Cholestyramine treatment in two dogs with presumptive bile acid diarrhoea: a case report [0.03%]
两例疑似胆盐腹泻犬应用胆固醇树脂治疗的病例报道
L Toresson,J M Steiner,J S Suchodolski
L Toresson
Background: In people, bile acid diarrhoea is a prevalent complication of Crohn's disease and diarrhoea-associated irritable bowel syndrome. Affected patients typically respond to bile acid sequestrants, such as cholestyr...
Short and sweet: foreleg abnormalities in Havanese and the role of the FGF4 retrogene [0.03%]
简明扼要：FGF4内含子3剪接位点突变导致哈瓦那犬前肢异常
Kim K L Bellamy,Frode Lingaas
Kim K L Bellamy
Background: Cases of foreleg deformities, characterized by varying degrees of shortened and bowed forelegs, have been reported in the Havanese breed. Because the health and welfare implications are severe in some of the a...
The usage of Mate Select, a web-based selection tool for pedigree dogs for promoting sustainable breeding [0.03%]
一种促进犬可持续繁殖的网络工具Mate Select的应用
Mateja Janes,Thomas W Lewis,Joanna J Ilska et al.
Mateja Janes et al.
Background: Inbreeding is a phenomenon that accumulates through the mating of relatives within closed populations, such as pedigree dog breeds, and results in reduced genetic variation within breeds, and may lead to poore...
Evaluation for type 1 diabetes associated autoantibodies in diabetic and non-diabetic Australian terriers and Samoyeds [0.03%]
评估澳大利亚牧羊犬和雪撬犬糖尿病自身抗体水平及相关因素
Allison L O&#x;Kell,Clive H Wasserfall,Paula S Henthorn et al.
Allison L O&#x;Kell et al.
Background: Evidence for an autoimmune etiology in canine diabetes is inconsistent and could vary based on breed. Previous studies demonstrated that small percentages of diabetic dogs possess autoantibodies to antigens kn...
Initial survey of PLA2G6 missense variant causing neuroaxonal dystrophy in Papillon dogs in North America and Europe [0.03%]
美洲和欧洲波尔帮犬神经轴索变性病PLA2G6错义变异初步调查
Karthik Raj,Urs Giger
Karthik Raj
Background: An autosomal recessive, rapidly progressive degenerative neuropathy known as infantile neuroaxonal dystrophy (NAD) was originally reported in Papillion puppies in 1995. In 2015, a causative missense variant in...
Comprehensive genetic testing combined with citizen science reveals a recently characterized ancient MC1R mutation associated with partial recessive red phenotypes in dog [0.03%]
结合公民科学的全面基因检测发现了一个与狗部分隐性红表型相关的最近被确定的古老MC1R突变
Heidi Anderson,Leena Honkanen,Päivi Ruotanen et al.
Heidi Anderson et al.
Background: The Melanocortin 1 Receptor (MC1R) plays a central role in regulation of coat color determination in various species and is commonly referred to as the "E (extension) Locus". Allelic variation of the MC1R gene...
Breeding schemes for intervertebral disc disease in dachshunds: Is disc calcification score preferable to genotyping of the FGF4 retrogene insertion on CFA12? [0.03%]
长腿达克斯犬椎间盘疾病的育种计划：CFA12上的FGF4转座子插入基因分型是否可被椎间盘钙化评分取代？
Camilla Sichlau Bruun,Charlotte Bruun,Tine Marx et al.
Camilla Sichlau Bruun et al.
Background: Approximately every fifth Dachshund is affected by disc herniation - a painful, hereditary condition which is typically preceded by disc calcification. Therefore, the selection of dogs suitable for breeding ca...
Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds [0.03%]
特定犬品种中的犬白细胞抗原（DLA）II类表型与糖尿病风险关系的研究
A L Denyer,J P Massey,L J Davison et al.
A L Denyer et al.
Background: Canine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, ...
Effects of calcitriol on oxidative burst, phagocytic function, and leukocyte cytokine production in shelter dogs [0.03%]
维生素D对收容所中狗狗氧化爆发、吞噬功能和白细胞细胞因子生成的影响
Jared A Jaffey,Mariah Bessette,Zenan Tao et al.
Jared A Jaffey et al.
Background: The active metabolite of vitamin D, calcitriol, has been shown across many different species to augment innate immune responses and dampen aberrant proinflammatory cytokine production. Community acquired infec...
Lifespan of companion dogs seen in three independent primary care veterinary clinics in the United States [0.03%]
在美国三家独立的一站式宠物诊所看到的伴侣狗的寿命研究
Silvan R Urfer,Matt Kaeberlein,Daniel E L Promislow et al.
Silvan R Urfer et al.
Background: The privately owned companion dog is an emerging model in comparative medicine, notably because it shares the human environment including its risk factors, is affected by many analogous age-related diseases, r...