Ceragenin-Coated Endotracheal Tubes for the Reduction of Ventilator-Associated Pneumonia: A Prospective, Longitudinal, Crossover, Interrupted Time, Implementation Study (CEASE VAP Study) [0.03%]
John Muscedere,Patrick A Norman,Christine D&#x;Arsigney et al.
John Muscedere et al.
Objective: To evaluate the impact of Ceragenin-coated endotracheal tubes (CSA ETTs) on the incidence of ventilator-associated pneumonia (VAP) in critically ill adults and assess feasibility of conducting a multicenter stu...
Multicenter Study
Critical care explorations. 2026 Mar 20;8(4):e1382. DOI:10.1097/CCE.0000000000001382 2026
R Brandon Hunter,Satid Thammasitboon,Sreya Rahman et al.
R Brandon Hunter et al.
Objectives: To evaluate the feasibility of a large language model (LLM)-based chatbot for answering parental questions in the PICU and inform design of a randomized controlled trial (RCT). ...
Tocilizumab Efficacy Across Inflammatory Subphenotypes in COVID-19-Related Acute Respiratory Distress Syndrome [0.03%]
Daan F L Filippini,Jessica Khyali,Malou Janssen et al.
Daan F L Filippini et al.
Objectives: This study evaluated whether the established efficacy of tocilizumab, an interleukin-6 (IL-6) receptor antagonist, differs between the hypoinflammatory and hyperinflammatory subphenotypes. ...
Post-Acute Sequelae of COVID-19 Persist Over 3 Years in Acute Lung Injury/Acute Respiratory Distress Syndrome Survivors But Are Not Associated With Persistent Thromboinflammation or Endothelial Dysfunction [0.03%]
急性肺损伤/急性呼吸窘迫综合征幸存者的新冠肺炎后遗症在三年内持续存在，但与持续的血栓炎症或内皮功能障碍无关
Ansley E Jones,Zain Khan,Claire F McGroder et al.
Ansley E Jones et al.
Importance: Inflammation, endothelial dysfunction, and complement activation are associated with COVID-19 acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). ...
The Association of Iatrogenic Withdrawal With Opioid and Benzodiazepine Weaning in Children With Bronchiolitis: A Single-Center, Retrospective Cohort Study, 2012-2022 [0.03%]
2012-2022年儿科毛细支气管炎患者医源性戒断与阿片类和苯二氮卓类药物减量的关联：单中心回顾性队列研究
Alice Shanklin,Eduardo A Trujillo Rivera,Murray M Pollack et al.
Alice Shanklin et al.
Objectives: This study aimed to determine the decrease in opioid and benzodiazepine doses associated with the development of withdrawal in children. Setti...
Development and Psychometric Testing of the Optimizing Context in Assessing Sedation in ICU (OCEAN-ICU) Instrument to Optimize Sedation Use in Intensive Care [0.03%]
重症监护中优化镇静使用的OCEAN-ICU评估仪器的开发和心理测量测试
Leanne M Aitken,Ana Castro-Avila,Judith Dyson et al.
Leanne M Aitken et al.
Context: Sedation and pain management are core strategies used to manage discomfort, anxiety, and pain in intensive care; however, strategies to improve this practice are inconsistently implemented with differential effec...
Sameer Sharif,Kevin Wang,John Basmaji et al.
Sameer Sharif et al.
Objectives: To summarize the effectiveness of critical care ultrasonography (CCUS) in adult patients with cardiogenic shock vs. standard of care without CCUS on patient-relevant outcomes. ...
Lung and Venous Excess Ultrasound Correlation With Intracardiac Pressures Before and After Decongestion in Critically Ill Patients With Acute Decompensated Heart Failure [0.03%]
急性心力衰竭重症患者纠脱前后的肺静脉负荷超声与心内压力的相关性研究
Jose Victor Jimenez,Sukrit Narula,Santiago Callegari et al.
Jose Victor Jimenez et al.
Importance: Venous congestion contributes to multiple organ dysfunction and mortality in critically ill patients. The venous excess ultrasound (VExUS) and lung ultrasound scores have been shown to reflect cardiac filling ...
Observational Study
Critical care explorations. 2026 Mar 10;8(3):e1385. DOI:10.1097/CCE.0000000000001385 2026
Ultrasound Assessment of the Third Ventricle Diameter: Agreement With CT Results in the Pediatric Population [0.03%]
儿科人群超声测量第三脑室直径与CT结果的一致性评估
Safae Dehbi,Zhor Zeghari,Chaimae Es-Sebbani et al.
Safae Dehbi et al.
Objectives: To evaluate the agreement between transcranial ultrasound (TUS) and CT measurements of third ventricle diameter in critically ill children. De...
Observational Study
Critical care explorations. 2026 Mar 9;8(3):e1387. DOI:10.1097/CCE.0000000000001387 2026