An Experiment on Ab Initio Discovery of Biological Knowledge from scRNA-Seq Data Using Machine Learning [0.03%]
基于单细胞 RNA 测序数据的从头式生物知识机器学习发现实验
Najeebullah Shah,Jiaqi Li,Fanhong Li et al.
Najeebullah Shah et al.
Expectations of machine learning (ML) are high for discovering new patterns in high-throughput biological data, but most such practices are accustomed to relying on existing knowledge conditions to design experiments. Investigations of the ...
Identification of Intrinsic Drug Resistance and Its Biomarkers in High-Throughput Pharmacogenomic and CRISPR Screens [0.03%]
高通量药物基因组学和CRISPR筛选中内在耐药性及其生物标志物的识别
Iñigo Ayestaran,Ana Galhoz,Elmar Spiegel et al.
Iñigo Ayestaran et al.
High-throughput drug screens in cancer cell lines test compounds at low concentrations, thereby enabling the identification of drug-sensitivity biomarkers, while resistance biomarkers remain underexplored. Dissecting meaningful drug respons...
Hylke Koers,Daniel Bangert,Emilie Hermans et al.
Hylke Koers et al.
The development and growing adoption of the FAIR data principles and associated standards as a part of research policies and practices place novel demands on research data services. This article highlights common challenges and priorities a...
Integrated Value of Influence: An Integrative Method for the Identification of the Most Influential Nodes within Networks [0.03%]
综合影响力评价：一种识别网络中最具影响力节点的整合方法
Adrian Salavaty,Mirana Ramialison,Peter D Currie
Adrian Salavaty
Biological systems are composed of highly complex networks, and decoding the functional significance of individual network components is critical for understanding healthy and diseased states. Several algorithms have been designed to identi...
Human Data Science [0.03%]
人脑科学
D L Oberski
D L Oberski
Most data science is about people, and opinions on the value of human data differ. The author offers a synthesis of overly optimistic and overly pessimistic views of human data science: it should become a science, with errors systematically...
Bridging Domain and Data [0.03%]
跨越领域和数据
Anne E Carpenter
Anne E Carpenter
Dr. Anne Carpenter addresses her career path from cell biology toward computation. Why would a researcher move outside their comfort zone into a different field, from a domain into data science? What is the best way to bridge domain and dat...
Data for Politics: Creating an International Research Infrastructure Measuring Democracy [0.03%]
政治数据：创建一个度量民主的国际研究基础设施
Staffan I Lindberg,Juraj Medzihorsky
Staffan I Lindberg
Questions such as how democratic a country is, how free are its media, or how independent is its judiciary are highly important to researchers and decision makers. We describe a research infrastructure that produces the world's largest data...
When Autonomous Systems Meet Accuracy and Transferability through AI: A Survey [0.03%]
当自主系统通过AI邂逅准确性和泛化性：综述
Chongzhen Zhang,Jianrui Wang,Gary G Yen et al.
Chongzhen Zhang et al.
With widespread applications of artificial intelligence (AI), the capabilities of the perception, understanding, decision-making, and control for autonomous systems have improved significantly in recent years. When autonomous systems consid...
Rapid Trust Calibration through Interpretable and Uncertainty-Aware AI [0.03%]
通过可解释性和不确定性 Aware AI 进行快速信任校准
Richard Tomsett,Alun Preece,Dave Braines et al.
Richard Tomsett et al.
Artificial intelligence (AI) systems hold great promise as decision-support tools, but we must be able to identify and understand their inevitable mistakes if they are to fulfill this potential. This is particularly true in domains where th...
Nicholas Rougeux
Nicholas Rougeux
An introduction to the work of web designer and artist Nick Rougeux, who created the cover art for this edition of Patterns. Here he explains his method for visualizing music scores and highlights the importance of exploring data through im...