RdRpCATCH: a unified resource for RNA virus discovery using viral RNA-dependent RNA polymerase profile Hidden Markov models [0.03%]
基于依赖RNA的RNA聚合酶谱系隐马尔可夫模型的RNA病毒发现统一资源(RdRpCATCH)
Dimitris Karapliafis,Uri Neri,Ingrida Olendraite et al.
Dimitris Karapliafis et al.
Recent advances in large-scale sequence mining have expanded our knowledge of RNA virus diversity. Most genome mining approaches for detecting RNA viruses rely on identifying the conserved RNA-dependent RNA polymerase (RdRp) by scanning seq...
A multiperspective evaluation framework of spatial transcriptomics clustering methods [0.03%]
空间转录组学聚类方法的多视角评估框架
Gospel Ozioma Nnadi,Vincenzo Bonnici,Simone Avesani et al.
Gospel Ozioma Nnadi et al.
Spatial transcriptomics (ST) allows the exploration of gene expression within tissue microenvironments, driving the development of multiple computational approaches for spatial domain identification. Evaluating these methods typically relie...
QutRNA2: robust tRNA modification discovery from Nanopore direct tRNA sequencing [0.03%]
QutRNA2：从纳米孔tRNA直接测序中稳健地发现tRNA修饰
Michael Piechotta,Wei Guo,Isabel S Naarmann-de Vries et al.
Michael Piechotta et al.
Transfer RNAs (tRNAs) are essential for protein synthesis and are extensively modified to ensure their structure and function. Direct RNA sequencing with Oxford Nanopore Technologies enables positional modification analysis but is challenge...
Correction to 'SyMetrics: an integrated machine learning model for evaluating the pathogenicity of synonymous variants in the human genome' [0.03%]
关于“SyMetrics：一种综合机器学习模型，用于评估人类基因组同义变异致病性的文章”的更正
[This corrects the article DOI: 10.1093/nargab/lqaf211.]. © The Author(s) 2026. Published by Oxford University Press.
Published Erratum
NAR genomics and bioinformatics. 2026 Jul 3;8(3):lqag077. DOI:10.1093/nargab/lqag077 2026
asms: finding allele-specific methylation in human genomes without phasing [0.03%]
ASMS：无需相位查找人类基因组中的等位特异性甲基化
Emanuele Raineri,Miguel Ángel Esteve Marco,Eloi Casals et al.
Emanuele Raineri et al.
Allele-specific methylation (ASM) refers to the differential DNA methylation between two alleles at a specific locus. This phenomenon can be driven by genomic imprinting (where gene expression depends on the parent of origin) or by genetic ...
An epigenetic clock for chronological age estimation in East Asian populations [0.03%]
东亚人群的表观遗传学时钟用于估算实际年龄
Kuan Chen Lu,Po-Hsiu Kuo,Amrita Chattopadhyay et al.
Kuan Chen Lu et al.
Population aging is increasing the burden of age-related disease, highlighting the need for accurate molecular tools to estimate aging. DNA methylation, a heritable epigenetic mark linked to development and age-related disease, can capture ...
Maria Bilen,Yubing Liu,Imane Chakroun et al.
Maria Bilen et al.
Mitochondrial dysfunction and fragmentation are observed in various circumstances, such as neurodegeneration and aging. Studies have shown that altered mitochondrial function activates the integrated stress response (ISR), with ATF4 serving...
Distinct repeat architecture landscapes in the proteomes of protozoan parasites [0.03%]
原生动物寄生虫蛋白组中独特的重复结构景观
Hirotaka Matsumoto,Jing Hong
Hirotaka Matsumoto
Protozoan parasites cause major infectious diseases and pose persistent global health challenges, particularly the emergence of drug-resistant strains. Tandem repeats and other repetitive architectures are widespread in proteomes and have b...
Long non-coding RNA triplex-dependent regulation of melanoma gene networks [0.03%]
与黑色素瘤基因网络相关的长链非编码RNA三链依赖性调节
Kushani Shah,Eleni Anastasakou,Leinal Sejour et al.
Kushani Shah et al.
SLNCR is a long non-coding RNA (lncRNA) that promotes melanoma formation. Previously, we have shown that SLNCR regulates gene expression via its interactions with different transcription factors. Here we show that SLNCR is associated with s...
Amy Z M Stephen,Arian Raje,Heather H Sestili et al.
Amy Z M Stephen et al.
Differences in enhancer activity between species can help drive phenotypic diversity, yet enhancers often have conserved functions despite rapid sequence evolution, posing a challenge for quantifying their functional differences between spe...