Characterizing highly conserved fragments in 3'UTRs via statistical and transfer learning approaches [0.03%]
基于统计和迁移学习方法的3'UTR高保守片段特征研究
Eric S Ho,Ash Baeck-Hubloux,Nathan Dinh et al.
Eric S Ho et al.
3' Untranslated regions (3'UTRs) serve as regulatory platforms that modulate steps in the central dogma through the binding of RNA-binding proteins and miRNAs. Their binding sites are often identified through orthologous regions among speci...
A theoretical and experimental framework enables low-coverage sequencing for accurate quantification of genome-wide cytosine modification levels [0.03%]
一种理论和实验框架使低覆盖率测序能够准确量化全基因组胞嘧啶修饰水平成为可能
Christian E Loo,Johanna M Fowler,Heqiao Zhu et al.
Christian E Loo et al.
5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) regulate gene expression and exhibit dynamic levels during development and disease. While high-depth, base-resolution studies offer the most detailed view of epigenetic landscapes, m...
bMINTY: enabling reproducible management of high-throughput sequencing analysis results and their metadata [0.03%]
bMINTY：启用高通量测序分析结果及其元数据的可重复管理
Konstantinos Kapelios,Haris Manousaki,Vasiliki Kotsira et al.
Konstantinos Kapelios et al.
Due to the large scale of high-throughput sequencing data generation, the community has established standards that promote Findable, Accessible, Interoperable and Reusable (FAIR) science. However, critical obstacles remain since best practi...
Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience in Drosophila neuromodulatory neurons [0.03%]
单细胞分辨率的RNA测序揭示了果蝇神经调节神经元中交配体验的分子标志物
Julia Ryvkin,Anat Shmueli,Ayalla Aharony et al.
Julia Ryvkin et al.
Flexible behavioral responses depend on the ability of neural circuits to adapt their physiology and output to changing social and environmental contexts. Neuromodulation is central to this flexibility, yet how specific experiences are enco...
metaWEPP: leveraging biobank-scale intra-species phylogenies for near-haplotype resolution in metagenomic analysis [0.03%]
利用大规模生物库的种内系统发育树进行宏基因组分析的近乎单倍型分辨率研究-metaWEPP工具箱
Pranav Gangwar,Qiwen Xu,Jaden Seangmany et al.
Pranav Gangwar et al.
Metagenomic sequencing is transforming diverse areas of health and biological sciences, including pathogen surveillance, clinical diagnostics, and microbiome research. However, the inherent complexity of metagenomic data limits most computa...
Correction to 'Challenges in predicting chromatin accessibility differences between species' [0.03%]
对“预测染色质可及性差异的挑战”的修正
[This corrects the article DOI: 10.1093/nargab/lqag059.]. © The Author(s) 2026. Published by Oxford University Press.
Published Erratum
NAR genomics and bioinformatics. 2026 Jul 21;8(3):lqag083. DOI:10.1093/nargab/lqag083 2026
The challenges of single cell transcriptomics on difficult human tissue: the placenta [0.03%]
单细胞转录组在棘手的人体组织中的挑战：胎盘研究案例
Theodoros Xenakis,George T Hall,Jose J Moreno-Villena et al.
Theodoros Xenakis et al.
Demand for the application of single cell transcriptomics on difficult tissues, processed and stored in disparate conditions, has led to the development of various single cell modalities. We focus on the placenta, a challenging tissue to tr...
Sarand: exploring antimicrobial resistance gene neighbourhoods in complex metagenomic assembly graphs [0.03%]
Sarand：在复杂宏基因组装配图中探索抗菌药物抗性基因邻域
Somayeh Kafaie,Shahlla Naseri,David B J Mahoney et al.
Somayeh Kafaie et al.
Antimicrobial resistance (AMR) is a major global challenge to human and animal health. The genomic element (e.g. chromosome, plasmid, and genomic islands) and neighbouring genes associated with an AMR gene play a major role in its function,...
ProteoMeter: a pipeline for integrating multi-PTM and limited proteolysis data to reveal modification-structure coupling at the residue level [0.03%]
基于多磷酸化位点及有限蛋白酶解的蛋白质修饰结构解析方法Protetometer：揭示修饰与结构关联性
Jordan C Rozum,Amy C Sims,Xiaolu Li et al.
Jordan C Rozum et al.
Systemic perturbations trigger extensive changes across the proteome-altering protein abundance, post-translational modifications (PTMs), conformational states, and complex assembly. Interpreting these effects demands computational pipeline...
A systematic benchmark of bioinformatics methods for single-cell and spatial RNA-seq nanopore long reads data [0.03%]
单细胞和空间rna测序纳米孔长读数据的生物信息学方法系统基准测试
Ali Hamraoui,Audrey Onfroy,Catherine Sénamaud-Beaufort et al.
Ali Hamraoui et al.
Alternative splicing plays a crucial role in transcriptomic complexity, yet remains difficult to resolve at the single-cell level due to the limitations of short-read technologies. Coupling single-cell with long-read sequencing offers full-...