Progesterone for Traumatic Brain Injury, Experimental Clinical Treatment III Trial Revisited: Objective Classification of Traumatic Brain Injury With Brain Imaging Segmentation and Biomarker Levels [0.03%]
孕酮治疗创伤性脑损伤的实验性临床III期试验重新评估：基于脑影像分割和生物标志物水平的客观分类创伤性脑损伤
Scarlett Cheong,Rishabh Gupta,Sharada Kadaba Sridhar et al.
Scarlett Cheong et al.
Objective: This post hoc study of the Progesterone for Traumatic Brain Injury, Experimental Clinical Treatment (ProTECT) III trial investigates whether improving traumatic brain injury (TBI) classification, using serum bi...
Randomized Controlled Trial
Critical care explorations. 2025 Sep 5;7(9):e1306. DOI:10.1097/CCE.0000000000001306 2025
Organ Failure, Endotoxin Activity, and Mortality in Septic Shock [0.03%]
脓毒症休克患者器官功能衰竭与内毒素活性变化及其对病死率的影响
Luca Molinari,Mark A Tidswell,Ali Al-Khafaji et al.
Luca Molinari et al.
Importance: The relationship between endotoxin activity, organ failure, and mortality is not well understood. Objective: To test whethe...
Observational Study
Critical care explorations. 2025 Aug 28;7(9):e1308. DOI:10.1097/CCE.0000000000001308 2025
Inter-rater Agreement of Richmond Agitation Sedation Scale Assessments in Adult Patients Receiving Mechanical Ventilation in the ICU: A Cross-Sectional Study [0.03%]
RICU机械通气成人患者RASS评分的计分者间可靠度调查研究
Mikita Fuchita,Jack Pattee,David Le et al.
Mikita Fuchita et al.
Importance: Accurate and reliable sedation assessment is crucial to improving patient outcomes in the ICU. Objective: To evaluate the i...
Prior Use of Renin-Angiotensin System Inhibitors and Risk of Renal Replacement Therapy in Critically Ill Elderly Patients With Sepsis: A Population-Based Cohort Study [0.03%]
脓毒症重症老年患者肾素-血管紧张素系统抑制剂的使用对其肾脏替代治疗风险的影响：基于人群的队列研究
Victoria Otero Castro,Damon C Scales,Federico Angriman
Victoria Otero Castro
Objectives: We sought to estimate the association between chronic use of renin-angiotensin system inhibitors and acute kidney injury requiring renal replacement therapy in critically ill adult patients with sepsis. ...
Vasopressin Initiation Timing and In-Hospital Mortality in Septic Shock: An Observational Study of Large Public Databases [0.03%]
大样本公共数据库中败血性休克患者抗利尿激素的使用时机与院内死亡率之间的观察性研究
Gretchen L Sacha,Abhijit Duggal,Anita J Reddy et al.
Gretchen L Sacha et al.
Importance: Vasopressin is used in one-third of patients with septic shock to augment hemodynamics and reduce overall catecholamine exposure. However, the optimal clinical context in which to initiate vasopressin is unkno...
Observational Study
Critical care explorations. 2025 Aug 22;7(9):e1284. DOI:10.1097/CCE.0000000000001284 2025
A Pilot Randomized Controlled Trial Assessing the Feasibility and Acceptability of Family-Partnered Delirium Prevention, Detection, and Management in Critically Ill Adults: The Activating Family Caregivers in the Identification Prevention and Management of Delirium (ACTIVATE) Study [0.03%]
家庭参与的危重症成人谵妄预防、检测和管理试点随机对照试验的可行性和接受度评估：激活家庭护理人员在识别、预防和管理谵妄（ACTIVATE）研究
Kirsten M Fiest,Karla D Krewulak,Bonnie G Sept et al.
Kirsten M Fiest et al.
Objectives background: Delirium remains frequently undetected by healthcare providers; partnering with family may be a novel way to identify and manage delirium. This study explores the feasibility of a family-administere...
Randomized Controlled Trial
Critical care explorations. 2025 Aug 22;7(9):e1287. DOI:10.1097/CCE.0000000000001287 2025
Soluble Fms-Like Tyrosine Kinase-1 Associates With Risk of Acute Respiratory Distress Syndrome and Mortality in Sepsis [0.03%]
可溶型Fms样酪氨酸激酶-1与脓毒症急性呼吸窘迫综合征风险及死亡率的相关性研究
Tiffanie K Jones,John P Reilly,Brian J Anderson et al.
Tiffanie K Jones et al.
Importance: The vascular endothelial growth factor (VEGF) signaling pathway is important in the pathogenesis of acute respiratory distress syndrome (ARDS) with supportive genetic and proteomic evidence. Genetic polymorphi...
Evaluation of Objective Sedation Monitoring Practices in Critically Ill Adult Patients: A Systematic Review and Meta-Analysis [0.03%]
成人重症患者客观镇静监测实践的评价：系统回顾和 meta 分析
Natalia Jaworska,Areej Hezam,Thérèse Poulin et al.
Natalia Jaworska et al.
Objectives: To conduct a systematic review and meta-analysis to determine if objective sedation monitoring practices reduce duration of mechanical ventilation and other clinical and healthcare utilization outcomes in crit...
Access to Limited Critical Care and Risk of Mortality in Rwanda: A Prospective Cohort Study [0.03%]
卢旺达重症监护有限导致的死亡风险：一项前瞻性队列研究
Alex Mezei,Donatien Hitayezu,Tyler Gilman et al.
Alex Mezei et al.
Importance: There is a large discrepancy between need and access to critical care in low- and middle-income countries. Little is known about what subgroups of patients are being prioritized for critical care. ...
Life-Supporting Treatment Limitations in Patients Who Die Within 48 Hours After ICU Admission: A French, Multicenter, Observational, Exploratory Study [0.03%]
一项法国多中心观察性探索性研究：ICU住院48小时之内死亡患者的抢救限度声明状况
Aurélie Nouvel,Pierre Leprovost,Charlotte Larrat et al.
Aurélie Nouvel et al.
Importance: The occurrence of death shortly after ICU admission raises concerns about the appropriateness of providing intensive care to frail patients-many of whom are subsequently subject to decisions to limit life-supp...
Observational Study
Critical care explorations. 2025 Aug 6;7(8):e1300. DOI:10.1097/CCE.0000000000001300 2025