Adrenergic control of the cardiovascular system in deer mice native to high altitude [0.03%]
高山原生小鹿鼠的肾上腺素控制心血管系统
Oliver H Wearing,Derek Nelson,Catherine M Ivy et al.
Oliver H Wearing et al.
Studies of animals native to high altitude can provide valuable insight into physiological mechanisms and evolution of performance in challenging environments. We investigated how mechanisms controlling cardiovascular function may have evol...
Hemodynamic patterns associated with activation of bradykinin-sensitive pericardial afferents [0.03%]
与缓激肽敏感的心包传入神经激活相关的血流动力学模式
Douglas Martin,Samuel Drummer,Jessica Freeling et al.
Douglas Martin et al.
The heart is endowed with reflexogenic areas capable of powerful blood pressure responses. Relatively little work has studied the hemodynamic mechanisms underlying these responses and whether these are sexually dimorphic. We hypothesized th...
The effects of voluntary wheel running during weight-loss on biomarkers of hepatic lipid metabolism and inflammation in C57Bl/6J mice [0.03%]
自愿跑步对C57Bl/6J小鼠体重减轻期间肝脏脂质代谢和炎症生物标志物的影响
Joshua S Wooten,Kaylee E Poole,Matthew P Harris et al.
Joshua S Wooten et al.
The aim of this study was to determine the effect of voluntary wheel running (VWR) during weight-loss on hepatic lipid and inflammatory biomarkers using a murine model. To induce obesity, male C57Bl/6 mice were fed a 60% high-fat diet (HF) ...
Diet-induced obese mice are resistant to improvements in cardiac function resulting from short-term adropin treatment [0.03%]
短期adropin治疗对饮食诱导的肥胖小鼠心脏功能改善无明显效果
Dharendra Thapa,Bingxian Xie,Bellina A S Mushala et al.
Dharendra Thapa et al.
Previous studies have shown that treatment with recombinant adropin, a circulating peptide secreted by the liver and brain, restores glucose utilization in the hearts of diet-induced obese mice. This restoration of fuel substrate flexibilit...
The effective use of blebbistatin to study the action potential of cardiac pacemaker cells of zebrafish (Danio rerio) during incremental warming [0.03%]
贝博司特用于研究斑马鱼心脏起搏细胞动作电位的高效应用——加温过程中的电生理学分析
L Marchant James,M Smith Frank,P Farrell Anthony
L Marchant James
Blebbistatin potently inhibits actin-myosin interaction, preventing contractile activity of excitable cells including cardiac myocytes, despite electrical excitation of an action potential (AP). We collected intracellular microelectrode rec...
A New Prospect for the Treatment of Nephrotic Syndrome Based on Network Pharmacology Analysis [0.03%]
基于网络药理学分析的治疗肾病综合征新策略研究
Rini Varghese,Anuradha Majumdar
Rini Varghese
Network pharmacology is an emerging field which is currently capturing interest in drug discovery and development. Chronic kidney conditions have become a threat globally due to its associated lifelong therapies. Nephrotic syndrome (NS) is ...
The air-breathing Alaska blackfish (Dallia pectoralis) remodels ventricular Ca2+ cycling with chronic hypoxic submergence to maintain ventricular contractility [0.03%]
缺氧淹没下阿拉斯加黑鱼重塑心室Ca2+循环以维持心室收缩力
Holly A Shiels,Ed White,Christine S Couturier et al.
Holly A Shiels et al.
The Alaska blackfish (Dallia pectoralis) is a facultative air-breather endemic to northern latitudes where it remains active in winter under ice cover in cold hypoxic waters. To understand the changes in cellular Ca2+ cycling that allow the...
Intergenerational protein deficiency and adolescent reproductive function of subsequent female generations (F1 and F2) in rat model [0.03%]
蛋白质代际缺乏对大鼠模型后代（F1和F2代）青春期生殖功能的影响
Nosarieme O Abey,Osaretin A T Ebuehi,Ngozi O A Imaga
Nosarieme O Abey
Background: Efficient reproductive function is an important characteristic that has evolved through natural selection. Nutrition can modulate reproductive activities at different levels, and its effect on reproduction is ...
The Impact of beta blockade on the cardio-respiratory system and symptoms during exercise [0.03%]
β受体阻滞剂对运动时的心血管呼吸系统及症状的影响
Eldar Priel,Mustafaa Wahab,Tapas Mondal et al.
Eldar Priel et al.
Background: Beta blockers prolong life in patients with cardiovascular diseases. Negative chronotropic and inotropic effects carry the potential to adversely effect peripheral skeletal and airway smooth muscle contributin...
Crystal A West,Steven D Beck,Shyama M E Masilamani
Crystal A West
Progressive sodium retention and cumulative plasma volume expansion occur to support the developing fetus during pregnancy. Sodium retention is regulated by individual tubular transporters and channels. An increase or decrease in any single...