Real-World Experience with Teclistamab for Relapsed/Refractory Multiple Myeloma from the US Myeloma Immunotherapy Consortium [0.03%]
美国多发性骨髓瘤免疫治疗联盟中泰克利司玛治疗复发/难治性多发性骨髓瘤的真实世界经验
Beatrice M Razzo,Shonali Midha,Andrew J Portuguese et al.
Beatrice M Razzo et al.
Teclistamab is an anti-CD3-/B-cell maturation antigen (BCMA) bispecific antibody approved for use in relapsed/refractory multiple myeloma. We undertook a retrospective study of postapproval, real-world outcomes with teclistamab in the US Mu...
Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia [0.03%]
遗传背景对T细胞急性淋巴细胞白血病基因组及生存结果的影响
Haley Newman,Shawn H R Lee,Petri Pölönen et al.
Haley Newman et al.
The influence of genetic ancestry on genomics in T-cell acute lymphoblastic leukemia (T-ALL) has not been fully explored. We examined the impact of genetic ancestry on multiomic alterations, survival outcomes, and risk stratification. Among...
Food for Thought: Addressing a Research Gap for Dietary Trials in Hematologic Malignancies [0.03%]
值得思考的膳食：造血系统恶性肿瘤膳食试验研究中的一个缺口及其对策
Akash Patel,Shireen Kassam,Urvi A Shah
Akash Patel
There is growing interest from both patients and clinicians in understanding the role nutrition plays across hematologic malignancies. In this study, we highlight key unanswered questions related to studying dietary interventions in hematol...
Adam J de Smith
Adam J de Smith
In this issue of Blood Cancer Discovery, Newman and colleagues investigated the impact of genetic ancestry on molecular subtypes, genomic alterations, and survival outcomes in a diverse cohort of patients with T-cell acute lymphoblastic leu...
IRF4 promotes immune evasion and shapes the tumor microenvironment in Follicular Lymphoma [0.03%]
IRF4促进免疫逃逸并塑造滤泡淋巴瘤的肿瘤微环境
Surendra Dasari,Kerstin Wenzl,Geoffrey M Nelson et al.
Surendra Dasari et al.
Twenty percent of follicular lymphoma (FL) patients relapse early with poor outcomes; however, the molecular mechanisms underlying this aggressive behavior are unknown. Using a multi-omics approach, we show that FL patients with elevated IR...
Microbiota shape metabolic and immune determinants of CAR-T therapy and correlate with outcomes in myeloma [0.03%]
微生物群影响CAR-T治疗的代谢和免疫特征并与多发性骨髓瘤预后相关
Mireia Uribe-Herranz,Aina Oliver-Caldés,Neus Martínez-Micaelo et al.
Mireia Uribe-Herranz et al.
Multiple myeloma remains incurable despite advances in immunotherapies like CAR-T cell therapy. This study investigates the role of metabolites and gut microbiota in clinical outcomes in patients treated with the humanized BCMA-directed CAR...
An isoform-specific RUNX1C-BTG2 axis governs AML quiescence and chemoresistance [0.03%]
RUNX1C-BTG2轴调控AML细胞休眠和耐药性
Cuijuan Han,Zhiping Zhang,Edie I Crosse et al.
Cuijuan Han et al.
Aberrant levels or structures of RNA isoforms are a hallmark of many cancers, including acute myeloid leukemia (AML), yet its role in AML chemoresistance remains unclear. We conducted a paired analysis of RNA isoform changes in AML patients...
Real-World Experience with Teclistamab for Relapsed/ Refractory Multiple Myeloma from the U.S. Myeloma Immunotherapy Consortium [0.03%]
来自美国多发性骨髓瘤免疫治疗联盟的Teclistamab治疗复发/难治性多发性骨髓瘤的真实世界经验
Beatrice M Razzo,Shonali Midha,Andrew J Portuguese et al.
Beatrice M Razzo et al.
Teclistamab is an anti-CD3xBCMA bispecific antibody approved for use in relapsed/refractory multiple myeloma (MM). We undertook a retrospective study of post-approval, real-world outcomes with teclistamab in the U.S. MM Immunotherapy Consor...
Multi-Modal and Data-Driven Assessment of Myeloid Neoplasms Refines Classification Across Disease States [0.03%]
跨疾病状态的髓系肿瘤多模态和数据驱动型评估可细化分类结果
Curtis A Lachowiez,Georgios Asimomitis,Elsa Bernard et al.
Curtis A Lachowiez et al.
The World Health Organization (WHO) 5th edition and International Consensus Classification (ICC) for myeloid neoplasms both incorporate empirical numerical thresholds to morphologic and molecular features defining certain disease entities. ...
Commensal bacteria drive B-cell lymphomagenesis in the setting of innate immunodeficiency [0.03%]
原发性免疫缺陷情况下共生细菌驱动B淋巴细胞瘤的产生
Jaeyong Jung,Sining Zhu,Almin Lalani et al.
Jaeyong Jung et al.
Myeloid cells are central players in innate immunity and inflammation. Their function is regulated by the adaptor protein TRAF3. We previously reported that aging myeloid cell-specific TRAF3-deficient (M-Traf3-/-) mice spontaneously develop...