Circulating Short-Chain Fatty Acid Profile Predicts Functional Outcome After Moderate-to-Severe Traumatic Brain Injury [0.03%]
循环短链脂肪酸谱预测中重度创伤性脑损伤后的功能预后
Ori J Lieberman,Sanhita Nittala,Luisa Rojas-Valencia et al.
Ori J Lieberman et al.
Objectives: Short-chain fatty acids (SCFAs) are immunometabolites produced by the gut microbiome. In animal models, SCFAs affect traumatic brain injury (TBI) severity by modulating the immune response and serving as an en...
Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance [0.03%]
基于净流体和体重评估计算累计液体平衡的分歧
Finley J Shinnick,Denise C Hasson,Ulka Kothari et al.
Finley J Shinnick et al.
Objective: Although efforts have been made to standardize fluid balance calculations in the ICU, there is a limited understanding of how different calculation methods relate to one another across an ICU admission. We quan...
Observational Study
Critical care explorations. 2026 Jun 10;8(6):e1411. DOI:10.1097/CCE.0000000000001411 2026
Barriers and Facilitators to ICU Liberation Bundle Implementation and Compliance [0.03%]
ICU解放套餐的实施及遵从的障碍与促进因素
Payal K Gurnani,Erika L Setliff,Samer Abu-Sultaneh et al.
Payal K Gurnani et al.
Objectives: The ICU Liberation bundle is a framework to help translate the Pain, Agitation, Delirium, Immobility, and Sleep Guidelines into clinical practice. Bundle performance has been shown to improve short- and long-t...
Aerosol Delivery With a Vibrating Mesh Nebulizer Across Tidal Volume-Based Pediatric Invasive Ventilation Models: An In Vitro Evaluation [0.03%]
基于潮气量的儿科有创通气模型中振动网孔雾化器给药的体外评价
Shinya Miura,Yoshihiro Igarashi,Kenta Shono et al.
Shinya Miura et al.
Context: Despite the widespread use of vibrating mesh nebulizers (VMNs) for aerosol therapy during mechanical ventilation, there is limited pediatric evidence on how tidal volume (TV)-based ventilation models and commonly...
Process Analysis of Neonatal and Pediatric Respiratory Extracorporeal Membrane Oxygenation Referrals: An 8-Year Experience at a High-Volume Center [0.03%]
体外膜氧合转运及一高容量中心八年来的诊治流程分析经验总结：新生儿和儿童呼吸衰竭治疗
Anna C Dermatidis,Tom W Bayer,Verena Varnholt et al.
Anna C Dermatidis et al.
Objectives: To evaluate neonatal and pediatric extracorporeal membrane oxygenation (ECMO) referrals and transfers to a high-volume center and optimize the process of ECMO referrals and decision-making. ...
Artificial Liver Support Effectively Removes Immunosuppressive Bile Acids From Circulation in Patients With Severe Liver Failure: A Proof of Concept Study [0.03%]
人工肝支持系统有效清除重症肝衰患者循环中的免疫抑制型胆酸：概念验证性研究
Julia Leonhardt,Hartmut H-J Schmidt,Sebastian Koball et al.
Julia Leonhardt et al.
Objective: Bile acids that induce immunosuppression through activation of the Takeda G protein-coupled receptor 5 (TGR5) have recently been identified in the circulation of patients with liver failure and sepsis. These bi...
Early Prone Positioning After Acute Type A Aortic Dissection Surgery for Moderate-to-Severe Acute Respiratory Distress Syndrome Is Safe and Shortens Duration of Mechanical Ventilation [0.03%]
急性A型主动脉夹层术后中重度急性呼吸窘迫综合征患者早期俯卧位安全且能缩短机械通气时间
Huilong Chen,Chuang Wu,Yunwei Chen et al.
Huilong Chen et al.
Importance: Evidence for prone positioning in post-cardiac surgery acute respiratory distress syndrome (ARDS), especially after acute type A aortic dissection (ATAAD) repair, is extremely limited. Clinicians remain uncert...
A Novel Screen-Based Virtual Reality Tool for Teaching Brain Death Determination: A Pilot Study of the Virtual Reality Brain Death Determination Tool [0.03%]
一种基于屏幕的虚拟现实工具在脑死亡判定教学中的应用研究：虚拟现实脑死亡判定工具试点实验
Mikel S Ehntholt,Patricia A Mulvania,Theresa A Daly et al.
Mikel S Ehntholt et al.
Objective: To assess physician acceptance of a Virtual Reality Brain Death Determination Tool (VRBDDT) as an educational modality and its impact on physician knowledge and confidence in brain death determination and commu...
Linking the Virtual Pediatric System and Pediatric Hospital Information System Databases to Create Novel PICU Research Datasets [0.03%]
链接虚拟儿科系统和儿科医院信息系统数据库以创建新颖的PICU研究数据集
Brian F Flaherty,Seth Otto,Cody S Olsen et al.
Brian F Flaherty et al.
Background: Lack of a robust, national PICU database hinders epidemiologic and quasi-experimental research of PICU care. Combining the virtual pediatric system (VPS) and pediatric health information system (PHIS) database...
The Tip of the Iceberg: Pathway Biology Must Anchor the Next Generation of Critical Care Trials [0.03%]
冰山一角：通路生物学须成为下一代重症监护试验的基石
Logan R Van Nynatten,Douglas D Fraser,Tristan Look-Hong et al.
Logan R Van Nynatten et al.
Heterogeneity of treatment effect has yielded decades of negative critical care trials. Syndromic diagnoses like sepsis and acute respiratory distress syndrome mask distinct molecular programs that respond differently to the same interventi...