Brief Report of Anti-Programmed Cell Death Protein-1 in Human Immunodeficiency Virus Setting: Relevant and Breaking Results in First-Line NSCLC Therapy [0.03%]
抗程序性细胞死亡蛋白-1在人类免疫缺陷病毒环境中的简要报告：一线NSCLC治疗的相关性和突破性结果
Lise Bertin,Anthony Canellas,Baptiste Abbar et al.
Lise Bertin et al.
In the recent past, we observed an increased risk of cancer in the population with human immunodeficiency virus (HIV) owing to the development of antiretroviral therapies that decreased mortality caused by HIV-specific infections. This part...
Efficacy of Targeted Inhibitors in Metastatic Lung Squamous Cell Carcinoma With EGFR or ALK Alterations [0.03%]
EGFR或ALK基因改变的转移性肺鳞状细胞癌中靶向抑制剂的有效性
Whitney E Lewis,Lingzhi Hong,Frank E Mott et al.
Whitney E Lewis et al.
Introduction: The efficacy of targeted therapies in oncogene-driven lung adenocarcinomas (LUADs) has been well established; however, the benefit for EGFR-mutant or ALK-rearranged lung squamous cell carcinomas (LUSCs) is l...
Technical Feasibility and Safety of Repeated Computed Tomography-Guided Transthoracic Intratumoral Injection of Gene-Modified Cellular Immunotherapy in Metastatic NSCLC [0.03%]
重复CT引导下经胸肿瘤内基因修饰的细胞免疫治疗在转移性非小细胞肺癌中的技术可行性和安全性
Puja Shahrouki,Jay M Lee,Jonathan Barclay et al.
Puja Shahrouki et al.
Introduction: To assess the technical feasibility and safety of repeated percutaneous computed tomography (CT)-guided transthoracic biopsies and intratumoral injections of gene-modified dendritic cells in metastatic NSCLC...
Hookah Smoke Mediates Cancer-Associated Epigenomic and Transcriptomic Signatures in Human Respiratory Epithelial Cells [0.03%]
水烟雾介导人类呼吸道上皮细胞的癌症相关表观基因组和转录组特征
Yin Xiong,Sichuan Xi,Sudheer Kumar Gara et al.
Yin Xiong et al.
Introduction: Although communal smoking of hookah by means of water pipes is perceived to be a safe alternative to cigarette smoking, the effects of hookah smoke in respiratory epithelia have not been well characterized. ...
Severe Psychiatric Symptoms in a Patient With EGFR Exon-20 Insertion Mutation Receiving Mobocertinib: A Case Report [0.03%]
接受Mobocertinib治疗的EGFR exon-20插入突变患者的严重精神症状一例报告
Josette Kamel,Natalie Meeder,Sandra Cuellar et al.
Josette Kamel et al.
Tyrosine kinase inhibitor therapy is an established standard of care for patients with NSCLC with EGFR mutations, but a worse prognosis has been observed in patients with specific EGFR exon-20 insertion mutations. Mobocertinib (TAK-788) is ...
MET Amplification and Efficacy of Nivolumab in Patients With NSCLC [0.03%]
MET扩增与NSCLC患者nivolumab疗效的关系
Katsuhiro Yoshimura,Yusuke Inoue,Naoki Inui et al.
Katsuhiro Yoshimura et al.
Introduction: MET amplification is an important genetic alteration in NSCLC. Unlike in patients with EGFR and ALK alterations, the efficacy of immune checkpoint inhibitors in patients with MET-amplified NSCLC remains unkn...
Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report [0.03%]
具有EWSR1-ATF1融合基因的恶性腹膜间皮瘤一例报告
Helen Ke,Anthony J Gill,Catriona McKenzie et al.
Helen Ke et al.
Malignant mesothelioma with EWSR1-ATF1 fusion is a rare malignancy described in young adults without asbestos exposure. To the best of our knowledge, outcomes to local and systemic therapies for this subtype of malignant mesothelioma have n...
Conversion Surgery for Advanced Thoracic SMARCA4-Deficient Undifferentiated Tumor With Atezolizumab in Combination With Bevacizumab, Paclitaxel, and Carboplatin Treatment: A Case Report [0.03%]
阿特朱单抗联合贝伐珠单抗、紫杉醇和卡铂治疗晚期胸腔SMARCA4缺乏未分化肿瘤转化手术一例报告
Kei Kunimasa,Jiro Okami,Satoshi Takenaka et al.
Kei Kunimasa et al.
A SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a rapidly progressing subtype of lung cancer with a poor prognosis and causes early postoperative recurrence among operable patients. In this study, we present a case of SMARCA4-UT ...
Abemaciclib in Combination With Pembrolizumab for Stage IV KRAS-Mutant or Squamous NSCLC: A Phase 1b Study [0.03%]
阿贝西利联合派姆单抗治疗IV期KRAS突变或鳞状NSCLC：一项Ib期研究
Jean-Louis Pujol,Johan Vansteenkiste,Luis Paz-Ares Rodríguez et al.
Jean-Louis Pujol et al.
Introduction: Abemaciclib is an oral, selective small-molecule CDK 4 and 6 inhibitor. In preclinical models, abemaciclib synergized with programmed cell death protein-1 blockade to enhance antitumor efficacy. Here, we rep...
CADM1 and SPC25 Gene Mutations in Lung Cancer Patients With Idiopathic Pulmonary Fibrosis [0.03%]
合并特发性肺纤维化的肺癌患者中CADM1和SPC25基因突变分析
Aya Fukuizumi,Rintaro Noro,Masahiro Seike et al.
Aya Fukuizumi et al.
Introduction: To investigate the genomic profiles of patients with lung cancer with idiopathic pulmonary fibrosis (IPF-LC), mechanism of carcinogenesis, and potential therapeutic targets. ...