Lindsey S Keo,Josef K Suba,Nhat M Pham et al.
Lindsey S Keo et al.
Background: Dialysis may deplete the body of valuable solutes. We previously found that the diet-derived antioxidant ergothioneine was markedly depleted in hemodialysis (HD) patients. Standard peritoneal dialysis (PD) pre...
Association of Podometric Parameters with the Oxford MEST-C Score and Pre-Treatment eGFR Slope in Patients with IgA Nephropathy [0.03%]
podometric参数与IgA肾病患者Oxford MEST-C评分和治疗前eGFR斜率的相关性
Shoko Ochiai,Masao Kikuchi,Koichi Kaikita et al.
Shoko Ochiai et al.
Background: Immunoglobulin A nephropathy is the most prevalent primary glomerular disease worldwide; however, its heterogenous clinical course complicates prognostic prediction. Podometrics, a quantitative assessment of p...
VO2Peak: The Emerging Endpoint For Cardiovascular Outcome Trials in Nephrology [0.03%]
VO2 Peak：肾脏病心血管结局试验的新终点指标
Kenneth Lim,Monique Campos,Sharon Moe
Kenneth Lim
Cardiovascular outcome trials are challenging to conduct in patients with CKD. Despite this, well-designed randomized controlled trials are critical to inform optimal management strategies and improve clinical care. Unfortunately, many card...
The Spatially Resolved Kidney Transcriptome Signatures in Rat Models of Trauma-Induced Acute Kidney Injury [0.03%]
基于创伤性急性肾损伤大鼠模型的空间分辨肾脏转录组信号通路分析
Pierre Isnard,Elisabeth Laemmel,Thibault Martinez et al.
Pierre Isnard et al.
Background: Trauma is a leading global cause of death, and acute kidney injury (AKI) significantly worsens outcomes. Hemorrhagic shock (HS) and rhabdomyolysis (RM) are major contributors, yet their individual and combined...
Facilitators and Barriers to Patient Enrollment in the AV Access Trial of Vascular Access Outcomes: A Qualitative Study [0.03%]
血液透析通路结局血管访问研究患者招募促进因素和阻碍因素：定性研究
Dipal M Patel,Allison M Chandler,Ashley E Strahley et al.
Dipal M Patel et al.
Background: People with kidney failure on chronic hemodialysis (HD) require sustainable vascular access. The AV Access trial is a randomized controlled trial comparing clinical and patient-reported outcomes in adults ≥ 6...
Biomarkers of Kidney Health and Dual Trajectories of Cognitive and Physical Function in Older Adults: Health Aging and Body Composition Study Findings [0.03%]
肾脏健康生物标志物与老年人认知功能和物理功能双重轨迹：来自身体成分与健康老龄化研究的发现
Aman Shrestha,Chixiang Chen,Stephen L Seliger et al.
Aman Shrestha et al.
Background: Kidney disease contributes to both cognitive and physical decline; whether kidney health biomarkers relate to declining cognitive and physical performance separately and/or together is unknown. ...
Christopher Y Chen,Mohamad Hadla,Ibrahim Khambati et al.
Christopher Y Chen et al.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder and a leading monogenic cause of kidney failure. Reduction or loss of polycystin-1 (PC1) and polycystin-2 (PC2) function disrupts ciliary calc...
Targeting αvβ8 Integrin with Monoclonal Antibody MEDI8367 Prevents Fibrosis in Preclinical Models of CKD [0.03%]
抗αvβ8单克隆抗体MEDI8367可预防慢性肾脏病前期模型中纤维化的发展
Elena Liarte Marin,Asha Seth,Lihuan Liang et al.
Elena Liarte Marin et al.
Background: CKD is a global health issue exacerbated by the rising prevalence of diabetes and obesity. Renal fibrosis, characterized by the accumulation of extracellular matrix proteins, is a critical factor in CKD progre...
Lactulose, a Disaccharide Prebiotic, Improves the Gut-Kidney Axis via Enhancement of Akkermansia Muciniphila Production [0.03%]
双糖益生元乳果糖通过增加黏液阿克曼氏菌的产生来改善肠-肾轴失调
Miyu Sueyoshi,Hiroshi Watanabe,Moritaka Goto et al.
Miyu Sueyoshi et al.
Background: Recently, we reported that lactulose, a synthetic disaccharide used to treat chronic constipation, improved the gut-renal axis in mice with adenine-induced CKD. However, the underlying mechanism remains unclea...
Physiological Normothermic Perfusion Enhances Kidney Preservation Versus the Established UK Normothermic Machine Perfusion Assessment Protocol [0.03%]
生理学常温灌注增强肾脏保存优于英国 established uk normothermic machine perfusion assessment protocol 常温机械灌注评估协议
John P Stone,William Norton,William R Cowey et al.
John P Stone et al.
Background: Hypothermic donor kidney preservation contributes to graft injury, leading to substantial discard rates and peri-transplant nephron loss. Normothermic machine perfusion may offer superior preservation, but cur...