Hypercalcemia as a Rebound Phenomenon of LOXO-292 Efficacy in Medullary Thyroid Cancer [0.03%]
洛索立宾疗效导致的甲状腺髓样癌血钙升高反跳现象
Waleed Kian,Dina Levitas,Wafeek Alguayn et al.
Waleed Kian et al.
Edward B Garon,James Chih-Hsin Yang,Steven M Dubinett
Edward B Garon
Introduction: Chronic inflammation is associated with an increased risk of several diseases, including cancer. A complex tumor microenvironment created and maintained by a range of cell types promotes tumor growth, angiog...
Tolerability of Coronavirus Disease 2019 Vaccines, BNT162b2 and mRNA-1273, in Patients With Thymic Epithelial Tumors [0.03%]
新冠疫苗BNT162b2和mRNA-1273在胸腺上皮肿瘤患者中的耐受性研究
Madison Ballman,Shannon Swift,Cristina Mullenix et al.
Madison Ballman et al.
Introduction: Defects in immunologic self-tolerance result in an increased risk for development of paraneoplastic autoimmune diseases (ADs) and immune-mediated toxicity in response to immune stimulation in individuals wit...
EGFR-A763_Y764insFQEA Is a Unique Exon 20 Insertion Mutation That Displays Sensitivity to Approved and In-Development Lung Cancer EGFR Tyrosine Kinase Inhibitors [0.03%]
独特的EGFR A763_Y764insFQEA exon20插入突变体对已批准的和在开发中的肺癌EGFR酪氨酸激酶抑制剂药物敏感
Pedro E N S Vasconcelos,Carol Gergis,Hollis Viray et al.
Pedro E N S Vasconcelos et al.
Introduction: The EGFR-A763_Y764insFQEA is a unique exon 20 insertion mutation (~5% to 6% of exon 20 insertions), which, at the structural and enzyme kinetic level, more closely resembles EGFR tyrosine kinase inhibitor (T...
Preclinical characterization of mobocertinib highlights the putative therapeutic window of this novel EGFR inhibitor to EGFR exon 20 insertion mutations [0.03%]
莫博赛替尼的临床前研究特征表明了该新型表皮生长因子受体插入突变抑制剂的作用治疗窗口
Pedro E N S Vasconcelos,Ikei S Kobayashi,Susumu S Kobayashi et al.
Pedro E N S Vasconcelos et al.
Background: Epidermal growth factor receptor (EGFR) exon 20 insertion mutations account for 10% of all EGFR mutations and are mostly insensitive to approved EGFR-tyrosine kinase inhibitors (EGFR-TKIs). Novel EGFR-TKIs hav...
Ultrarapid EGFR Mutation Screening Followed by Comprehensive Next-Generation Sequencing: A Feasible, Informative Approach for Lung Carcinoma Cytology Specimens With a High Success Rate [0.03%]
可行的、具有高成功率的肺癌细胞学标本的超快速EGFR突变筛查及全面一代测序检测方法
Maria E Arcila,Soo-Ryum Yang,Amir Momeni et al.
Maria E Arcila et al.
Introduction: For patients with advanced NSCLC, cytologic samples may be the only diagnostic specimen available for molecular profiling. Although both rapid and comprehensive assessment are essential in this setting, an i...
The Feasibility and Safety of Routine Thoracic Surgeries in the Low-Risk Areas During the Coronavirus Disease 2019 Pandemic [0.03%]
新型冠状病毒肺炎疫情期间低风险地区常规胸部手术的可行性和安全性
Yiyang Wang,Yonghui Zhang,Feichao Bao et al.
Yiyang Wang et al.
Coronavirus disease 2019 (COVID-19) has been under good control, and work resumption has been gradually carried out in most parts of the People's Republic of China including Shanghai after March 2020. However, intense focus and resources ha...
A Systematic Review and Meta-Analysis of Clinical Characteristics and Outcomes in Patients With Lung Cancer with Coronavirus Disease 2019 [0.03%]
新型冠状病毒肺炎肺癌患者临床特征和预后的系统评价和 meta 分析
Monica Peravali,Ishani Joshi,Jaeil Ahn et al.
Monica Peravali et al.
Cancer is considered to be an independent risk factor for severe illness and higher mortality in patients with coronavirus disease 2019 (COVID-19). These adverse outcomes have been suspected to be more severe in patients with lung cancer. T...
A Cured Coronavirus Disease 2019 Case of an 86-Year-Old With 13 Chronic Diseases: A Case Report [0.03%]
一例86岁合并13种慢性疾病的新冠肺炎治愈病例报告
Yanhong Tu,Ji Fang,Menghui Yin et al.
Yanhong Tu et al.
Pamela L Karas,Nicole M Rankin,Emily Stone
Pamela L Karas
Health professionals participating in multidisciplinary team (MDT) cancer meetings may not be aware of their medicolegal obligations. This commentary aims to identify medicolegal issues concerning multidisciplinary cancer care and provides ...