Precise CRISPR-Cas9-mediated mutation of a membrane trafficking domain in the Drosophila vesicular monoamine transporter gene [0.03%]
在果蝇单胺转运体基因中精确定位的CRISPR-Cas9介导的突变
James D Asuncion,Aditya Eamani,Ethan W Rohrbach et al.
James D Asuncion et al.
Monoamine neurotransmitters such as noradrenalin are released from both synaptic vesicles (SVs) and large dense-core vesicles (LDCVs), the latter mediating extrasynaptic signaling. The contribution of synaptic versus extrasynaptic signaling...
Zara Arain,Stamatina Iliodromiti,Gregory Slabaugh et al.
Zara Arain et al.
Machine learning technologies and translation of artificial intelligence tools to enhance the patient experience are changing obstetric and maternity care. An increasing number of predictive tools have been developed with data sourced from ...
Endocardial role in arrhythmias induced by acute ventricular stretch and the involvement of Purkinje fibres, in isolated rat hearts [0.03%]
急性心室扩张诱导的阵发性心动过速及肺肌纤维在孤立心脏中的作用
Miriam Hurley,Sarbjot Kaur,Richard Walton et al.
Miriam Hurley et al.
Purkinje fibres (PFs) play an important role in some ventricular arrhythmias and acute ventricular stretch can evoke mechanically-induced arrhythmias. We tested whether PFs and specifically TRPM4 channels, play a role in these mechanically-...
Physiological levels of cardiolipin acutely affect mitochondrial respiration in vascular smooth muscle cells [0.03%]
心磷脂的生理水平急性影响血管平滑肌细胞中的线粒体呼吸作用
Deema Galambo,Andreas Bergdahl
Deema Galambo
Cardiolipin (CL) is a phospholipid molecule found in the inner mitochondrial membrane, where it normally associates with and activates the respiratory complexes. Following myocardial infarction, CL gets released from necrotic cells, consequ...
L-Arginine supplementation enhanced expression of glucose transporter (GLUT 1) in sickle cell anaemia subjects in the steady state [0.03%]
L-精氨酸补充剂提高了稳态下镰状细胞贫血受试者葡萄糖转运蛋白(GLUT 1)的表达量
W A Saka,C N Anigbogu,M O Kehinde et al.
W A Saka et al.
L-Arginine may have therapeutic value in the management of sickle cell disease and diabetes mellitus. There is very little information on the interaction of GLUT 1 and L-Arginine in sickle cell disease subjects. This study compared the bloo...
J D Schipke,A Deussen,F Moeller et al.
J D Schipke et al.
Owing to the unfamiliar environment, recreational and professional diving is confronted with several challenges. Usage of self-contained under-water breathing apparatuses during the dive provides the indispensable breathing gas supply for t...
Metabolic dysfunctions promoted by AIN-93G standard diet compared with three obesity-inducing diets in C57BL/6J mice [0.03%]
与三种诱导肥胖饮食相比AIN-93G标准饲料促进C57BL / 6 J小鼠的代谢功能障碍
Lais Marinho Aguiar,Carolina Soares de Moura,Cintia Reis Ballard et al.
Lais Marinho Aguiar et al.
Researchers from different fields have studied the causes of obesity and associated comorbidities, proposing ways to prevent and treat this condition by using a common animal model of obesity to create a profound energy imbalance in young a...
Long-term effects of multiple concussions on prefrontal cortex oxygenation during neurovascular coupling activation in retired male contact sport athletes [0.03%]
多次脑震荡对退役男性接触运动运动员神经血管耦合激活期间前额皮质氧合的长期影响
Luke W Sirant,Jyotpal Singh,Steve Martin et al.
Luke W Sirant et al.
Purpose: This study aimed to investigate the long-term effects of multiple concussions on prefrontal cortex oxygenation during a neurovascular coupling activating task using near infrared spectroscopy (NIRS). ...
Yu Yokoyama,Taiki Kodesho,Takuya Kato et al.
Yu Yokoyama et al.
This study examined the effect of chest mobilization on intercostal (IC) muscle stiffness using the IC muscle shear modulus. Sixteen healthy young men participated on two days with a minimum of 24 h between the stretching and control condit...
Skipping the first active meal appears to adversely alter reproductive function in female than male rats [0.03%]
与雄性大鼠相比，雌性大鼠跳过第一顿丰盛餐后似乎会不利地改变生殖功能
Oluwakemi T Oyelowo,Emmanuel O Taire,Olubunmi I Ajao
Oluwakemi T Oyelowo
There is a growing consciousness about chrono-nutrition and its physiological functions. The human feeding pattern establishes three meals a day, meal timing however may not be adhered to. Previous studies have reported ovarian dysfunctions...