Distinct evolutionary origins and mixed-mode transmissions of methanogenic endosymbionts are revealed in anaerobic ciliated protists [0.03%]
厌氧纤毛虫产生甲烷的内共生体具有不同的起源和混合传播模式
Tingting Hao,Hua Su,Zijing Quan et al.
Tingting Hao et al.
Methanogenic endosymbionts are the only known intracellular archaeans and are especially common in anaerobic ciliated protists. Studies on the evolution of associations between anaerobic ciliates and their methanogenic endosymbionts offer a...
Integrative analysis of coral plasticity and adaptations reveals key proteins driving resilience to changes in ocean carbonate chemistry [0.03%]
整合分析珊瑚的可塑性和适应性揭示驱动珊瑚应对海洋酸化的关键蛋白
Xiangcheng Yuan,Ellias Y Feng,Jingtian Wang et al.
Xiangcheng Yuan et al.
Understanding how corals adapt to changes in seawater carbonate chemistry is crucial for developing effective coral conservation strategies. Research to date has mostly focused on short-term experiments, overlooking long-term evolutionary e...
Sesquiterpenoids from the hydrothermal vent sediment derived fungus Penicillium sp. JWM79-5-1 with antithrombotic and pro-angiogenic activities [0.03%]
一种深海分离真菌Penicillium sp. JWM79-5-1中具有抗血栓和促血管生成活性的倍半萜类化合物
Wenjuan Ding,Xiaobin Li,Xiyue Wang et al.
Wenjuan Ding et al.
Seven previously unreported sesquiterpenes including three rare 5/5/6-fused tricyclic gymnomitrane-type sesquiterpenes (1-3), an ent-longipinane-type sesquiterpene (4), a cuparane-type sesquiterpene (5), and two chamigrane-type sesquiterpen...
The distribution of antibiotic resistance and virulence factor genes in the sediment of Inexpressible Island, East Antarctica [0.03%]
南极不可表达岛沉积物中抗生素抗性基因和毒力因子基因的分布特征
Ruyi Dong,Yongqin Liu,Ninglian Wang et al.
Ruyi Dong et al.
Inexpressible Island is a small rocky island in Terra Nova Bay, Victoria Land, Antarctica, which is an area with limited human activities. Understanding the distribution of antibiotic-resistance genes (ARGs) and virulence factor genes (VFGs...
Taurine alleviates endoplasmic reticulum stress, oxidative stress, apoptosis, and glycogen accumulation induced by high glucose in the muscle cells of golden pompano (Trachinotus ovatus) [0.03%]
牛磺酸通过缓解金线鱼（Trachinotus ovatus）肌细胞高糖诱导的内质网应激、氧化应激、凋亡及糖原累积而发挥保护作用
Ming-Jian Liu,Lu-Ke Zhang,Ke-Cheng Zhu et al.
Ming-Jian Liu et al.
High-glucose environments induce cellular stress, particularly endoplasmic reticulum stress (ERS) and oxidative stress, in aquatic animals. Taurine, known for its cell-protective properties, has potential in mitigating such stress. This stu...
Molecular mechanism of the crosstalk between glucocorticoid receptor (GR) and hypoxia-inducible factor 3α (HIF-3α) pathways [0.03%]
糖皮质激素受体（GR）与低氧诱导因子3α（HIF-3α）信号通路互作的分子机制研究
Meina Zhang,Yang Guo,Xiaotong Diao et al.
Meina Zhang et al.
Glucocorticoids, crucial regulatory hormones involved in the stress response, significantly influence growth, development, and metabolism through activation of the glucocorticoid receptor (GR). Hypoxia-inducible factor 3 alpha (HIF-3α), th...
Identifying potential keystone bacterial species within the phycosphere of marine algae and unveiling their metabolic characteristics [0.03%]
识别海洋藻类光球内潜在的关键细菌种类及其代谢特性
Jeong Min Kim,Byeong Jun Choi,Hülya Bayburt et al.
Jeong Min Kim et al.
Metabolic interactions between microbiomes and algal hosts within the phycosphere of marine macroalgae are drawing increasing attention due to their roles in food webs, global nutrient cycles, industries, and their potential as food resourc...
MR2938 relieves DSS-induced colitis in mice through inhibiting NF-κB signaling and improving epithelial barrier [0.03%]
MR2938通过抑制NF-κB信号传导并改善上皮屏障来缓解DSS诱导的小鼠结肠炎
Ling Lv,Mireguli Maimaitiming,Shuli Xia et al.
Ling Lv et al.
Damage to the epithelial barrier is among key processes contributing to initiation and chronic inflammation in inflammatory bowel diseases (IBD). Only management therapy exists for IBD (e.g., anti-inflammatory and immunomodulatory agents, J...
Development of cell labeling and gene editing tools in urochordate Ciona [0.03%]
尾索动物Ciona中细胞标记和基因编辑工具的研发
Xiang Li,Lu Mu,Hongzhe Peng et al.
Xiang Li et al.
Urochordate Ciona spp. are ideal marine model organisms for studying embryogenesis and developmental and evolutionary biology. However, the effective implementation of genetic labeling and CRISPR/Cas9-based editing tools at cellular resolut...
Multi-omics analysis guided discovery: hydroxyproline enhance muscle hardness of hybrid bream (BBTB, Megalobrama amblycephala ♀ × Culter alburnus ♂) via myofiber proliferation and collagen deposition [0.03%]
多组学分析指导下的发现：羟脯氨酸通过肌纤维增殖和胶原沉积提高团头鲂（团头鲂♀×拟鲤♂）的肌肉硬度
Anli Zuo,Zhehua Xu,Yimiao He et al.
Anli Zuo et al.
Hardness is widely regarded as a critical factor influencing the whole texture of fish flesh. The objective of this study was to elucidate the regulatory mechanism underlying muscle hardness in hybrid bream (BBTB, Megalobrama amblycephala ...