multidrug-resistant Enterobacterales. However, resistance to FOS is increasing, driven by impaired drug uptake, ta...
A novel self-transmissible mega plasmid from extensively drug-resistant Klebsiella oxytoca carries multiple antimicrobial resistance genes and acts as a resistance reservoir [0.03%]
一新型可自我传播的巨型质粒可携带多重耐药基因并作为碳氢化合物的储存库存在于多种药物耐药性的克莱西ellas oxytoca菌株中
Yu Wang,Sylvia A Sapula,Bradley J Hart et al.
Yu Wang et al.
Klebsiella oxytoca is an opportunistic pathogen linked to hospital-acquired infections, with extensively drug-resistant (XDR) strains posing serious treatment challenges. Here, an XDR K. oxytoca 611 isolated from hospital wastewater was fou...
Explainable AI-SERS approach for highly accurate discrimination of Escherichia coli pathotypes and Shigella species [0.03%]
基于可解释AI-SERS的方法准确区分大肠杆菌致病型和志贺菌物种
Jun-Hyeok Ham,Yu-Jin Jeon,Suji Lee et al.
Jun-Hyeok Ham et al.
Pathogenic Escherichia coli and Shigella species cause severe diarrheal diseases with high mortality but remain difficult to distinguish using conventional methods due to their close genetic and proteomic relatedness. To address this challe...
D-serine metabolism enhances Escherichia coli fitness in the gut and could contribute to Enterobacteriaceae expansion in Crohn's disease patients [0.03%]
D-丝氨酸代谢可增强大肠埃希氏菌在肠道中的适应度并可能促进克罗恩病患者的肠杆菌科细菌的扩增
Maria Ines Moreira de Gouveia,Amelie Blanchot,Annie Garrivier et al.
Maria Ines Moreira de Gouveia et al.
Gut dysbiosis associated with several intestinal and extra-intestinal diseases is frequently characterized by an expansion of Enterobacteriaceae, which typically represent only a few percent of the total gut microbiota in healthy individual...
Aridity gradient overrides degradation in shaping the topsoil microbiome of the Tianshan wild fruit forest [0.03%]
干旱梯度决定了天山野果林土壤微生物群落组装overwrite_degradation_shape_soil_microbiomes_tianshan_wild_fruit_forest
Yong-Hong Liu,Jian-Rong Huang,Ye Tao et al.
Yong-Hong Liu et al.
The Tianshan wild fruit forest, a critical relict ecosystem and biodiversity hotspot, is experiencing severe degradation, a process widely assumed to be the primary driver of negative shifts in soil microbial communities. However, in arid r...
MrkA enhances the virulence phenotype of carbapenem-resistant Klebsiella pneumoniae both in vitro and in vivo [0.03%]
MRKA通过增强碳青霉烯耐药肺炎克雷伯菌的毒力表型而促进细菌致病性
Xiaoyu Zhao,Qingqing Du,Yunuo Xiang et al.
Xiaoyu Zhao et al.
Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a severe threat to public health, but the factors underlying its virulence are not fully understood. This study identified a novel and critical role for the type 3 fimbrial component M...
Therapeutic challenges and emerging strategies against carbapenem-resistant Acinetobacter baumannii [0.03%]
碳青霉烯耐药阿氏不动杆菌的治疗挑战及新策略
Chunhong Yang,Jing Li,Xiao Luo et al.
Chunhong Yang et al.
Carbapenem-resistant Acinetobacter baumannii (CRAB) remains a formidable clinical challenge, driven by limited therapeutic options and multifaceted resistance mechanisms. While current polypharmacy regimens require evidence-based refinement...
How are kefir microbial communities and product characteristics maintained in industrial production? [0.03%]
工业生产中如何保持开菲尔乳杆菌的微生物群和产品特性？
Ji Qingyang,Li Qiming,Gu Ruixia
Ji Qingyang
Kefir, a millennia-old symbiotic fermented dairy product, has emerged as a focal point of research in the global functional foods sector owing to its distinctive organoleptic properties and extensive health-promoting effects. Kefir grains, ...
Phage P100 resistance in clinical and foodborne Listeria monocytogenes isolates is associated with adsorption-inhibiting mutations and fitness trade-offs [0.03%]
临床和食源性李斯特菌中噬菌体P100抗性的吸附抑制突变及相关适应性权衡关系
Christoph Brieske,Frank Hille,Erik Brinks et al.
Christoph Brieske et al.
Listeria monocytogenes is a common bacterial pathogen causing listeriosis. Phage-based products are increasingly used in food safety, but their use raises concerns about the emergence of phage-resistant bacteria. The broad-host-range phage ...