BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity [0.03%]
BCOR通过改变EYA1，SIX和MYC活性结合到MLL-AF9上对白血病至关重要
Charles R Schmidt,Nicholas J Achille,Aravinda Kuntimaddi et al.
Charles R Schmidt et al.
MLL is a target of chromosomal translocations in acute leukemias with poor prognosis. The common MLL fusion partner AF9 (MLLT3) can directly bind to AF4, DOT1L, BCOR, and CBX8. To delineate the relevance of BCOR and CBX8 binding to MLL-AF9 ...
Monosomic loss of MIR15A/MIR16-1 is a driver of multiple myeloma proliferation and disease progression [0.03%]
MIR15A/MIR16-1单体性丢失是多发性骨髓瘤增殖和疾病进展的驱动因素
Marta Chesi,Caleb K Stein,Victoria M Garbitt et al.
Marta Chesi et al.
The most common genetic abnormality in multiple myeloma (MM) is the deletion of chromosome 13, seen in almost half of newly diagnosed patients. Unlike chronic lymphocytic leukemia, where a recurrent minimally deleted region including MIR15A...
Apolipoprotein C2 - CD36 Promotes Leukemia Growth and Presents a Targetable Axis in Acute Myeloid Leukemia [0.03%]
载脂蛋白C2-CD36促进白血病生长，并呈现了急性髓样白血病的可药靶点轴
Tian Zhang,Jiawen Yang,Vijaya P Vaikari et al.
Tian Zhang et al.
Acute myeloid leukemia (AML) is a devastating hematologic malignancy that affects the hematopoietic stem cells. The 5-year overall survival (OS) of patients with AML is less than 30%, highlighting the urgent need to identify new therapeutic...
Combinatorial ETS1-dependent control of oncogenic NOTCH1 enhancers in T-cell leukemia [0.03%]
T细胞白血病中原癌NOTCH1增强子的组合ETS1依赖性调控
Anna C McCarter,Giusy Della Gatta,Ashley Melnick et al.
Anna C McCarter et al.
Notch activation is highly prevalent among cancers, in particular T-cell acute lymphoblastic leukemia (T-ALL). However, the use of pan-Notch inhibitors to treat cancers has been hampered by adverse effects, particularly intestinal toxicitie...
Cytotoxic Therapy-Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms [0.03%]
细胞毒性治疗对造血和骨髓基质细胞的促进治疗相关髓系肿瘤的影响
Angela Stoddart,Jianghong Wang,Anthony A Fernald et al.
Angela Stoddart et al.
Therapy-related myeloid neoplasms (t-MNs) following treatment with alkylating agents are characterized by a del(5q), complex karyotypes, alterations of TP53, and a dismal prognosis. To decipher the molecular pathway(s) leading to the pathog...
Gene Expression Profiling of Mediastinal Gray Zone Lymphoma and Its Relationship to Primary Mediastinal B-cell Lymphoma and Classical Hodgkin Lymphoma [0.03%]
纵隔灰区淋巴瘤的基因表达特征及其与原发纵隔B细胞淋巴瘤和经典霍奇金淋巴瘤的关系
Stefania Pittaluga,Alina Nicolae,George W Wright et al.
Stefania Pittaluga et al.
Mediastinal gray zone lymphoma (MGZL) has immunopathologic features between classical Hodgkin lymphoma (cHL) and primary mediastinal thymic B-cell lymphoma (PMBL), leading to uncertainty regarding its biological relationship to these entiti...
Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia [0.03%]
复发性儿童急性淋巴细胞白血病的突变景观及克隆进化模式
Esmé Waanders,Zhaohui Gu,Stephanie M Dobson et al.
Esmé Waanders et al.
Relapse of acute lymphoblastic leukemia (ALL) remains a leading cause of childhood death. Prior studies have shown clonal mutations at relapse often arise from relapse-fated subclones that exist at diagnosis. However, the genomic landscape,...