Perspective on Fertility Topics in Autosomal Dominant Polycystic Kidney Disease [0.03%]
常染色体显性多囊肾病的生育话题透视
Sreyoshi Alam,Maria L Gonzalez Suarez
Sreyoshi Alam
Angiotensin Receptor and Neprilysin Inhibitors in CKD: Opportunity or Concern? [0.03%]
在慢性肾脏病中，血管紧张素受体和脑啡肽酶抑制剂是机会还是隐患？
Antonio De Pascalis,Alessandro Tomassetti,Daniele Vetrano et al.
Antonio De Pascalis et al.
Combined inhibition of neprilysin and the angiotensin II receptor through Angiotensin Receptor-Neprilysin inhibitors (ARNI) has transformed heart failure management and is garnering increasing attention in nephrology. This article explores ...
Dapagliflozin Reduces Kidney Inflammation in Alport Syndrome by Inhibiting the Stimulator of Interferon Genes Pathway in Renal Tubular Epithelial Cells [0.03%]
达格列净通过抑制肾小管上皮细胞中干扰素基因刺激物通路减少Alport综合征肾脏炎症
Qimin Zheng,Yafei Zhao,Yuanmeng Jin et al.
Qimin Zheng et al.
Background: Alport syndrome (AS) is a hereditary kidney disease caused by COL4A3/4/5 mutations that lack of effective treatments. Sodium-Glucose Co-Transporter 2 inhibitors (SGLT2i) have demonstrated renal and cardiovascu...
Jamie Kane,Sreenivasulu Kilari,Alaura Lemieux et al.
Jamie Kane et al.
Background: Hemodialysis therapy for end-stage kidney disease (ESKD) requires suitable vascular access, most commonly the arteriovenous fistula (AVF). Forty percent of AVFs fail within one year, leading to morbidity and c...
The Renal miRNA Expression Profile of Pkd1RC/RC Mice Changes Longitudinally with the Progression of the Disease [0.03%]
多囊肾1型基因杂合敲除小鼠肾脏疾病进程中的纵向miRNA表达谱变化
Nalin Sharma,Jamie Zheng,Yahya Alsawaf et al.
Nalin Sharma et al.
Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive development and enlargement of bilateral kidney cysts, which often leads to kidney failure. This study comprehensively c...
Transforming the Venous Blood Gas to the Arterial Blood Gas from Concurrent Measurements [0.03%]
基于同步测量转换静脉血气至动脉血气研究
Daniel Batlle,Romy Fischer,Luise Hassler et al.
Daniel Batlle et al.
Background: Arterial blood gas (ABG) analysis remains the gold standard for diagnosis and management of acid-base disorders. Obtaining arterial blood through arterial puncture, however, is cumbersome, at times difficult a...
Jacqueline Soraru,Andrew J Mallett,Hugh McCarthy et al.
Jacqueline Soraru et al.
Genomic investigation is playing an increasing role in the management of cystic kidney diseases, reflecting a broader shift towards precision medicine in Nephrology. Recent updates to the KDIGO Clinical Practice Guideline emphasize diagnost...
A Western Diet High in Phosphate Primes the Development of the CKD-Mineral Bone Disorder in an Alport Syndrome Model [0.03%]
高磷西方饮食加速Alport综合征肾小球疾病的进展及矿物质骨病的形成
Matthew J Williams,Hiral M Patel,Carley B Halling et al.
Matthew J Williams et al.
Background: Chronic kidney disease - mineral bone disorder (CKD-MBD) is a syndrome that contributes to cardiovascular mortality. We have shown that CKD decreases cardiac mitochondrial function independent of vascular dise...
LaMorgan Smith
LaMorgan Smith
Non-Coding RNAs as Targets of Acute Kidney Injury Therapy: Ready for Primetime? [0.03%]
非编码RNA会成为急性肾损伤治疗的新靶标吗？
Zhiwen Liu,Ying Fu,Juan Cai et al.
Zhiwen Liu et al.
AKI is a common clinical syndrome characterized by its complex pathophysiology and lack of effective therapeutic options, resulting in significantly increased mortality rates and a higher risk of progression to chronic kidney disease. In re...