Maria Bilen,Yubing Liu,Imane Chakroun et al.
Maria Bilen et al.
Mitochondrial dysfunction and fragmentation are observed in various circumstances, such as neurodegeneration and aging. Studies have shown that altered mitochondrial function activates the integrated stress response (ISR), with ATF4 serving...
Distinct repeat architecture landscapes in the proteomes of protozoan parasites [0.03%]
原生动物寄生虫蛋白组中独特的重复结构景观
Hirotaka Matsumoto,Jing Hong
Hirotaka Matsumoto
Protozoan parasites cause major infectious diseases and pose persistent global health challenges, particularly the emergence of drug-resistant strains. Tandem repeats and other repetitive architectures are widespread in proteomes and have b...
Long non-coding RNA triplex-dependent regulation of melanoma gene networks [0.03%]
与黑色素瘤基因网络相关的长链非编码RNA三链依赖性调节
Kushani Shah,Eleni Anastasakou,Leinal Sejour et al.
Kushani Shah et al.
SLNCR is a long non-coding RNA (lncRNA) that promotes melanoma formation. Previously, we have shown that SLNCR regulates gene expression via its interactions with different transcription factors. Here we show that SLNCR is associated with s...
Amy Z M Stephen,Arian Raje,Heather H Sestili et al.
Amy Z M Stephen et al.
Differences in enhancer activity between species can help drive phenotypic diversity, yet enhancers often have conserved functions despite rapid sequence evolution, posing a challenge for quantifying their functional differences between spe...
Power-law penalties correct distance bias in single-cell co-accessibility and deep-learning chromatin interaction predictions [0.03%]
幂律惩罚可校正单细胞共访问和染色质相互作用深度学习预测中的距离偏置
Luca Schlegel,Fabio Gómez Cano,Alexandre P Marand et al.
Luca Schlegel et al.
Scalable proxies for 3D genome contacts-such as single-cell co-accessibility and deep learning predictions-have emerged as powerful alternatives to chromatin capture-based methods, but predictions systematically overestimate long-range inte...
Dimitri Desvillechabrol,Rania Ouazahrou,Juliana Pipoli da Fonseca et al.
Dimitri Desvillechabrol et al.
Genome assembly from long-read sequencing data has become a standard approach for resolving complex genomic regions and producing high-contiguity assemblies. However, the diversity of available assemblers, their varying performance across s...
Correction to 'Genome sequence assembly and annotation of MATA and MATB strains of Yarrowia lipolytica' [0.03%]
对“MATA和MATB菌株的Yarrowia lipolytica基因组序列组装与注释”的勘误
[This corrects the article DOI: 10.1093/nargab/lqaf175.]. © The Author(s) 2026. Published by Oxford University Press.
Published Erratum
NAR genomics and bioinformatics. 2026 Jun 22;8(2):lqag064. DOI:10.1093/nargab/lqag064 2026
Comprehensive mapping of identical sequences across human proteins emphasizes the widespread issue of shared epitopes in self-antigens [0.03%]
人类蛋白质中相同序列的全面映射强调了自身抗原中共有表位的普遍性问题
Guillaume Kellermann,Olivier Croce,Baharia Mograbi et al.
Guillaume Kellermann et al.
Shared epitopes pose safety and efficacy issues for T-cell immunotherapy. To characterize the extent of this problem, we performed a computational analysis establishing a complete atlas of shared identical sequences across the human and mur...
PolyGenie: a reproducible Nextflow pipeline for phenome-wide association studies using polygenic risk scores [0.03%]
基于多基因风险评分的表型全关联研究的可重复Nextflow管线PolyGenie
Xavier Farré,Mireia Gasco,Natalia Blay et al.
Xavier Farré et al.
Phenome-wide association studies (PheWAS) using polygenic risk scores (PRS) offer a powerful framework for exploring the shared genetic architecture of complex traits across diverse phenotypic domains. However, no standardized, portable pip...
Exploring molecular signatures of senescence with marker, an R Toolkit for evaluating gene sets as phenotypic markers [0.03%]
Marker：一种用于评估基因集作为表型标志的R工具包——利用分子标志探索衰老现象
Rita Martins-Silva,Alexandre Kaizeler,Nuno L Barbosa-Morais
Rita Martins-Silva
Many biological processes, including cellular senescence, manifest as diverse phenotypes across cell types and conditions. Lacking definitive markers, researchers often rely on the expression of sets of genes to identify these complex state...