Conor J R Scott,Silvia Caccia
Conor J R Scott
Summary: metaLoc combines existing tools for signal peptide, localisation, and transmembrane helices prediction from protein sequences into a workflow for rapid evaluation of protein datasets. By accepting both protein an...
Fuscan: a robust DNA fusion caller for targeted sequencing data in cancer diagnostics [0.03%]
Fuscan：一种用于癌症诊断中靶向测序数据的稳健型DNA融合检测器
Zhaoying Liu,Siyu Wang,Si Chen et al.
Zhaoying Liu et al.
Motivation: Gene fusions resulting from genomic structural variation in somatic cells have been increasingly identified as central events driving oncogenesis. Ultra-deep targeted sequencing of driver fusions informs thera...
Correction to: Pathogenicity patterns in cytochrome P450 family [0.03%]
Correction to: 酪氨酸蛋白磷酸酶家族成员PRL-1和PRL-2在肿瘤发生中的作用及机制研究——追溯PRLs从发现到临床应用的旅程
[This corrects the article DOI: 10.1093/bioadv/vbaf231.]. © The Author(s) 2026. Published by Oxford University Press.
Published Erratum
Bioinformatics advances. 2026 Jul 2;6(1):vbag161. DOI:10.1093/bioadv/vbag161 2026
Region-aware bridge modeling enables interpretable mesoscale representation of spatial transcriptomic tissue sections [0.03%]
地区感知桥建模能够对空间转录组学组织切片进行解释的中尺度表示
Seung-Hwan Kim
Seung-Hwan Kim
Motivation: Spatial transcriptomics maps tissue architecture at high resolution, but spot-level maps are difficult to compare across sections, whereas whole-section averages obscure regional organization. We developed reg...
Microbiome differential abundance methodologies to detect relevant taxa associated with chemotherapy toxicity rate in colorectal cancer [0.03%]
检测结直肠癌化疗毒性率相关的微生物差异丰度方法
Elsa Martín-De Arribas,Kelly Conde-Pérez,Pablo Aja-Macaya et al.
Elsa Martín-De Arribas et al.
Motivation: The interplay between microbial communities and treatment outcomes represents a promising area in pharmacomicrobiomics. Identifying microbial biomarkers that differentiate toxicity levels could inform personal...
maldipickr dereplicates microbial MALDI-TOF spectra to facilitate multiplexed isolation [0.03%]
MALDIPICKR通过同位素图案聚类简化基质辅助激光解吸飞行时间质谱鉴定的多重分析和混合菌株分离
Charlie Pauvert,David Wylensek,Selina Nüchtern et al.
Charlie Pauvert et al.
Motivation: Microbiologists use MALDI-TOF for fast and cheap identification of microbial isolates. However, most standard procedures rely on a commercial database. Bioinformatic tools to dereplicate MALDI-TOF spectra have...
RAM-MSA: an anytime memory-bounded method for exact multiple sequence alignment using path finding [0.03%]
基于路径搜索的精确多序列比对的任何时间内存限制方法RAM-MSA
Jue Wang,Fumihiko Ino
Jue Wang
Motivation: Multiple sequence alignment (MSA) is a crucial process in bioinformatics, essential for understanding functional or structural relationships among DNA or protein sequences. As the number of sequences increases...
Interpretable machine learning for low-sample multi-omics: a case study of ferret vaccine response [0.03%]
低样本多组学的可解释机器学习：基于FERRET疫苗反应研究的一个案例分析
Nehleh Kargarfard,Robert Dunne,Carol Lee et al.
Nehleh Kargarfard et al.
Motivation: Machine Learning approaches continue to be critical to the modelling of complex biological pathways, but many of the most-used models suffer from being uninterpretable, providing little insight into underlying...
DeepTaxa: a hybrid CNN-BERT framework for 16S rRNA taxonomic classification [0.03%]
DeepTaxa：一种用于16S rDNA分类的混合CNN-BERT框架
Rana Salah,Khlood R AbdElaal,Lobna Ghonaim et al.
Rana Salah et al.
Motivation: Accurate species-level classification of prokaryotic 16S rRNA sequences remains difficult: existing tools rely on exact alignment, k-mer heuristics, or phylogenetic placement and are limited by incomplete refe...
Improving calls of differentially transcribed enhancers and their upstream regulators [0.03%]
改进差异转录的增强子及其上游调节因子的识别方法
Hope A Townsend,Jacob T Stanley,Mary A Allen et al.
Hope A Townsend et al.
Most disease-associated variants reside in transcribed regulatory elements (tREs), whose differential transcription enables identification of upstream regulators and enhancer targets. However, their low and highly variable expression compli...