DLBCL cells emerge post CD19 CAR-T with cross-antigen resistance and a gene signature predictive of clinical CAR-T response [0.03%]
CD19-CAR-T治疗后肿瘤复发的DLBCL细胞产生获得交叉抗原耐药性及预测CAR-T临床疗效的基因特征
Fabiana Lϋӧnd,Jeanne Whalen,Youngchul Song et al.
Fabiana Lϋӧnd et al.
Current understanding of lymphoma cell-intrinsic mechanisms of relapse following CAR-T cell treatment of diffuse large B-cell lymphoma (DLBCL) include antigen-loss and apoptosis resistance. Herein, CD19 CAR-T response and resistance were mo...
The Silence of the Lambdas: Hidden Complexities in the Evolution of Double-Hit Lymphomas [0.03%]
lamda沉默：双打击淋巴瘤进化中隐藏的复杂性
Galina Shevchenko,Daniel J Hodson
Galina Shevchenko
In this issue of Blood Cancer Discovery, Varano and colleagues uncover a substantial fraction of high-grade B-cell lymphoma with MYC and BCL2(-BCL6) translocations (so called "double-hit" lymphomas or high-grade B-cell lymphoma-double-hit-B...
Clinical Significance of TP53-Mutant Clonal Hematopoiesis Across Diseases [0.03%]
TP53突变克隆型血液病在不同疾病状态下的临床意义
Yoshiaki Usui,Mikiko Endo,Yusuke Iwasaki et al.
Yoshiaki Usui et al.
Clonal hematopoiesis of indeterminate potential (CHIP) has broad clinical relevance, and TP53 plays various roles within cells. However, the gene-specific and cross-disease significance of CHIP with TP53 mutations (TP53-CHIP) remains unclea...
Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia [0.03%]
遗传背景对T细胞急性淋巴细胞白血病基因组及生存结果的影响
Haley Newman,Shawn H R Lee,Petri Pölönen et al.
Haley Newman et al.
The influence of genetic ancestry on genomics in T-cell Acute Lymphoblastic Leukemia (T-ALL) has not been fully explored. We examined the impact of genetic ancestry on multi-omic alterations, survival outcomes, and risk stratification. Amon...
B cell receptor silencing reveals origin and dependencies of high-grade B cell lymphomas with MYC and BCL2 rearrangements [0.03%]
B细胞受体沉默揭示MYC和BCL2重排的高级别B细胞淋巴瘤的起源和依赖性
Gabriele Varano,Silvia Lonardi,Paola Sindaco et al.
Gabriele Varano et al.
The B cell receptor (BCR) is critical for mature B cell lymphomas, serving as a therapeutic target. We show that high-grade B cell lymphomas with MYC and BCL2 rearrangements (HGBCL-DH-BCL2) predominantly exhibit immunoglobulin heavy (IGH) c...
Mutagenic impact and evolutionary influence of chemo-radiotherapy in hematologic malignancies [0.03%]
化疗和放疗在血液系统恶性肿瘤中的致突变作用及对进化的影响
Benjamin Diamond,Dhanvantri Chahar,Michael D Jain et al.
Benjamin Diamond et al.
Ionizing radiotherapy (RT) is a widely used treatment strategy for malignancies. In solid tumors, RT-induced double-strand breaks lead to the accumulation of indels, and their repair by non-homologous end-joining has been linked to the ID8 ...
Genetic and Phenotypic correlates of clinical outcomes with Venetoclax in Acute Myeloid Leukemia: The GEN-PHEN-VEN study [0.03%]
维奈克拉治疗急性髓系白血病的临床疗效相关的遗传和表型关联：GEN-PHEN-VEN 研究
Curtis A Lachowiez,Mael Heiblig,Gaspar Aspas Requena et al.
Curtis A Lachowiez et al.
Resistance to venetoclax-based therapy in acute myeloid leukemia (AML) includes genetic (i.e., mutations in N/KRAS, FLT3-ITD, TP53) and phenotypic (i.e., monocytic differentiation) features. Whether monocytic differentiation contributes to ...
Jonas Berger,Livius Penter
Jonas Berger
This article presents a novel computational tool, "BoneMarrowMap," that enables the mapping of leukemic single-cell RNA sequencing datasets to hematopoietic differentiation states. By utilizing BoneMarrowMap for a large-scale single-cell RN...
Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation [0.03%]
单细胞转录组图谱揭示了遗传和层次决定因素对人类白血病分化的影响
Andy G X Zeng,Ilaria Iacobucci,Sayyam Shah et al.
Andy G X Zeng et al.
We present a single-cell reference atlas of human hematopoiesis and a computational tool for rapid mapping and classification of healthy and leukemic cells. Applied to AML, this has enabled single-cell analysis at the scale of hundreds of p...
Single-Cell Resolved Oncogene Co-expression: From Principles to Clinical Impact [0.03%]
单细胞解析癌基因共表达：从原理到临床影响
Shruti Sridhar,Allison S Y Chan,Anand D Jeyasekharan
Shruti Sridhar
This commentary explores the concept and utility of studying oncogene co-expression at single-cell resolution and its clinical and biological implications. We emphasize the importance of scalable methods, mathematically driven quantificatio...