Vasopressin Initiation Timing and In-Hospital Mortality in Septic Shock: An Observational Study of Large Public Databases [0.03%]
大样本公共数据库中败血性休克患者抗利尿激素的使用时机与院内死亡率之间的观察性研究
Gretchen L Sacha,Abhijit Duggal,Anita J Reddy et al.
Gretchen L Sacha et al.
Importance: Vasopressin is used in one-third of patients with septic shock to augment hemodynamics and reduce overall catecholamine exposure. However, the optimal clinical context in which to initiate vasopressin is unkno...
Observational Study
Critical care explorations. 2025 Aug 22;7(9):e1284. DOI:10.1097/CCE.0000000000001284 2025
A Pilot Randomized Controlled Trial Assessing the Feasibility and Acceptability of Family-Partnered Delirium Prevention, Detection, and Management in Critically Ill Adults: The Activating Family Caregivers in the Identification Prevention and Management of Delirium (ACTIVATE) Study [0.03%]
家庭参与的危重症成人谵妄预防、检测和管理试点随机对照试验的可行性和接受度评估：激活家庭护理人员在识别、预防和管理谵妄（ACTIVATE）研究
Kirsten M Fiest,Karla D Krewulak,Bonnie G Sept et al.
Kirsten M Fiest et al.
Objectives background: Delirium remains frequently undetected by healthcare providers; partnering with family may be a novel way to identify and manage delirium. This study explores the feasibility of a family-administere...
Randomized Controlled Trial
Critical care explorations. 2025 Aug 22;7(9):e1287. DOI:10.1097/CCE.0000000000001287 2025
Soluble Fms-Like Tyrosine Kinase-1 Associates With Risk of Acute Respiratory Distress Syndrome and Mortality in Sepsis [0.03%]
可溶型Fms样酪氨酸激酶-1与脓毒症急性呼吸窘迫综合征风险及死亡率的相关性研究
Tiffanie K Jones,John P Reilly,Brian J Anderson et al.
Tiffanie K Jones et al.
Importance: The vascular endothelial growth factor (VEGF) signaling pathway is important in the pathogenesis of acute respiratory distress syndrome (ARDS) with supportive genetic and proteomic evidence. Genetic polymorphi...
Evaluation of Objective Sedation Monitoring Practices in Critically Ill Adult Patients: A Systematic Review and Meta-Analysis [0.03%]
成人重症患者客观镇静监测实践的评价：系统回顾和 meta 分析
Natalia Jaworska,Areej Hezam,Thérèse Poulin et al.
Natalia Jaworska et al.
Objectives: To conduct a systematic review and meta-analysis to determine if objective sedation monitoring practices reduce duration of mechanical ventilation and other clinical and healthcare utilization outcomes in crit...
Access to Limited Critical Care and Risk of Mortality in Rwanda: A Prospective Cohort Study [0.03%]
卢旺达重症监护有限导致的死亡风险：一项前瞻性队列研究
Alex Mezei,Donatien Hitayezu,Tyler Gilman et al.
Alex Mezei et al.
Importance: There is a large discrepancy between need and access to critical care in low- and middle-income countries. Little is known about what subgroups of patients are being prioritized for critical care. ...
Life-Supporting Treatment Limitations in Patients Who Die Within 48 Hours After ICU Admission: A French, Multicenter, Observational, Exploratory Study [0.03%]
一项法国多中心观察性探索性研究：ICU住院48小时之内死亡患者的抢救限度声明状况
Aurélie Nouvel,Pierre Leprovost,Charlotte Larrat et al.
Aurélie Nouvel et al.
Importance: The occurrence of death shortly after ICU admission raises concerns about the appropriateness of providing intensive care to frail patients-many of whom are subsequently subject to decisions to limit life-supp...
Observational Study
Critical care explorations. 2025 Aug 6;7(8):e1300. DOI:10.1097/CCE.0000000000001300 2025
The Novel Application of Surgiflo and Successful Hemostasis of Refractory Intrapulmonary Hemorrhage in Extracorporeal Membrane Oxygenation [0.03%]
Surgiflo新型应用成功用于体外膜肺氧合支持患者的顽固性支气管动静脉畸形破裂出血的肺内血肿止血治疗
Syed H Haq,Riley Pulver,Hoshimjon Begmatov et al.
Syed H Haq et al.
Background: Intrapulmonary hemorrhage (IPH) is a life-threatening condition associated with specific risk factors including prolonged mechanical ventilation, therapeutic anticoagulation, and notably, mechanical circulator...
Outcomes of Venovenous Extracorporeal Membrane Oxygenation for Pneumocystis jirovecii Pneumonia: A Multicenter Retrospective Case Series [0.03%]
静脉姑息性体外膜肺氧合治疗新型隐球菌肺炎的疗效：多中心回顾性病例系列研究
Aaron M Pulsipher,Kyle Henry,Holenarasipur R Vikram et al.
Aaron M Pulsipher et al.
Pneumocystis jirovecii pneumonia (PCP) is a life-threatening opportunistic infection increasingly recognized among non-HIV immunocompromised patients. In severe cases progressing to acute respiratory distress syndrome, venovenous extracorpo...
Multicenter Study
Critical care explorations. 2025 Aug 4;7(8):e1296. DOI:10.1097/CCE.0000000000001296 2025
Kirstin J Kooda,Julia Nelson,Sara E Ausman et al.
Kirstin J Kooda et al.
This study aimed to determine if extended infusion (EI; over > 3 hr) beta-lactam therapy increased IV access requirements compared with traditional dosing (TD; over 30 min). Eighty-six adult ICU patients treated with TD anti-pseudomonal bet...
Challenges Facing Developers of Diagnostic Tests for Sepsis: A Report From Sepsis Alliance and the Infection Management and Sepsis Collaborative Community [0.03%]
脓毒症诊断检测开发面临挑战：Sepsis联盟和感染管理与脓毒症协作社区报告
Michael T McCurdy,Timothy E Sweeney,Debra Foster et al.
Michael T McCurdy et al.
Objectives: To characterize regulatory and clinical adoption challenges to developing host-based sepsis diagnostics and to establish a common framework for stakeholders to work together toward potential solutions to these...