Hyaluronan Inhibition as a Therapeutic Target for Diabetic Kidney Disease: What Is Next? [0.03%]
透明质酸抑制作为糖尿病肾脏疾病治疗靶点的前景及挑战
Loay Salman,Laisel Martinez,Geovani Faddoul et al.
Loay Salman et al.
Diabetic kidney disease (DKD) is the leading cause of CKD and ESKD in the United States and worldwide. Pharmacotherapy and lifestyle modifications for glycemia, dyslipidemia, and BP control have shown success in slowing the progression of D...
Decay-Accelerating Factor Restrains Complement Activation and Delays Progression of Murine cBSA-Induced Membranous Nephropathy [0.03%]
衰加速因子限制补体活化并延缓小鼠cBSA诱导的膜性肾病的发展
Kelly L Budge,Alberto Verlato,Sofia Bin et al.
Kelly L Budge et al.
Key Points: In a murine model of cationic bovine serum albumin (cBSA)–induced membranous nephropathy (MN), complement regulator decay-accelerating factor is upregulated and restrains complement activation.Studies using ...
Patient Perspectives of Skeletal Muscle Cramping in Dialysis: A Focus Group Study [0.03%]
透析患者的肌肉痉挛体验：一焦点团体研究
Amanda Grandinetti,Tandrea S Hilliard-Boone,Kenneth R Wilund et al.
Amanda Grandinetti et al.
Key Points: This first step demonstrated content validity for a patient-reported outcome measure for skeletal muscle cramping in dialysis.This work lays the foundation for developing a patient-reported outcome measure fo...
Targeted Transcriptional Analysis of IgA Vasculitis, IgA Nephropathy, and IgA-Dominant Infection-Related Glomerulonephritis Reveals Both Distinct and Overlapping Immune Signatures [0.03%]
靶向转录分析IgA血管炎、IgA肾病和以IgA为主的感染相关性肾小球肾炎的特异性和重叠免疫表型
Vanderlene L Kung,Rupali Avasare,Marcia A Friedman et al.
Vanderlene L Kung et al.
Key Points: Skin IL-9, calprotectin, and KIR gene expression may be predictive of subsequent kidney involvement in patients with IgAV.Histologically similar patients with IgAN, IgAV, and IgA-IRGN can be distinguished by ...
Megan L Baker,Lloyd G Cantley
Megan L Baker
The high-capacity vessels of the lymphatic system drain extravasated fluid and macromolecules from nearly every part of the body. However, far from merely a passive conduit for fluid removal, the lymphatic system also plays a critical and a...
Clinical Relevance of Computationally Derived Attributes of Peritubular Capillaries from Kidney Biopsies [0.03%]
计算获得的肾活检系膜毛细血管属性的临床意义
Yijiang Chen,Jarcy Zee,Andrew R Janowczyk et al.
Yijiang Chen et al.
Key Points: Computational image analysis allows for the extraction of new information from whole-slide images with potential clinical relevance.Peritubular capillary (PTC) density is decreased in areas of interstitial fi...
Clinical Profiles and Patterns of Kidney Disease Progression in C3 Glomerulopathy [0.03%]
C3肾小球病的临床特点和疾病进展模式
Fernando Caravaca-Fontán,Teresa Cavero,Montserrat Díaz-Encarnación et al.
Fernando Caravaca-Fontán et al.
Key Points: Kidney survival in C3 glomerulopathy is significantly higher in patients with a disease chronicity score
Catarina Mateus,Pedro Luís,Rita Birne
Catarina Mateus
Sonali Batta,Allie Preston,Lindsay Bicknell
Sonali Batta
Zinc Deficiency: A Potential Hidden Driver of the Detrimental Cycle of Chronic Kidney Disease and Hypertension [0.03%]
锌缺乏：慢性肾脏病和高血压恶性循环的潜在驱动因素
Adaku C Ume,Tara-Yesomi Wenegieme,Danielle N Adams et al.
Adaku C Ume et al.
Globally, over 103 million individuals are afflicted by CKD, a silent killer claiming the lives of 1.2 million people annually. CKD is characterized by five progressive stages, in which dialysis and kidney transplant are life-saving routes ...