The sterols-LXR axis alleviates IL-17-mediated acute inflammatory response in Apostichopus japonicus [0.03%]
胆甾醇-LXR轴缓解Apostichopus japonicus急性炎性反应中的IL-17介导机制
Si Zhu,Zhimeng Lv,Jiqing Liu et al.
Si Zhu et al.
Inflammation plays a crucial role in defending the host against pathogens and other harmful stimuli. However, uncontrolled acute inflammation has been implicated in a multitude of diseases, including those that affect aquatic animals. While...
Glycogenic hepatopathy in a primitive teleost fish model: the inductive effect of high carbohydrate diet and the alleviating role of betaine [0.03%]
高碳水化合物饮食诱导的鱼类糖原性肝病及甜菜碱对其的缓解作用研究
Jiahong Zou,Zhenwei Chen,Feifei Zheng et al.
Jiahong Zou et al.
Carbohydrate-induced glycogenic hepatopathy is underdiagnosed and difficult to discriminate from hepatic steatosis in humans. The present study used liver biopsy and other diagnostic tools, and adopted metabolomic technology to identify gly...
Trash or treasure? Unlocking dark matter of enantiomeric natural products in innovative drugs discovery for potent angiogenesis inhibitors [0.03%]
废品还是宝藏？开发潜在抗血管生成药物时利用天然产物对映异构体的阴暗面
Yan-Wei Wu,Xiao-Feng Mou,Zhong-Yuan Chen et al.
Yan-Wei Wu et al.
The occurrence and development of tumors rely on the nutritional supply from blood vessels, which also serve as the main pathway for tumor metastasis. Inhibiting angiogenesis is one of the main strategies for cancer treatments. Chiral drugs...
A hybrid assembly mechanism employs nonreducing polyketide synthase-like logic for partially reduced polyketide formation [0.03%]
一种杂合组装机制利用非还原型聚酮合酶样逻辑产生部分还原型聚酮化合物
Xianyan Zhang,Chuanteng Ma,Ziguang Deng et al.
Xianyan Zhang et al.
Fungal iterative type I polyketide synthases (iPKSs) are commonly classified into nonreducing (NR-), partially reducing (PR-), and highly reducing (HR-) polyketide synthases based on their assembly mechanisms and domain structures. These iP...
Environmental drivers and key taxa shaping diatom-dinoflagellate ratios in eutrophic coastal waters [0.03%]
富营养化近海环境中驱动硅藻和甲藻比值的关键环境因子和关键类群
Lingshuai Zhang,Zhiqin Wang,Jin-Yu Terence Yang et al.
Lingshuai Zhang et al.
Diatoms and dinoflagellates are two pivotal phytoplankton groups present in coastal ecosystems that play key roles in marine food webs and biogeochemical cycles. The diatom-to-dinoflagellate ratio (diat/dino ratio) serves as an indicator of...
Caspase-mediated interleukin-18 maturation promotes membrane-associated unconventional secretion and signal transduction in a teleost fish [0.03%]
半胱天冬酶介导的IL-18成熟促进鱼类非常规膜相关分泌和信号转导
Liming Yuan,Hang Xu,Shuai Jiang
Liming Yuan
Interleukin-18 (IL-18) is an important proinflammatory cytokine essential for immune modulation. Unlike most cytokines, it is synthesized as an inactive precursor, with its maturation and secretion being critical for its functionality. As a...
New activities of homoyessotoxin against lung cancer through the regulation of EGFR/PI3K/AKT pathway [0.03%]
通过调节EGFR/PI3K/AKT途径抗肺癌的_homoyessotoxin_新活性
Kuilin Chen,Xinyu Gao,Jiapeng Li et al.
Kuilin Chen et al.
Non-small cell lung cancer (NSCLC) remains a major cause of cancer-related mortality worldwide, emphasizing the need for novel therapeutic strategies. In this study, we demonstrate that homoyessotoxin (hYTXs), a marine-derived natural compo...
Isochrysis zhanjiangensis exhibits protective effects against metabolic abnormalities induced by high-fat diet in mice [0.03%]
异藻伊势等鞭金黄藻保护高脂饮食诱导的小鼠代谢异常
Mei Wu,Yu Bai,Yanrong Li et al.
Mei Wu et al.
While Isochrysis zhanjiangensis, a marine microalga, has been widely adopted in aquaculture for its health-promoting properties, its potential as a functional food for human metabolic health remains unexplored. To bridge this gap, this stud...
General transcription factor IIIAa regulates the transcription of somatic 5S rRNA and influences embryonic organ development in zebrafish [0.03%]
斑马鱼一般转录因子IIIAA调控卵黄囊5S核糖体基因转录并影响胚胎器官发生
Junzhi Luo,Binbin Tao,Ji Chen et al.
Junzhi Luo et al.
Transcription factor IIIA (TFIIIA) is a zinc finger protein that facilitates the assembly of a transcription complex by recruiting transcription factors TFIIIB and TFIIIC, along with RNA polymerase III, to initiate the transcription of 5S r...
Distinct ecophysiological characteristics of two genetically similar vibriophages [0.03%]
两个基因相似的噬菌体的不同的生态生理特征
Wenqing Li,Runqi Zhu,Keming Shi et al.
Wenqing Li et al.
Vibrio parahaemolyticus is a marine bacterium and a causative agent of gastroenteritis in humans. Phages targeting V. parahaemolyticus serve as natural antagonists to this pathogen, significantly controlling its population and, consequently...