Molecular networking reveals indole diterpenoids from the marine-derived fungus Penicillium sp. N4-3 [0.03%]
基于分子网络技术从海洋来源真菌Penicillium sp. N4-3中发现吲哚二萜类化合物
Min Chen,Bao-Cong Hao,Xia-Hao Zhu et al.
Min Chen et al.
MS/MS-based molecular networking is an effective strategy to rapidly dereplicate known compounds and to guide the discovery process for new and novel natural products. In the present study, the chemical diversity of indole diterpenoids from...
Rediscovery and morpho-molecular characterization of three astome ciliates, with new insights into eco-evolutionary associations of astomes with their annelid hosts [0.03%]
三种刺胞虫的再发现及形态分子特征分析，并揭示了刺胞虫与其环节动物宿主间的生态进化关系的新见解
Tomáš Obert,Tengyue Zhang,Ivan Rurik et al.
Tomáš Obert et al.
Astome ciliates live in the digestive tract of a broad spectrum of marine, freshwater, and terricolous annelids. In aquatic lumbriculid and criodrilid oligochaetes collected in Central Europe, we rediscovered three insufficiently known asto...
Osmoregulatory evolution of gills promoted salinity adaptation following the sea-land transition of crustaceans [0.03%]
甲壳动物海水陆地转换后渗透调节进化促进盐度适应性变迁
Hongguang Liu,Xiaokun Wang,Zeyu Liu et al.
Hongguang Liu et al.
The sea-land transition is one of the most dramatic evolutionary changes and requires an adaptive genetic response to salinity changes and osmotic stress. Here, we used multi-species genomes and multi-tissue transcriptomes of the talitrid c...
Zglp-1 is a novel essential transcriptional regulator for sex reversal in zebrafish [0.03%]
斑马鱼性别转变的新型关键转录调控因子ZGLP-1
Yajun Wang,Gaoqian Xu,Haoyi Li et al.
Yajun Wang et al.
Sex determination and differentiation play crucial biological roles in sexual reproduction in vertebrates, including zebrafish. Nevertheless, the intricate molecular mechanisms governing these processes have remained enigmatic. In this stud...
Penicipyrrolidines A-N, pyrrolidine derivatives with inhibitory effects on EMT and fibroblast activation from the mangrove-derived fungus Penicillium sp. DM27 [0.03%]
来源于互花米草相关真菌Penicillium sp. DM27的EMT和成纤维细胞活化抑制剂Pencipyrrolidines A-N
Li-Ming He,Xuan Deng,Li-Hua Ni et al.
Li-Ming He et al.
An investigation of the mangrove-derived fungus Penicillium sp. DM27 led to the isolation of 19 new compounds, including three pairs of piperidinone enantiomers ( ±)-1, ( ±)-2, and ( ±)-3, two pairs of pyrrolidinone enantiomers ( ±)-4 a...
Insights into the recognition mechanism of shark-derived single-domain antibodies with high affinity and specificity targeting fluoroquinolones [0.03%]
一种针对氟喹诺酮类药物的高亲和力特异性抗体识别机制的新见解
Chang Liu,Guoqiang Li,Yuan Chen et al.
Chang Liu et al.
In this study, we investigated the molecular recognition mechanisms of shark-derived single-domain antibodies (ssdAbs) targeting fluoroquinolones using an integrated approach that combines in silico homologous modeling, molecular dynamics s...
Decoupling of bacterial production and respiration in the surface water of the North Pacific Subtropical Gyre [0.03%]
北太平洋副热带环流表层水中细菌生产与呼吸的脱钩现象
Yuchen Zhang,Yibin Huang,Feipeng Xu et al.
Yuchen Zhang et al.
Heterotrophic bacterial production and respiration, two important contributors to carbon cycling, play an important role in global biogeochemical cycles. However, recent research suggests that these two processes may be decoupled, and the u...
The first dimeric indole-diterpenoids from a marine-derived Penicillium sp. fungus and their potential for anti-obesity drugs [0.03%]
来自海洋真菌的首个二聚吲哚二萜及它们在抗肥胖药物中的潜在应用
Hui-Fang Du,Lei Li,Ya-Hui Zhang et al.
Hui-Fang Du et al.
Obesity has become a worldwide health problem. Seeking natural products with anti-obesity activity from lots of fungi has drawn the attention of pharmacologists. In our study, dipenipenoids A and B (1 and 2), the first dimeric indole-diterp...
Hepcidin peptide controls the inflammatory response induced by betanodavirus infection and improves European sea bass (Dicentrachus labrax) survival [0.03%]
Hepcidin肽控制由betanodavirus感染引发的炎症反应并提高欧洲海鲈(Dicentrachus labrax)的存活率
Laura Cervera,Marta Arizcun,Luis Mercado et al.
Laura Cervera et al.
Nervous necrosis virus (NNV) is the etiological agent of viral encephalopathy and retinopathy in many fish species, including European sea bass (Dicentrachus labrax) and is of great economic losses to fish farmers. To solve this problem in ...
Genomic evidence for demographic fluctuations, genetic burdens and adaptive divergence in fourfinger threadfin Eleutheronema rhadinum [0.03%]
四种鳍四个手指线EndElement的种群波动，遗传负荷和适应性分歧的基因组证据
Jie Xiao,Wen-Xiong Wang
Jie Xiao
Declining populations and bottlenecks lead to the accumulation of deleterious mutations in fish populations. These processes also trigger genetic purging, which is a key genetic factor in reducing the deleterious burdens and increasing popu...