Therapeutic effects of TP5, a Cdk5/p25 inhibitor, in in vitro and in vivo models of Parkinson's disease [0.03%]
TP5的治疗作用及其在帕金森病的体内外模型中的抑制Cdk5/p25的作用
Judith Tran,Shane K B Taylor,Anika Gupta et al.
Judith Tran et al.
Parkinson's Disease (PD) is a chronic progressive neurodegenerative disease. Current treatments for PD are symptomatic and only increase striatal dopamine levels. Proactive neuroprotective approaches that slow the progression of PD and main...
Decreased resting perfusion in precuneus and posterior cingulate cortex predicts tinnitus severity [0.03%]
静息态下楔前叶和后扣带回皮质灌注降低预示耳鸣严重程度
Benjamin J Zimmerman,Sara A Schmidt,Rafay A Khan et al.
Benjamin J Zimmerman et al.
Functional magnetic resonance imaging has been increasingly used to understand the mechanisms involved in subjective tinnitus; however, researchers have struggled to reach a consensus about a primary mechanistic model to explain tinnitus. W...
Auditory detection is modulated by theta phase of silent lip movements [0.03%]
无声唇读的theta频段脑电调制了听觉检测反应
Emmanuel Biau,Danying Wang,Hyojin Park et al.
Emmanuel Biau et al.
Audiovisual speech perception relies, among other things, on our expertise to map a speaker's lip movements with speech sounds. This multimodal matching is facilitated by salient syllable features that align lip movements and acoustic envel...
S C Barnett,L C Parr-Brownlie,B A L Perry et al.
S C Barnett et al.
A hippocampal-diencephalic-cortical network supports memory function. The anterior thalamic nuclei (ATN) form a key anatomical hub within this system. Consistent with this, injury to the mammillary body-ATN axis is associated with examples ...
Current Research in Neurobiology, an experimental platform for innovation [0.03%]
神经生物学最新研究——创新的实验平台
Christopher I Petkov,Abhishek Banerjee,Yogita Chudasama et al.
Christopher I Petkov et al.
Welcome to Current Research in Neurobiology (CRNEUR), the gold open access, sibling journal to Current Opinion in Neurobiology, a journal for timely original research in neuroscience. At its very core, CRNEUR is a journal for creativity and...
Dan Luo,Kongyan Li,HyunJung An et al.
Dan Luo et al.
Continuous acoustic streams, such as speech signals, can be chunked into segments containing reoccurring patterns (e.g., words). Noninvasive recordings of neural activity in humans suggest that chunking is underpinned by low-frequency corti...
Regulation of neuronal excitability by reactive oxygen species and calcium signaling: Insights into brain aging [0.03%]
活性氧和钙信号调控神经元兴奋性及其在脑衰老中的作用机制初探
Rachel L Doser,Frederic J Hoerndli
Rachel L Doser
Altered cognition and inefficient learning and memory are hallmarks of brain aging resulting from many small changes in the structure and function of neurons. One such change is a decrease in excitatory synaptic transmission mediated by glu...
Tactile information from the vibrissal system modulates hippocampal functioning [0.03%]
触须系统的感觉信息调节海马功能
Nereida Ibarra-Castañeda,Norma A Moy-Lopez,Óscar González-Pérez
Nereida Ibarra-Castañeda
Most mammals have sensory tactile hairs, also known as whiskers or vibrissae. Traditionally, whiskers are associated with diverse survival skills, including tactile discrimination, distance assessment, food acquisition, gap crossing, and so...
The molecular neurobiology and neuropathology of opioid use disorder [0.03%]
阿片类物质使用障碍的分子神经生物学和神经病理学
Christopher A Blackwood,Jean Lud Cadet
Christopher A Blackwood
The number of people diagnosed with opioid use disorder has skyrocketed as a consequence of the opioid epidemic and the increased prescribing of opioid drugs for chronic pain relief. Opioid use disorder is characterized by loss of control o...
Early life sleep disruption alters glutamate and dendritic spines in prefrontal cortex and impairs cognitive flexibility in prairie voles [0.03%]
早期睡眠紊乱会破坏草原田鼠前额叶皮层的谷氨酸和树突棘并损害其认知灵活性
Carolyn E Jones,Alex Q Chau,Randall J Olson et al.
Carolyn E Jones et al.
Early life experiences are crucial for proper organization of excitatory synapses within the brain, with outsized effects on late-maturing, experience-dependent regions such as the medial prefrontal cortex (mPFC). Previous work in our lab s...