Fatal Triad of Subarachnoid Hemorrhage, Cervical Hematoma, and Upper Airway Obstruction in a Patient With Neurofibromatosis Type 1: A Case Report [0.03%]
1型神经纤维瘤病患者的蛛网膜下腔出血、颈椎血肿和上气道阻塞的致命三联征：病例报告
Maximilian Rühlmann,Matthias Gawlitza,Nazife Dinc et al.
Maximilian Rühlmann et al.
Background: Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder, characterized by neurocutaneous lesions. NF1 has a high degree of clinical variability, which can include multiple neoplasia as well as...
Personalized Fluid Management in Patients With Sepsis and Acute Kidney Injury: A Casual Machine Learning Approach [0.03%]
用于脓毒症和急性肾损伤患者的个性化液体管理：一种因果机器学习方法
Wonsuk Oh,Kullaya Takkavatakarn,Zainab Al-Taie et al.
Wonsuk Oh et al.
Importance: IV fluids are the cornerstone for management of acute kidney injury (AKI) after sepsis but can cause fluid overload. A restrictive fluid strategy may benefit some patients; however, identifying them is challen...
Pressure Support Ventilation in Neurosurgical Patients: Can We Safely Reduce Assistance? Evaluation of Neurosurgical Patients' Ventilation Distribution - The ENVISION Study [0.03%]
神经外科患者的气道管理压力支持通气研究：能否安全降低支持力度？基于ENVISION研究的神经外科患者通气分布评估
Vorakamol Phoophiboon,Antenor Rodrigues,Matthew Ko et al.
Vorakamol Phoophiboon et al.
Objectives: To identify the prevalence of over-assistance from mechanical ventilation (MV) and to assess whether reducing MV support could be done safely in neurosurgical ICU patients in terms of risk of under-assistance ...
Observational Study
Critical care explorations. 2025 Dec 3;7(12):e1347. DOI:10.1097/CCE.0000000000001347 2025
Artificial Intelligence-Based Predictive Modeling for Early Detection of Sepsis in Hospitalized Patients: A Systematic Review and Meta-Analysis [0.03%]
基于人工智能的预测模型在住院患者脓毒症早期检测中的系统评价和 meta 分析
Ghulam Husain Abbas,Palash Sen,Oviya Anjali Giri et al.
Ghulam Husain Abbas et al.
Objectives: This systematic review evaluates artificial intelligence (AI)-based predictive models developed for early sepsis detection in adult hospitalized patients. It explores model types, input features, validation st...
Urine Olfactomedin 4 Predicts Furosemide Response and Kidney Replacement Therapy in Critically Ill Children [0.03%]
尿液olfactomedin 4预测重症儿童呋塞米反应和肾脏替代治疗
Denise C Hasson,Imogen Clover-Brown,Diana Zepeda-Orozco et al.
Denise C Hasson et al.
Objectives: To test whether urine olfactomedin 4 (uOLFM4) can predict furosemide responsiveness in patients at high risk for acute kidney injury (AKI) early in the PICU course. A secondary outcome was prediction of kidney...
Observational Study
Critical care explorations. 2025 Dec 3;7(12):e1356. DOI:10.1097/CCE.0000000000001356 2025
The POETIC (PrOcess Evaluation of Trials In Critical care) Framework: A Structured Approach for Designing and Conducting Process Evaluations in Critical Care Trials [0.03%]
POETIC（重症监护临床试验结果评价）框架：在重症监护试验中设计和开展过程评估的结构化方法
Lydia M Emerson,Daniel F McAuley,Bronagh Blackwood et al.
Lydia M Emerson et al.
Background: A process evaluation systematically examines how an intervention is delivered, including activities, procedures, and contextual factors influencing implementation. Existing process evaluation frameworks were p...
Long-Term Functional and Quality-of-Life Outcomes in Survivors of Refractory Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation [0.03%]
静脉动脉体外膜肺氧合治疗难治性心源性休克后患者长期功能及生活质量预后研究
Sofia Ortuno,Delphine Bachelet,Olivier Varnet et al.
Sofia Ortuno et al.
Importance: Long-term functional outcomes and health-related quality of life (HRQoL) in survivors of cardiogenic shock treated with venoarterial extracorporeal membrane oxygenation (ECMO) remain poorly understood. ...
Observational Study
Critical care explorations. 2025 Dec 2;7(12):e1359. DOI:10.1097/CCE.0000000000001359 2025
Fast, Accurate Assignment of Clinical Diagnoses From Patient Notes by a Large Language Model: Critical Pediatric Pneumonia as a Use Case [0.03%]
快速准确地使用大型语言模型从患者记录中分配临床诊断：以儿科重症肺炎为例
Blake Martin,Marisa Payan,Jaime LaVelle et al.
Blake Martin et al.
Objective: To determine the accuracy of a custom version of the generative pretrained transformer (GPT)-4o large language model (LLM) in identifying PICU admissions with vs. without bacterial pneumonia using clinical note...
Effect of Neuromuscular Electrical Stimulation for Older Critically Ill Patients in the ICU: A Randomized Controlled Trial [0.03%]
重症监护病房老年危重患者的神经肌肉电刺激疗效的随机对照试验
Kazuhiro Yokobatake,Hiroaki Kitaoka,Atsushi Morizane et al.
Kazuhiro Yokobatake et al.
Objectives: In the ICU, the optimal patient population for neuromuscular electrical stimulation (NMES) and the most appropriate evaluation tools remain unclear. This study aimed to assess whether combining early mobilizat...
Randomized Controlled Trial
Critical care explorations. 2025 Nov 25;7(12):e1345. DOI:10.1097/CCE.0000000000001345 2025
Ward-Based High-Flow Nasal Cannula Led by the Medical Emergency Team: A Pragmatic Model for Resource Stewardship [0.03%]
基于医疗紧急团队的病房高流量鼻导管吸氧治疗：一种实用的医疗资源管理模型
Imran Khalid,Basel Ghurm Alshehri,Raafey Imran et al.
Imran Khalid et al.
High-flow nasal cannula (HFNC) for acute hypoxemic respiratory failure is typically restricted to ICUs. We evaluated a ward-based, medical emergency team (MET)-supervised HFNC protocol (flow ≤ 40 L/min, Fio2 ≤ 0.40) with 2-/4-/8-hour nurs...