Sepsis and the Heart: In the Quest for Noninvasive Pressure-Volume Loops at the Bedside [0.03%]
脓毒症与心脏：寻找床旁无创压力容积环路
Pedro D Salinas,Jon Barnett,Siddharth Dugar
Pedro D Salinas
Background: Sepsis-induced cardiomyopathy (SICM) is prevalent yet remains difficult to diagnose using conventional echocardiography primarily due to its dependence on loading conditions, the dynamic nature of sepsis, and ...
Detecting Pain Correlates With Recovery in Acute Brain Injury Patients With Disorders of Consciousness [0.03%]
急性脑损伤意识障碍患者疼痛与恢复的相关性检测研究
Julia Houshmand,Brian Manolovitz,Kelsey E Ladd et al.
Julia Houshmand et al.
Objectives: To evaluate pain as measured by the critical care pain observation tool (CPOT) and its potential as a biomarker for recovery in acute brain injury (ABI) patients with disorders of consciousness (DoC). ...
Observational Study
Critical care explorations. 2025 Sep 24;7(10):e1323. DOI:10.1097/CCE.0000000000001323 2025
Methods of Adverse Event Detection in Intensive Care: A Systematic Review [0.03%]
重症监护中不良事件检测方法的系统评价
Jay Gorman,Oleksa Rewa,Janice Kung et al.
Jay Gorman et al.
Objective: The objective of this systematic review was to characterize adverse event detection methods in the ICU setting, including neonatal, pediatric, and adult ICUs, to summarize the evidence of their performance char...
Polymyxin B Hemoperfusion for Patients With Septic Shock Requiring High-Dose Norepinephrine: A Multicenter Prospective Cohort Study [0.03%]
用于大剂量去甲肾上腺素治疗的脓毒性休克患者的多黏菌素B血液灌注：一项前瞻性队列研究
Yu Kawazoe,Kyohei Miyamoto,Noriko Miyagawa et al.
Yu Kawazoe et al.
Importance: Polymyxin B hemoperfusion (PMX-HP) is a potential therapeutic option for sepsis; however, its clinical effects remain unclear. Objective: ...
Multicenter Study
Critical care explorations. 2025 Sep 22;7(10):e1320. DOI:10.1097/CCE.0000000000001320 2025
Two Physiologic Latent Classes of Acute Hypoxemic Respiratory Failure in Sepsis Are Distinguished by Lung Mechanics and Gas Exchange [0.03%]
感染性休克中由肺力学和气体交换区分的急性缺氧性呼吸衰竭两种生理隐匿类型
Rachel M Bennett,Kaitlyn C Housel,Tiffanie K Jones et al.
Rachel M Bennett et al.
Objectives: Physiologic subtypes of acute hypoxemic respiratory failure (AHRF) may confer a differential response to treatments, particularly therapeutic strategies that are specific to pulmonary organ failure. We sought ...
Predictors of Anemia Intolerance for Real-Time Transfusion Decision-Making During Resuscitation of Trauma Subjects: A Machine Learning Approach Using Heart Rate Variability [0.03%]
基于心率变异性运用机器学习方法预测创伤患者复苏过程中实时输血决策的贫血耐受指标
Mathangi Gopalakrishnan,Jie Chen,Rahul Goyal et al.
Mathangi Gopalakrishnan et al.
Objectives: RBC transfusion in anemic patients with sustainable tolerance may cause harm, emphasizing the need for reliable metrics that quantify adequacy (oxygen delivery ≥ demand) and sustainability (oxygen delivery re...
Evaluating the Safety of Current Intraosseous Needles and the Potential for Age-Based Guidance Using a Large-Scale Pediatric CT/MRI Imaging Study [0.03%]
基于年龄的骨内针安全性的影像学研究指导的潜力评估项目
Dilshan Rajan,Anuk Dias,Shaliny Jadhav et al.
Dilshan Rajan et al.
Objectives: To use 3D imaging modalities to obtain precise measurements of the proximal tibia in pediatric patients and assess the safety of current intraosseous needle lengths (15 and 25 mm). ...
Comparative Effectiveness of Less vs. More Frequent Hydrocortisone Dosing in Septic Shock [0.03%]
不同频率氢化可的松剂量在休克中的疗效比较研究
Alan Hao,Tianshi David Wu,Keegan Collins et al.
Alan Hao et al.
Objectives: Guidelines recommend hydrocortisone as an adjunctive treatment in septic shock, but the optimal dosing regimen is unknown. A national shortage of hydrocortisone in 2023 prompted a change in institutional pract...
Comparative Study
Critical care explorations. 2025 Sep 15;7(9):e1316. DOI:10.1097/CCE.0000000000001316 2025
Fast Acute Sedation at Intensive Care vs. High-Dose IV Anti-seizure Medication for Treatment of Non-convulsive Status Epilepticus: A Randomized, Multicenter Trial [0.03%]
快速镇静与大剂量抗癫痫药物治疗非惊厥性持续癫痫状态的疗效比较：一项多中心随机对照试验
Camilla Dyremose Cornwall,Henning Piilgaard,Thorbjørn Søndergaard Engedal et al.
Camilla Dyremose Cornwall et al.
Background: The management of refractory status epilepticus (SE) remains an area of low evidence with varying management strategies. Treatment in the ICU is often postponed due to potential complications from sedation, an...
Dynamic Measures of Fluid Responsiveness to Guide Resuscitation in Patients With Sepsis and Septic Shock: A Systematic Review and Meta-Analysis [0.03%]
用于指导脓毒症和脓毒性休克患者复苏的液体反应性动态监测措施的系统评价和meta分析
Jocelyn Wang,Leann Marie Blake,Nicolas Orozco et al.
Jocelyn Wang et al.
Objective: To determine the impact of using dynamic measures of fluid responsiveness in guiding the resuscitation of adult patients with sepsis and septic shock. ...