A novel RELA K119 deacetylation mediated by SIRT7 is a pivotal activator to exacerbate liver inflammation and fibrosis in teleosts [0.03%]
TELOSTS 中一种由SIRT7介导的RELA K119去乙酰化的新机制可作为加重肝脏炎症和纤维化的关键激活因子
Xiaoliang Wu,Xiaofang Liang,Min Li et al.
Xiaoliang Wu et al.
Post-translational modifications (PTMs) regulate the activity and functionality of RELA, but their role in the pathogenesis of liver fibrosis is unclear. This study was performed to understand the regulation mechanism of acetylation of RELA...
Impact of dispersion correction in DFT-enhanced anisotropic NMR for stereochemical elucidation of flexible marine natural products [0.03%]
色散校正对DFT增强各向异性NMR在手性灵活的海洋天然产物结构解析中的影响
Lu-Ping Chi,Xiao-Lu Li,Anton F Ketzel et al.
Lu-Ping Chi et al.
Although anisotropic NMR spectroscopy has emerged as a powerful method for determining the relative configuration of complex natural products, major challenges persist with structurally flexible molecules. In this study, we conducted a syst...
Antibacterial dimeric phenazine derivatives from a marine-derived Streptomyces sp. OUCMDZ-4923 [0.03%]
来源于海洋微生物Streptomyces sp. OUCMDZ-4923的抗菌菲挫二聚衍生物
Dongyang Wang,Peipei Liu,Yuwei Xia et al.
Dongyang Wang et al.
Phenazine derivatives, a class of naturally occurring antibiotics primarily produced by bacteria, are regarded as promising scaffolds for developing new antibiotics. In this study, eight new dimeric phenazine derivatives, phenazostains K‒R...
Metamorphosis in Aurelia aurita from polyp to medusa: assessing composition and metabolism throughout development [0.03%]
月龄水母(Aurelia aurita)从多能干细胞到水母的变态：在整个发育过程中评估组成和代谢状况
Vanesa Romero-Kutzner,Daniel R Bondyale-Juez,Ico Martínez et al.
Vanesa Romero-Kutzner et al.
Aurelia aurita exhibits a triphasic life cycle involving metamorphosis, transitioning from sessile polyps to free-swimming ephyrae and eventually maturing into medusae. This metamorphic process is triggered by a reduction in temperature. In...
Anammox and denitrifying bacteria and their nitrogen removal potential in lake sediments mediated by environmental changes [0.03%]
环境变化调控的湖泊沉积物中厌氧氨氧化菌和反硝化细菌的氮去除潜能及相互作用机制研究
Mamun Abdullah Al,Yunfeng Wang,Jie Huang et al.
Mamun Abdullah Al et al.
Anammox and denitrification are key processes for nitrogen removal in lake sediments. However, how environmental changes mediate the community structure and functional genes of nitrogen removal bacteria in lakes remain unclear. Using metage...
Ecological diversity and metabolic strategies of widespread Marinisomatota in global oceans [0.03%]
全球海洋中广泛存在的Marinisomatota的生态多样性和代谢策略
Shizheng Xiang,Jianyang Li,Zhen Chen et al.
Shizheng Xiang et al.
Marinisomatota (formerly recognized as Marinimicrobia, Marine Group A, and SAR406) are ubiquitous and abundant in marine environments, traditionally characterized as heterotrophic microorganisms. However, certain members of Marinisomatota h...
Picocyanobacteria in the Chesapeake Bay: isolation, diversity, and adaptation [0.03%]
切萨皮克湾纤细蓝藻的分离、多样性及适应性研究
Feng Chen
Feng Chen
Tiny unicellular cyanobacteria or picocyanobacteria (0.5-3 µm) are important due to their ecological significance. Chesapeake Bay is a temperate estuary that contains abundant and diverse picocyanobacteria. Studies of Chesapeake Bay picocy...
Metabolomic profiling reveals that the heterogeneity of microhabitats can assist intertidal mollusks in surviving extreme cold events [0.03%]
代谢组学分析表明，微生境的异质性有助于潮间带软体动物抵御极端寒冷事件
Ning Zhang,Chen-Ming Lv,Xiao-Ning Zhang et al.
Ning Zhang et al.
Microhabitat heterogeneity results in significant variations in the thermal environment on a small spatial scale, leading to different intensities of cold stress during extreme low-temperature events. Investigating variations in body temper...
Mitochondrial membrane remodeling during heat acclimation in Mongolian gerbils [0.03%]
热习服蒙古仓鼠线粒体膜的重塑现象
Qian Pan,Xin-Yu Liu,Fuyu Shi et al.
Qian Pan et al.
Mongolian gerbils had high ability to endure both high and cold temperatures. To study the mechanism of high ability for thermal adaptation, gerbils were acclimated to high temperature (30 °C) for 8 weeks, and were measured for metabolic f...
Seasonality, worker caste, and the interaction between island area and habitat type influence the thermal tolerance of ants on fragmented habitat islands [0.03%]
季节性、工人等级以及岛屿面积和生境类型间的相互作用影响碎片化生境岛屿上蚂蚁的耐热性
Yuhao Zhao,Chenxiao Wu,Chi Man Leong et al.
Yuhao Zhao et al.
Habitat fragmentation is a major cause of biodiversity loss. Fragmentation can alter thermal conditions on the remaining patches, especially at habitat edges, but few studies have examined variations in thermal tolerance of species in fragm...