Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo [0.03%]
一种用于[1-13C]丙酮酸的简便超极化化学分子成像和在体代谢追踪方法
Keilian MacCulloch,Austin Browning,David O Guarin Bedoya et al.
Keilian MacCulloch et al.
Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to attain high levels of nuclear spin hyperpolarization, which ca...
X-nuclear MRS and MRI on a standard clinical proton-only MRI scanner [0.03%]
一种在临床单氢核磁共振成像仪上实现X核磁共振和磁共振波谱的新方法
Yi-Fen Yen,Atsushi M Takahashi,Jerome L Ackerman
Yi-Fen Yen
In light of the growing interest in-vivo deuterium metabolic imaging, hyperpolarized 13C, 15N, 3He, and 129Xe imaging, as well as 31P spectroscopy and imaging in large animals on clinical MR scanners, we demonstrate the use of a (radio)freq...
Inductively coupled, transmit-receive coils for proton MRI and X-nucleus MRI/MRS in small animals [0.03%]
小型动物体内氢质子MRI及其它原子核MRI/MRS的发射/接收线圈的互感耦合技术
Atsushi M Takahashi,Jitendra Sharma,David O Guarin et al.
Atsushi M Takahashi et al.
We report several inductively coupled RF coil designs that are very easy to construct, produce high signal-to-noise ratio (SNR) and high spatial resolution while accommodating life support, anesthesia and monitoring in small animals. Induct...
Evaluation of multi-channel phase reconstruction methods for quantitative susceptibility mapping on postmortem human brain [0.03%]
多通道相位重建方法在死后人脑定量磁敏感图中的评价研究
Fábio Seiji Otsuka,Maria Concepcion Garcia Otaduy,José Henrique Monteiro Azevedo et al.
Fábio Seiji Otsuka et al.
Quantitative Susceptibility Mapping (QSM) is an established Magnetic Resonance Imaging (MRI) technique with high potential in brain iron studies associated to several neurodegenerative diseases. Unlike other MRI techniques, QSM relies on ph...
G A Nagana Gowda,Vadim Pascua,Daniel Raftery
G A Nagana Gowda
Human blood is the most widely used biospecimen in the clinic and the metabolomics field. While both mass spectrometry and NMR spectroscopy are the two premier analytical platforms in the metabolomics field, NMR exhibits several unsurpassed...
Nesreen Elathram,Bryce E Ackermann,Galia T Debelouchina
Nesreen Elathram
Chromatin is a DNA-protein polymer that represents the functional form of the genome. The main building block of chromatin is the nucleosome, a structure that contains 147 base pairs of DNA and two copies each of the histone proteins H2A, H...
Elucidating the mechanisms underlying protein conformational switching using NMR spectroscopy [0.03%]
基于核磁共振技术阐明蛋白质构象变化的机制研究
Shefali Jain,Ashok Sekhar
Shefali Jain
How proteins switch between various ligand-free and ligand-bound structures has been a key biophysical question ever since the postulation of the Monod-Wyman-Changeux and Koshland-Nemethy-Filmer models over six decades ago. The ability of N...
Interfacing Liquid State Hyperpolarization Methods with NMR Instrumentation [0.03%]
液态超极化方法与核磁共振仪器接口技术
Pierce Pham,Ratnamala Mandal,Chang Qi et al.
Pierce Pham et al.
Advances in liquid state hyperpolarization methods have enabled new applications of high-resolution NMR spectroscopy. Utilizing strong signal enhancements from hyperpolarization allows performing NMR spectroscopy at low concentration, or wi...
Evan T Clark,Elanor E Sievers,Galia T Debelouchina
Evan T Clark
Among structural biology techniques, NMR spectroscopy offers unique capabilities that enable the atomic resolution studies of dynamic and heterogeneous biological systems under physiological and native conditions. Complex biological systems...
New insights from broadband simulations into small overmoded smooth and corrugated terahertz waveguides and transitions for NMR-DNP [0.03%]
宽带仿真在小过模式光滑及corrugated太赫兹波导及用于NMR-DNP的过渡中的新见解
F David Doty,Glenn N Doty,John P Staab et al.
F David Doty et al.
The primary impetus for the work reported in this paper is to develop efficient overmoded waveguides (OMWGs) that employ broadband downtaper transitions that would be compatible with the severe space constraints in high-field NB magnets. Fu...