Noise regularization removes correlation artifacts in single-cell RNA-seq data preprocessing [0.03%]
噪声正则化去除单细胞RNA测序数据预处理中的相关性伪迹现象
Ruoyu Zhang,Gurinder S Atwal,Wei Keat Lim
Ruoyu Zhang
With the rapid advancement of single-cell RNA-sequencing (scRNA-seq) technology, many data-preprocessing methods have been proposed to address numerous systematic errors and technical variabilities inherent in this technology. While these m...
Sara Lafia,Werner Kuhn,Kelly Caylor et al.
Sara Lafia et al.
The institutional review of interdisciplinary bodies of research lacks methods to systematically produce higher-level abstractions. Abstraction methods, like the "distant reading" of corpora, are increasingly important for knowledge discove...
The risk of re-identification remains high even in country-scale location datasets [0.03%]
即使在国家规模的位置数据集中，重新识别的风险仍然很高
Ali Farzanehfar,Florimond Houssiau,Yves-Alexandre de Montjoye
Ali Farzanehfar
Although anonymous data are not considered personal data, recent research has shown how individuals can often be re-identified. Scholars have argued that previous findings apply only to small-scale datasets and that privacy is preserved in ...
Andreas Kopf,Manfred Claassen
Andreas Kopf
Current data generation capabilities in the life sciences render scientists in an apparently contradicting situation. While it is possible to simultaneously measure an ever-increasing number of systems parameters, the resulting data are bec...
Animal behavior and animal personality from a non-human perspective: Getting help from the machine [0.03%]
从非人类视角看动物行为和动物性格：借助机器的帮助
Oren Forkosh
Oren Forkosh
We can now track the position of every fly's leg or immerse a tiny fish inside a virtual world by monitoring its gaze in real time. Yet capturing animals' posture or gaze is not like understanding their behavior. Instead, behaviors are stil...
VERSO: A comprehensive framework for the inference of robust phylogenies and the quantification of intra-host genomic diversity of viral samples [0.03%]
VERSO：推断稳健的系统发育树和量化病毒样本体内基因组多样性的全面框架
Daniele Ramazzotti,Fabrizio Angaroni,Davide Maspero et al.
Daniele Ramazzotti et al.
We introduce VERSO, a two-step framework for the characterization of viral evolution from sequencing data of viral genomes, which is an improvement on phylogenomic approaches for consensus sequences. VERSO exploits an efficient algorithmic ...
Martin-Immanuel Bittner
Martin-Immanuel Bittner
A continuous cycle of hypotheses, data generation, and revision of theories drives biomedical research forward. Yet, the widely reported lack of reproducibility requires us to revise the very notion of what constitutes relevant scientific d...
Data hygiene factors [0.03%]
数据清理因素
Christopher Gutteridge
Christopher Gutteridge
The goal of making your data available is that other people can reuse it. A number of factors can prevent anybody from ever exploiting your data. This article reviews some of these factors and suggests some low effort ways you can increase ...
Graham Lee,Sebastian Bacon,Ian Bush et al.
Graham Lee et al.
The importance of software to modern research is well understood, as is the way in which software developed for research can support or undermine important research principles of findability, accessibility, interoperability, and reusability...
Abeba Birhane
Abeba Birhane
It has become trivial to point out that algorithmic systems increasingly pervade the social sphere. Improved efficiency-the hallmark of these systems-drives their mass integration into day-to-day life. However, as a robust body of research ...