The Vigilance Gradient: Nine Years of Adverse Event Trends in Pediatric Critical Care [0.03%]
警惕渐变：儿科重症监护不良事件九年的变化趋势
Devika Singh,Michael R Miller,Maitray A Patel et al.
Devika Singh et al.
Objectives: To examine 11-year trends in adverse events (AEs) in a pediatric critical care unit (PCCU), assess the impact of the COVID-19 pandemic on patient safety, and evaluate associations between patient acuity and AE...
Observational Study
Critical care explorations. 2026 Apr 24;8(5):e1407. DOI:10.1097/CCE.0000000000001407 2026
Ketamine for Analgosedation in Critically Ill Mechanically Ventilated Children: A Systematic Review and Meta-Analysis [0.03%]
氯胺酮在儿童重症患者镇静镇痛中的应用：系统评价和.meta.分析
David J Zorko,Domi Zou,Sameer Sharif et al.
David J Zorko et al.
Objectives: We conducted a systematic review and meta-analysis to compare continuous ketamine infusion to other analgosedatives in critically ill children receiving invasive mechanical ventilation (IMV). ...
Real-Time Evaluation of a Large Language Model for Clinical Practice Guideline Development [0.03%]
临床实践指南开发的大规模语言模型的实时评估
Brian L Erstad
Brian L Erstad
Background: The purpose of this study was to evaluate the capability of a large language model (LLM) for performing each of the steps of clinical practice guideline development from framing a healthcare question to creati...
Geofrey Bahati,Wellars Niragire,Faustin Niyonshuti et al.
Geofrey Bahati et al.
Importance: Survivorship after critical illness in low-resource settings is inadequately characterized. Objectives: To assess 90-day mo...
Electroencephalogram Monitoring in Critical Care: Multicenter Analysis of Timing, Duration, and Readmissions [0.03%]
重症监护下脑电图监测的时机、时长及再入院的多中心分析研究
Alexandra-Maria Tăuțan,Marjan Sarami,Shadi Sartipi et al.
Alexandra-Maria Tăuțan et al.
Importance: Gaining insights into acute and critical care electroencephalogram (EEG) practice patterns can enable more efficient resource utilization without compromising care quality. ...
Multicenter Study
Critical care explorations. 2026 Apr 22;8(4):e1402. DOI:10.1097/CCE.0000000000001402 2026
Sympathomimetic Overdose With Lisdexamfetamine in a Pediatric Patient Resulting in Stress Cardiomyopathy-A Case Report [0.03%]
一例利他普胺药物中毒致应激性心肌病的病例报告
Hailey Guertin,Rhiannan Pinnell,Robert Chen et al.
Hailey Guertin et al.
Background: Sympathomimetic overdoses, as seen in amphetamine ingestions, are known to have cardiac effects ranging from tachycardia and hypertension to coronary vasospasm and myocardial infarction. Stress cardiomyopathy ...
Comparing Clinical Outcomes in Cardiac Surgical Patients Who Receive Sugammadex Versus Placebo: A Prospective Randomized Blinded Controlled Trial [0.03%]
sugammadex与安慰剂在心脏外科手术患者中临床疗效的对比：前瞻性随机盲法对照试验
Steven B Greenberg,Noah Ben-Isvy,Andrew R Locke et al.
Steven B Greenberg et al.
Objectives: To compare the difference in the number of cardiopulmonary bypass surgical patients who receive sugammadex vs. placebo and who meet the Society of Thoracic Surgery early extubation quality benchmark. ...
Randomized Controlled Trial
Critical care explorations. 2026 Apr 22;8(4):e1406. DOI:10.1097/CCE.0000000000001406 2026
Performance of Thromboelastography 6s Difference in Reaction Time Between Heparinase-Free and Heparinase-Containing Channel for Detecting Subtherapeutic Unfractionated Heparin Anticoagulation in a Pediatric Cardiac ICU [0.03%]
不含肝素酶与含肝素酶通道反应时间差的血栓弹力图在儿科心脏ICU中检测未分馏肝素亚治疗剂量抗凝性能的研究
Keisuke Nishida,Yusaku Ito,Kota Nakajima et al.
Keisuke Nishida et al.
Objectives: In cases where anti-Xa activity is not routinely measurable, estimating heparin efficacy using the activated partial thromboplastin time (APTT) is challenging, and misestimation may risk bleeding or thrombotic...
Observational Study
Critical care explorations. 2026 Apr 22;8(4):e1400. DOI:10.1097/CCE.0000000000001400 2026
The Effects of Conservative Fluid Management and Active Deresuscitation on Markers of Tissue Perfusion, Kidney Injury, and Vascular Injury in Critically Ill Adults: A Secondary Analysis of the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) Trial [0.03%]
限制性液体管理及积极减容治疗对重症成人组织灌注、肾损伤和血管损伤标志物的影响：RESUCTION-2（RADAR-2）试验的二次分析结果
Ross R McMullan,Christopher McGrath,Neil Cody et al.
Ross R McMullan et al.
Objectives: Test the hypothesis that conservative fluid management with active deresuscitation would not adversely affect tissue perfusion or kidney injury and would be associated with reduced vascular injury compared wit...
Randomized Controlled Trial
Critical care explorations. 2026 Apr 22;8(4):e1404. DOI:10.1097/CCE.0000000000001404 2026
Machine Learning-Based Prediction of Critical Deterioration in the PICU [0.03%]
基于机器学习的PICU患者病情恶化的预测模型
Sanjiv D Mehta,Eamonn Tweedy,Victor M Ruiz et al.
Sanjiv D Mehta et al.
Background: Existing PICU early warning systems lack sufficient accuracy and timeliness for effective preparation. Machine learning approaches may improve prediction of critical deterioration events (CDEs), but their oper...