The Effect of a Single Dose of Thiamine on Oxygen Consumption in Patients Requiring Mechanical Ventilation for Acute Illness: A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial [0.03%]
单剂量维生素B1对急性病机械通气患者耗氧量的影响：一项二期随机双盲安慰剂对照试验
Katherine M Berg,Anne V Grossestreuer,Lars W Andersen et al.
Katherine M Berg et al.
Lower oxygen consumption is associated with worse survival in septic shock and in other forms of critical illness. No treatment that increases oxygen extraction, a key determinant of oxygen consumption, has been found. Thiamine is required ...
Efficacy and Safety of Vilobelimab (IFX-1), a Novel Monoclonal Anti-C5a Antibody, in Patients With Early Severe Sepsis or Septic Shock-A Randomized, Placebo-Controlled, Double-Blind, Multicenter, Phase IIa Trial (SCIENS Study) [0.03%]
Vilobelimab（IFX-1）是一种新型的单克隆抗C5a抗体，在早期严重脓毒症或脓毒性休克患者中的有效性和安全性-一项随机、安慰剂对照、双盲、多中心、IIa期试验(SCIENS研究)
Michael Bauer,Andreas Weyland,Gernot Marx et al.
Michael Bauer et al.
Anaphylatoxin C5a, a proinflammatory complement split product, plays a central role in mediating organ dysfunction. Objectives: This phase II clinical tri...
Impact of a Procalcitonin-Based Protocol on Antibiotic Exposure and Costs in Critically Ill Patients [0.03%]
基于降钙素原的方案对重症患者抗生素暴露和费用的影响
Jarva Chow,Talar W Markossian,Fritzie S Albarillo et al.
Jarva Chow et al.
To examine the impact before and after adoption of a procalcitonin-based protocol to guide sepsis management has on antibiotic use, care costs, and outcomes of critically ill patients. ...
Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination [0.03%]
BNT162b2新型冠状病毐mRNA疫苗接种后的多系统炎症和器官功能障碍
Benjamin Kahn,Sokratis A Apostolidis,Vatsal Bhatt et al.
Benjamin Kahn et al.
The U.S. Food and Drug Administration has to date granted approval or emergency use authorization to three vaccines against severe acute respiratory syndrome coronavirus 2 and coronavirus disease 2019. In clinical trials and real-use observ...
Identification of Aggravation-Predicting Gene Polymorphisms in Coronavirus Disease 2019 Patients Using a Candidate Gene Approach Associated With Multiple Phase Pathogenesis: A Study in a Japanese City of 1 Million People [0.03%]
使用与多阶段发病机制相关的候选基因方法识别冠状病毒疾病2019患者病情加重预测的基因多态性：一项针对一百万人口日本城市的的研究
Naoki Tanimine,Daisuke Takei,Naohumi Tsukiyama et al.
Naoki Tanimine et al.
The pathology caused by the coronavirus disease 2019 is mediated by host-mediated lung inflammation, driving severity, and mortality. Polymorphisms in genes encoding host inflammation and immune-related molecules may be associated with the ...
The Effect of Chaplain Patient Navigators and Multidisciplinary Family Meetings on Patient Outcomes in the ICU: The Critical Care Collaboration and Communication Project [0.03%]
精神科医护人员和多学科家庭会议对ICU患者结果的影响：危重症关怀沟通合作项目
Fahid Alghanim,Muhammad Furqan,Laura Prichett et al.
Fahid Alghanim et al.
Objectives: To assess the effectiveness of a chaplain patient navigator in improving outcomes and reducing costs in the ICU setting. Design: ...
Queensland Pediatric Sepsis Breakthrough Collaborative: Multicenter Observational Study to Evaluate the Implementation of a Pediatric Sepsis Pathway Within the Emergency Department [0.03%]
昆士兰儿科脓毒症突破协作：多中心观察研究评估急诊科内实施儿科脓毒症路径的情况
Amanda Harley,Paula Lister,Patricia Gilholm et al.
Amanda Harley et al.
Objectives: To evaluate the implementation of a pediatric sepsis pathway in the emergency department as part of a statewide quality improvement initiative in Queensland, Australia. ...
Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis [0.03%]
血清可检测ADAMTS-1与儿童脓毒症不良预后相关
Navin P Boeddha,Gertjan J Driessen,Nienke N Hagedoorn et al.
Navin P Boeddha et al.
Importance: A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 is hypothesized to play a role in the pathogenesis of invasive infection, but studies in sepsis are lacking. ...
Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study [0.03%]
国际队列研究：机械通气的冠状病毒疾病2019患者住院28天死亡率评估
Gianluigi Li Bassi,Jacky Y Suen,Nicole White et al.
Gianluigi Li Bassi et al.
Factors associated with mortality in coronavirus disease 2019 patients on invasive mechanical ventilation are still not fully elucidated. Objectives: To i...
Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis [0.03%]
具有潜在肿瘤诊断的重症儿童出血的流行病学研究
Juliana Romano,Mario Martinez,Julie Levasseur et al.
Juliana Romano et al.
Objectives: Critically ill children with malignancy have significant risk of bleeding but the exact epidemiology is unknown. We sought to describe severe bleeding events and associated risk factors in critically ill pedia...