Plasma CHI3L1 as a marker of cognitive and structural brain changes in radiologically isolated syndrome [0.03%]
血浆CHI3L1作为影像学孤立综合征认知和结构性脑改变的标志物
Raphael Schneider,Koroboshka Brand-Arzamendi,Timothy Reynold Lim et al.
Raphael Schneider et al.
Background: Radiologically isolated syndrome (RIS) is characterised by incidental MRI findings suggestive of multiple sclerosis (MS) in individuals without typical MS symptoms. People with RIS (pwRIS) may have subtle mani...
Comprehensive evaluation of telehealth outpatient stroke service in rural and remote Australia: a multicentre study protocol [0.03%]
澳大利亚农村和偏远地区远程医疗门诊卒中服务综合评估：多中心研究方案
Carlos Garcia-Esperon,Luis Mena Romo,Heidi Janssen et al.
Carlos Garcia-Esperon et al.
Introduction: Without guideline-based secondary management, ~10%-20% of stroke patients suffer a recurrent event within 12 months. Access to stroke specialists in rural areas is scarce, which may limit appropriate seconda...
Bilateral thalamic involvement in scrub typhus meningoencephalitis: a case report of an uncommon neuroimaging pattern mimicking Japanese encephalitis [0.03%]
以日本脑炎为表现的恶性疟疾并红斑狼疮患者的病例报告及文献回顾
Achyoot Sharan Koirala,Ujjwal Kumar Shah,Ram Bahadur Khadka et al.
Achyoot Sharan Koirala et al.
Background: Scrub typhus is a major but under-recognised cause of acute febrile illness in Southeast Asia. Neurological involvement occurs in up to 20% of cases, but bilateral thalamic lesions, which are classically assoc...
Screening for mood disorders after stroke: feasibility of a community-based pathway [0.03%]
卒中后筛查情绪障碍：社区途径的可行性研究
Octavio Garcia Silva,Dianne Lesley Marsden,Shalini Rajan et al.
Octavio Garcia Silva et al.
Objective: To assess the prevalence of anxiety and depression 4-6 months poststroke, examine whether demographic factors were associated with response status, and evaluate feasibility outcomes, including acceptability and...
Use of complementary therapies is associated with expectations of treatment effectiveness among persons with multiple sclerosis [0.03%]
康复疗法的使用与多发性硬化患者对其治疗有效性的期望有关
Mina Stanikić,Nina Steinemann,Jesús López-Alcalde et al.
Mina Stanikić et al.
Background: Complementary therapies (CTs) are widely used among persons with multiple sclerosis (MS). Patients' expectations of treatment effectiveness are linked to CT use in the general population. However, little is kn...
Chorea-acanthocytosis masquerading as a progressive seizure disorder with apparent early immunotherapy responsiveness [0.03%]
以进行性癫痫样症状为表现的 chorea-acanthocytosis 1 例并似乎对早期免疫治疗有反应
Amarachi Nwamba,Beheshta Harghandiwal,Bryan Ceronie et al.
Amarachi Nwamba et al.
Chorea-acanthocytosis (ChAc) is a rare genetic disorder characterised by a hyperkinetic movement disorder, dystonia, cognitive and neuropsychiatric deficits and seizures. We report the case of a 30-year-old patient who presented with a deca...
Two phase 1 randomised studies investigating the safety and pharmacokinetics of bepranemab in healthy participants of different ethnicities [0.03%]
在不同种族受试者中研究贝普兰单抗的安全性和药代动力学的两项I期随机研究
Tim J Buchanan,Colin Ewen,Irene Rebollo Mesa et al.
Tim J Buchanan et al.
Background: Bepranemab is a recombinant, humanised, full-length IgG4 monoclonal antibody targeting a mid-region tau epitope. Two phase 1 studies assessed the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic...
Peripheral frataxin levels govern long-term clinical progression in Friedreich ataxia [0.03%]
外周frataxin水平决定friedreich共济失调的长期临床进展
Christian Rummey,Ian A Blair,Clementina Mesaros et al.
Christian Rummey et al.
Background: Novel therapeutics for Friedreich ataxia employ diverse strategies to increase frataxin protein levels, and a better understanding of the relation to clinical outcomes could strengthen their use as pharmacodyn...
At the extreme limits of L-DOPA therapy: probable dopamine dysregulation and psychiatric complications in Parkinson's disease [0.03%]
论左旋多巴治疗的极限：帕金森病患者多巴胺失调和精神障碍的可能性
Niko Oikarinen,Emma Ottela,Jaana Rönkä et al.
Niko Oikarinen et al.
Background: Dopamine dysregulation syndrome (DDS) is an uncommon but debilitating complication of Parkinson's disease (PD), characterised by a compulsive overuse of dopaminergic therapy. Most reported cases are male and i...
Serum drug levels and JCV assay discrepancies after switching from originator to biosimilar natalizumab [0.03%]
切换至 Natalizumab 生物类似药后血清药物浓度及 JCV 检测的分歧
Einar August Høgestøl,Åge Winje Brustad,Elisabeth Gulowsen Celius et al.
Einar August Høgestøl et al.
Background: In January 2024, all people with multiple sclerosis (pwMS) treated with natalizumab (NTZ) at Oslo University Hospital were switched from originator to biosimilar NTZ. We prospectively evaluated disease activit...